NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics

Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations

(2015) Liangzhong Lim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Binding mode of the activity-modulating C-terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease

(2014) Laura de la Cruz et al.   FEBS Journal

The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI

(2014) Wan-Na Chen et al.   FEBS LETTERS

TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA

(2014) Haina Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus

(2013) Muslum Yildiz et al.   ACS Chemical Biology

A small compound targeting the interaction between nonstructural proteins 2B and 3 inhibits dengue virus replication

(2013) Sabar Pambudi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NMR Analysis of a Novel Enzymatically Active Unlinked Dengue NS2B-NS3 Protease Complex

(2013) Young Mee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

New Binding Site Conformations of the Dengue Virus NS3 Protease Accessed by Molecular Dynamics Simulation

(2013) Hugo de Almeida et al.   PLoS One

Structural biology of dengue virus enzymes: Towards rational design of therapeutics

(2012) Christian G. Noble et al.   ANTIVIRAL RESEARCH

Determination of Secondary Structure Populations in Disordered States of Proteins Using Nuclear Magnetic Resonance Chemical Shifts

(2012) Carlo Camilloni et al.   BIOCHEMISTRY

Early Dengue Virus Protein Synthesis Induces Extensive Rearrangement of the Endoplasmic Reticulum Independent of the UPR and SREBP-2 Pathway

(2012) José Peña et al.   PLoS One

Intrinsically Unstructured Domain 3 of Hepatitis C Virus NS5A Forms a “Fuzzy Complex” with VAPB-MSP Domain Which Carries ALS-Causing Mutations

(2012) Garvita Gupta et al.   PLoS One

Binding of Low Molecular Weight Inhibitors Promotes Large Conformational Changes in the Dengue Virus NS2B-NS3 Protease: Fold Analysis by Pseudocontact Shifts

(2011) Laura de la Cruz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation

(2011) C. G. Noble et al.   JOURNAL OF VIROLOGY

New Merck and Vertex drugs raise standard of care in hepatitis C

(2011) Cormac Sheridan   NATURE BIOTECHNOLOGY

Organelle-Like Membrane Compartmentalization of Positive-Strand RNA Virus Replication Factories

(2010) Johan A. den Boon et al.   Annual Review of Microbiology

Novel Dengue Virus-Specific NS2B/NS3 Protease Inhibitor, BP2109, Discovered by a High-Throughput Screening Assay

(2010) Chi-Chen Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Elimination of the Native Structure and Solubility of the hVAPB MSP Domain by the Pro56Ser Mutation That Causes Amyotrophic Lateral Sclerosis

(2010) Jiahai Shi et al.   BIOCHEMISTRY

Dengue: a continuing global threat

(2010) Maria G. Guzman et al.   NATURE REVIEWS MICROBIOLOGY

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

(2010) N. S. Heaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Best Practices in Dengue Surveillance: A Report from the Asia-Pacific and Americas Dengue Prevention Boards

(2010) Mark E. Beatty et al.   PLoS Neglected Tropical Diseases

A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum

(2009) Elisa Fasana et al.   FASEB JOURNAL

Insight into “insoluble proteins” with pure water

(2009) Jianxing Song   FEBS LETTERS

Quantifying Correlations Between Allosteric Sites in Thermodynamic Ensembles

(2009) Christopher L. McClendon et al.   Journal of Chemical Theory and Computation

NMR Evidence for Forming Highly Populated Helical Conformations in the Partially Folded hNck2 SH3 Domain

(2008) Jingxian Liu et al.   BIOPHYSICAL JOURNAL

Structural proteomics of dengue virus

(2008) Rushika Perera et al.   CURRENT OPINION IN MICROBIOLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Mechanism of NS2B-Mediated Activation of NS3pro in Dengue Virus: Molecular Dynamics Simulations and Bioassays

(2008) Z. Zuo et al.   JOURNAL OF VIROLOGY

Modification of intracellular membrane structures for virus replication

(2008) Sven Miller et al.   NATURE REVIEWS MICROBIOLOGY

HIV-1 protease folding and the design of drugs which do not create resistance

(2007) RA Broglia et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY