­­LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation

Ubiquitination of the Transcription Factor IRF-3 Activates RIPA, the Apoptotic Pathway that Protects Mice from Viral Pathogenesis

(2016) Saurabh Chattopadhyay et al.   IMMUNITY

dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

(2015) Amanda M. Nelson et al.   Cell Stem Cell

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

(2015) Bertrand Boisson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional IRF3 deficiency in a patient with herpes simplex encephalitis

(2015) Line Lykke Andersen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recurrent turnover of senescent cells during regeneration of a complex structure

(2015) Maximina H Yun et al.   eLife

Cellular Inhibitor of Apoptosis Protein cIAP2 Protects against Pulmonary Tissue Necrosis during Influenza Virus Infection to Promote Host Survival

(2014) Ian Gaël Rodrigue-Gervais et al.   Cell Host & Microbe

Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice

(2014) Y. H. C. Leung et al.   JOURNAL OF GENERAL VIROLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death

(2014) Nieves Peltzer et al.   Cell Reports

Myosin VIII associates with microtubule ends and together with actin plays a role in guiding plant cell division

(2014) Shu-Zon Wu et al.   eLife

Polyglucosan body myopathy caused by defective ubiquitin ligase RBCK1

(2013) Johanna Nilsson et al.   ANNALS OF NEUROLOGY

IL-24 sensitizes tumor cells to TLR3-mediated apoptosis

(2013) R Weiss et al.   CELL DEATH AND DIFFERENTIATION

TLR3 immunity to infection in mice and humans

(2013) Shen-Ying Zhang et al.   CURRENT OPINION IN IMMUNOLOGY

Toll-like receptor 3 in viral pathogenesis: friend or foe?

(2013) Renzo Perales-Linares et al.   IMMUNOLOGY

Whole-genome DNA/RNA sequencing identifies truncating mutations in RBCK1 in a novel Mendelian disease with neuromuscular and cardiac involvement

(2013) Kai Wang et al.   Genome Medicine

Generation and physiological roles of linear ubiquitin chains

(2012) Henning Walczak et al.   BMC BIOLOGY

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

(2012) Y Estornes et al.   CELL DEATH AND DIFFERENTIATION

HeterozygousTBK1mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

(2012) Melina Herman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

(2012) Bertrand Boisson et al.   NATURE IMMUNOLOGY

Ultraviolet radiation damages self noncoding RNA and is detected by TLR3

(2012) Jamie J Bernard et al.   NATURE MEDICINE

Toll-like receptor 3 gene polymorphisms and severity of pandemic A/H1N1/2009 influenza in otherwise healthy children

(2012) Susanna Esposito et al.   Virology Journal

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

(2011) Vanessa Sancho-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

(2011) Kyung-Soo Inn et al.   MOLECULAR CELL

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis

(2010) Rebeca Pérez de Diego et al.   IMMUNITY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

(2009) Yuping Lai et al.   NATURE MEDICINE

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

(2008) Karen A. Cavassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice

(2008) Ulrike Lichti et al.   Nature Protocols