Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature

(2013) Farzaneh Salem et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Using human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans

(2013) Christopher R. Gibson et al.   XENOBIOTICA

Cytochrome P450 variations in different ethnic populations

(2012) Joseph McGraw et al.   Expert Opinion on Drug Metabolism & Toxicology

Quantitative High-Throughput Screening for Chemical Toxicity in a Population-Based In Vitro Model

(2012) Eric F. Lock et al.   TOXICOLOGICAL SCIENCES

Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors

(2011) H. K. Crewe et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

(2011) Richard S. Judson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Clinically Relevant Genetic Variations in Drug Metabolizing Enzymes

(2011) Navin Pinto et al.   CURRENT DRUG METABOLISM

Novel advances in cytochrome P450 research

(2011) Deepika Singh et al.   DRUG DISCOVERY TODAY

In Vitro Assessment of the Allelic Variants of Cytochrome P450

(2011) Masahiro Hiratsuka   Drug Metabolism and Pharmacokinetics

Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors

(2011) Ruili Huang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

(2011) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

(2011) Thomas B. Knudsen et al.   TOXICOLOGY

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

(2010) Matthew T. Martin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cytochrome P450-mediated metabolism in the human gut wall

(2010) Kirstin Thelen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Advancing Exposure Characterization for Chemical Evaluation and Risk Assessment

(2010) Elaine A. Cohen Hubal et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Biokinetic Modeling andin Vitro–in VivoExtrapolations

(2010) Bas J. Blaauboer   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

(2010) Daniel M. Rotroff et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

(2010) David Hallifax et al.   PHARMACEUTICAL RESEARCH

Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

(2010) Daniel M. Rotroff et al.   TOXICOLOGICAL SCIENCES

Human hepatic CYP2B6 developmental expression: The impact of age and genotype

(2009) Edward L. Croom et al.   BIOCHEMICAL PHARMACOLOGY

Evaluation of Recombinant Cytochrome P450 Enzymes as an in Vitro System for Metabolic Clearance Predictions

(2009) R. A. Stringer et al.   DRUG METABOLISM AND DISPOSITION

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast™ chemicals

(2009) Andrew W. Knight et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Metabolism, variability and risk assessment

(2009) J.L.C.M. Dorne   TOXICOLOGY

Reaction Phenotyping: Current Industry Efforts to Identify Enzymes Responsible for Metabolizing Drug Candidates

(2008) Timothy W. Harper et al.   AAPS Journal

Pharmacokinetics and Bioequivalence Study of Two Tablet Formulations of Lovastatin in Healthy Volunteers

(2008) Fiorenzo Mignini et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

In vitro measurements of metabolism for application in pharmacokinetic modeling

(2008) John C. Lipscomb et al.   PHARMACOLOGY & THERAPEUTICS

Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment

(2008) Robert J. Kavlock et al.   RISK ANALYSIS

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE

Toxicity Testing in the 21st Century: Bringing the Vision to Life

(2008) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES