Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

(2015) Sara Martire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair

(2015) Rajendra Prasad et al.   PLoS One

Sex differences in mitochondrial biogenesis determine neuronal death and survival in response to oxygen glucose deprivation and reoxygenation

(2014) Jaswinder Sharma et al.   BMC NEUROSCIENCE

DNA breaks and chromosomal aberrations arise when replication meets base excision repair

(2014) Michael Ensminger et al.   JOURNAL OF CELL BIOLOGY

New Insights into PARP Inhibitors' Effect on Cell Cycle and Homology-Directed DNA Damage Repair

(2014) P. Jelinic et al.   MOLECULAR CANCER THERAPEUTICS

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function

(2014) Bartosz Szczesny et al.   NUCLEIC ACIDS RESEARCH

Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair

(2014) Rajendra Prasad et al.   NUCLEIC ACIDS RESEARCH

Replicative Bypass of Abasic Site in Escherichia coli and Human Cells: Similarities and Differences

(2014) Savithri Weerasooriya et al.   PLoS One

Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis

(2014) Z. D. Nagel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

(2014) S. A. Andrabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD + Depletion

(2014) Elise Fouquerel et al.   Cell Reports

TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death

(2013) Justyna Sosna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Computational classification of mitochondrial shapes reflects stress and redox state

(2013) T Ahmad et al.   Cell Death & Disease

Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

(2013) Jennifer A. Calvo et al.   PLoS Genetics

N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress

(2012) Josie J. Gray et al.   BRAIN RESEARCH

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

PARPs and the DNA damage response

(2012) F. G. Sousa et al.   CARCINOGENESIS

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models

(2012) P Vandenabeele et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage

(2012) Yusuke Kageyama et al.   JOURNAL OF CELL BIOLOGY

Intracellular calcium plays a critical role in the alcohol-mediated death of cerebellar granule neurons

(2012) Dimitrios E. Kouzoukas et al.   JOURNAL OF NEUROCHEMISTRY

Increased PARP-1 Association with DNA in Alkylation Damaged, PARP-Inhibited Mouse Fibroblasts

(2012) P. S. Kedar et al.   MOLECULAR CANCER RESEARCH

Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease

(2012) Joanna B. Strosznajder et al.   MOLECULAR NEUROBIOLOGY

A Dual Role for Poly(ADP-Ribose) Polymerase-1 
During Caspase-Dependent Apoptosis

(2012) Fengjiao Zhang et al.   TOXICOLOGICAL SCIENCES

Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress

(2011) X Liu et al.   CELL DEATH AND DIFFERENTIATION

BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation

(2011) L Cabon et al.   CELL DEATH AND DIFFERENTIATION

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

The role of PARP activation in glutamate-induced necroptosis in HT-22 cells

(2010) Xingshun Xu et al.   BRAIN RESEARCH

Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death

(2010) C. Blenn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks

(2010) Michelle L. Heacock et al.   DNA REPAIR

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

(2010) Cédric Artus et al.   EMBO JOURNAL

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of the Mitochondrion in Programmed Necrosis

(2010) Christopher P. Baines   Frontiers in Physiology

Mitochondrial Localization of PARP-1 Requires Interaction with Mitofilin and Is Involved in the Maintenance of Mitochondrial DNA Integrity

(2009) Marianna N. Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)

(2009) Yingfei Wang et al.   JOURNAL OF NEUROCHEMISTRY

Intra-mitochondrial poly(ADP-ribosyl)ation: Potential role for alpha-ketoglutarate dehydrogenase

(2009) Eszter Pankotai et al.   MITOCHONDRION

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

(2008) Andrey Y. Abramov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Imaging individual mRNA molecules using multiple singly labeled probes

(2008) Arjun Raj et al.   NATURE METHODS

Mutational specificity and genetic control of replicative bypass of an abasic site in yeast

(2008) V. Pages et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA