Low-n oligomers as therapeutic targets of Alzheimer’s disease

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

REVIEW: Curcumin and Alzheimer's Disease

(2010) Tsuyoshi Hamaguchi et al.   CNS Neuroscience & Therapeutics

Effects of the English (H6R) and Tottori (D7N) Familial Alzheimer Disease Mutations on Amyloid β-Protein Assembly and Toxicity

(2010) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mouse Model of Amyloid   Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

(2010) T. Tomiyama et al.   JOURNAL OF NEUROSCIENCE

Why Pleiotropic Interventions are Needed for Alzheimer's Disease

(2010) Sally A. Frautschy et al.   MOLECULAR NEUROBIOLOGY

Aβ oligomers inhibit synapse remodelling necessary for memory consolidation

(2010) Darragh B. Freir et al.   NEUROBIOLOGY OF AGING

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

(2009) Tsuyoshi Hamaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

A Specific Enzyme-Linked Immunosorbent Assay for Measuring β-Amyloid Protein Oligomers in Human Plasma and Brain Tissue of Patients With Alzheimer Disease

(2009) Weiming Xia et al.   ARCHIVES OF NEUROLOGY

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble amyloid-  peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo

(2008) N.-W. Hu et al.   BRAIN

Amyloid β -Protein Assembly as a Therapeutic Target of Alzheimers Disease

(2008) Ghiam Yamin et al.   CURRENT PHARMACEUTICAL DESIGN

Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity

(2008) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Grape-Derived Polyphenolics Prevent A  Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

(2008) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON