Solution conformations of Zika NS2B-NS3pro and its inhibition by natural products from edible plants

A human antibody against Zika virus crosslinks the E protein to prevent infection

(2017) S. Saif Hasan et al.   Nature Communications

Inhibitory effect of flavonoids against NS2B-NS3 protease of ZIKA virus and their structure activity relationship

(2016) Hee-jung Lim et al.   BIOTECHNOLOGY LETTERS

Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody

(2016) Lianpan Dai et al.   Cell Host & Microbe

Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease

(2016) Xia Chen et al.   CELL RESEARCH

Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice

(2016) Cui Li et al.   Cell Stem Cell

The Role of Protein Loops and Linkers in Conformational Dynamics and Allostery

(2016) Elena Papaleo et al.   CHEMICAL REVIEWS

Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease

(2016) Jasper F.W. Chan et al.   JOURNAL OF INFECTION

Zika virus: An update on epidemiology, pathology, molecular biology, and animal model

(2016) Suzane Ramos da Silva et al.   JOURNAL OF MEDICAL VIROLOGY

Potential for Zika virus introduction and transmission in resource-limited countries in Africa and the Asia-Pacific region: a modelling study

(2016) Isaac I Bogoch et al.   LANCET INFECTIOUS DISEASES

Zika virus: history of a newly emerging arbovirus

(2016) Nitwara Wikan et al.   LANCET INFECTIOUS DISEASES

Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

(2016) Gopal Sapparapu et al.   NATURE

Conformational footprints

(2016) Buyong Ma et al.   Nature Chemical Biology

Zika Virus Associated with Microcephaly

(2016) Jernej Mlakar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence of Sexual Transmission of Zika Virus

(2016) Eric D’Ortenzio et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

(2016) Jian Lei et al.   SCIENCE

Experts fear Zika's effects may be even worse than thought

(2016) G. Vogel   SCIENCE

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43

(2016) Liangzhong Lim et al.   PLOS BIOLOGY

Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons

(2016) Jasper Fuk-Woo Chan et al.   EBioMedicine

The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development

(2015) Dahai Luo et al.   ANTIVIRAL RESEARCH

Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: Inhibition kinetics and docking studies

(2015) Lorena Ramos Freitas de Sousa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Flavonoid Intake in European Adults (18 to 64 Years)

(2015) Anna Vogiatzoglou et al.   PLoS One

NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics

(2015) Garvita Gupta et al.   PLoS One

Dynamic Principle for Designing Antagonistic/Agonistic Molecules for EphA4 Receptor, the Only Known ALS Modifier

(2014) Haina Qin et al.   ACS Chemical Biology

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI

(2014) Wan-Na Chen et al.   FEBS LETTERS

The intrinsic disorder status of the human hepatitis C virus proteome

(2014) Xiao Fan et al.   Molecular BioSystems

Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus

(2013) Muslum Yildiz et al.   ACS Chemical Biology

NMR Analysis of a Novel Enzymatically Active Unlinked Dengue NS2B-NS3 Protease Complex

(2013) Young Mee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural biology of dengue virus enzymes: Towards rational design of therapeutics

(2012) Christian G. Noble et al.   ANTIVIRAL RESEARCH

Intrinsically Unstructured Domain 3 of Hepatitis C Virus NS5A Forms a “Fuzzy Complex” with VAPB-MSP Domain Which Carries ALS-Causing Mutations

(2012) Garvita Gupta et al.   PLoS One

Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation

(2011) C. G. Noble et al.   JOURNAL OF VIROLOGY

Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma

(2011) Reason Wilken et al.   Molecular Cancer

Dynamically-Driven Inactivation of the Catalytic Machinery of the SARS 3C-Like Protease by the N214A Mutation on the Extra Domain

(2011) Jiahai Shi et al.   PLoS Computational Biology

Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding Promiscuity

(2009) Haina Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

A comparative biochemical analysis of the NS2B(H)–NS3pro protease complex from four dengue virus serotypes

(2008) T IEMPRIDEE et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Docking of Noncompetitive Inhibitors into Dengue Virus Type 2 Protease: Understanding the Interactions with Allosteric Binding Sites

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