σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain

Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism

(2014) Veronica Francardo et al.   BRAIN

The Concise Guide to PHARMACOLOGY 2013/14: Ligand-Gated Ion Channels

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sigma-1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of mechanical allodynia in mice and neuropathic rats

(2013) Ji-Young Moon et al.   EXPERIMENTAL NEUROLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Spinal Astrocytic Activation Contributes to Mechanical Allodynia in a Rat Chemotherapy-Induced Neuropathic Pain Model

(2013) Xi-Tuan Ji et al.   PLoS One

Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice

(2012) Francisco Rafael Nieto et al.   JOURNAL OF PAIN

Evidence That Spinal Astrocytes but Not Microglia Contribute to the Pathogenesis of Paclitaxel-Induced Painful Neuropathy

(2012) Haijun Zhang et al.   JOURNAL OF PAIN

Contribution of Microglia and Astrocytes to the Central Sensitization, Inflammatory and Neuropathic Pain in the Juvenile Rat

(2012) Hiroshi Ikeda et al.   Molecular Pain

Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice

(2012) Renzo Mancuso et al.   Neurotherapeutics

A Functional Relationship Between Trigeminal Astroglial Activation and NR1 Expression in a Rat Model of Temporomandibular Joint Inflammation

(2012) Shuxing Wang et al.   PAIN MEDICINE

A practical guide to evaluating colocalization in biological microscopy

(2011) Kenneth W. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke

(2011) Karsten Ruscher et al.   BRAIN

Chemical stimulation of the ST36 acupoint reduces both formalin-induced nociceptive behaviors and spinal astrocyte activation via spinal alpha-2 adrenoceptors

(2011) Suk-Yun Kang et al.   BRAIN RESEARCH BULLETIN

Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation

(2011) Dae-Hyun Roh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Brain-derived neurotrophic factor–activated astrocytes produce mechanical allodynia in neuropathic pain

(2011) X. Zhang et al.   NEUROSCIENCE

Spinal Astrocytic Activation Is Involved in a Virally-Induced Rat Model of Neuropathic Pain

(2011) Gui-He Zhang et al.   PLoS One

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1

(2010) Yong-Jing Gao et al.   GLIA

Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia

(2010) Yong-Jing Gao et al.   JOURNAL OF NEUROCHEMISTRY

A p38 Mitogen-Activated Protein Kinase-Dependent Mechanism of Disinhibition in Spinal Synaptic Transmission Induced by Tumor Necrosis Factor- 

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Activation of the neurokinin-1 receptor in rat spinal astrocytes induces Ca2+ release from IP3-sensitive Ca2+ stores and extracellular Ca2+ influx through TRPC3

(2010) Kanako Miyano et al.   NEUROCHEMISTRY INTERNATIONAL

Is astrocyte calcium signaling relevant for synaptic plasticity?

(2010) Sarrah Ben Achour et al.   Neuron Glia Biology

The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study

(2010) T.A. Mavlyutov et al.   NEUROSCIENCE

Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCα and ɛ, but not the PKCζ, isoforms

(2010) Dae-Hyun Roh et al.   NEUROSCIENCE LETTERS

Glial Cells and Chronic Pain

(2010) Romain-Daniel Gosselin et al.   NEUROSCIENTIST

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

(2010) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Substance P1–7 induces antihyperalgesia in diabetic mice through a mechanism involving the naloxone-sensitive sigma receptors

(2009) Anna Carlsson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

(2009) Y.-J. Gao et al.   JOURNAL OF NEUROSCIENCE

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury

(2009) Beatriz de la Puente et al.   PAIN

When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor

(2009) T.-P. Su et al.   Science Signaling

Intrathecal Injection of the ς1 Receptor Antagonist BD1047 Blocks Both Mechanical Allodynia and Increases in Spinal NR1 Expression during the Induction Phase of Rodent Neuropathic Pain

(2008) Dae-Hyun Roh et al.   ANESTHESIOLOGY

Activation of p38 Mitogen-activated Protein Kinase in Spinal Microglia Contributes to Incision-induced Mechanical Allodynia

(2008) Yeong-Ray Wen et al.   ANESTHESIOLOGY

Depletion of capsaicin sensitive afferents prevents lamina-dependent increases in spinal N-methyl-d-aspartate receptor subunit 1 expression and phosphorylation associated with thermal hyperalgesia in neuropathic rats

(2008) Dae-Hyun Roh et al.   EUROPEAN JOURNAL OF PAIN

Intrathecal administration of sigma-1 receptor agonists facilitates nociception: Involvement of a protein kinase C-dependent pathway

(2008) Dae-Hyun Roh et al.   JOURNAL OF NEUROSCIENCE RESEARCH

What Is the Role of Astrocyte Calcium in Neurophysiology?

(2008) Cendra Agulhon et al.   NEURON

Interleukin 1β facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation

(2008) R.-X. Zhang et al.   NEUROSCIENCE

Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury

(2008) R. Terayama et al.   NEUROSCIENCE

IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats

(2007) Rui-Xin Zhang et al.   PAIN