Article
Ophthalmology
Fabian A. Braeu, Thanadet Chuangsuwanich, Tin A. Tun, Shamira Perera, Rahat Husain, Alexandre H. Thiery, Tin Aung, George Barbastathis, Michael J. A. Girard
Summary: Using artificial intelligence techniques, the study aims to assess the robustness of the optic nerve head (ONH) by analyzing biomechanical knowledge through optical coherence tomography (OCT). Three AI algorithms were compared to predict ONH robustness and the DGCNN algorithm outperformed the others. The study suggests that ONH robustness can be assessed from a single OCT scan, providing potential insights into identifying fast visual field loss progressors.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Lei Guo, Jun Tao, Yang Tong, Shichao Chen, Xin Zhao, Rui Hua
Summary: This study investigated the morphological and vascular characteristics of the optic nerve head (ONH) in normal guinea pigs using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). The results showed significant differences in refractive error, intraocular pressure (IOP), and circumpapillary retinal nerve fibre layer (cpRNFL) thickness between the 3-week and 4-week groups. There were no significant differences in vascular characteristics between the two groups, but a positive correlation was found between total vessel length and cpRNFL thickness, and a negative correlation was found between total vessel length and IOP.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Nathaniel Pappenhagen, Eric Yin, Autumn B. Morgan, Charles C. Kiehlbauch, Denise M. Inman
Summary: This study investigated the metabolic changes in optic nerve head astrocytes and found significant differences in glycolytic and respiratory activity between stretched and control cells. Stretched optic nerve head astrocytes showed increased dependency on glutamine, suggesting the need for NAD + replenishment for sustained glycolysis and provision of carbon for TCA cycle intermediates.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Ophthalmology
Golnoush Mahmoudinezhad, Mark Lin, Alessandro Rabiolo, Esteban Morales, Pradtana Hirunpatravong, Farideh Sharifipour, Joseph Caprioli
Summary: The presence of an acquired pit of the optic nerve in patients with primary open-angle glaucoma is associated with fast rates of visual field decay. Identifying patients with this condition may indicate a need for aggressive treatment to slow down the progression of their glaucoma.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Carolyn Guan, Mary Ellen Pease, Sarah Quillen, Yik Tung Tracy Ling, Ximin Li, Elizabeth Kimball, Thomas Johnson, Thao D. Nguyen, Harry A. Quigley
Summary: This study quantitatively measured the changes in lamina cribrosa cell and connective tissue structure in human glaucoma eyes. The results showed that in the pores of the lamina cribrosa, the proportionate area of both GFAP and F-actin processes was significantly lower in glaucoma eyes compared to controls, and the nuclei in glaucoma specimens were rounder. Furthermore, wider F-actin process width, narrower average lamina cribrosa beam width, and increased nuclear count per square millimeter were associated with worse glaucoma damage.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Ziyi Zhu, Susannah Waxman, Bo Wang, Jacob Wallace, Samantha E. Schmitt, Elizabeth Tyler-Kabara, Hiroshi Ishikawa, Joel S. Schuman, Matthew A. Smith, Gadi Wollstein, Ian A. Sigal
Summary: The study found that changes in IOP and ICP significantly deformed the scleral canal and lamina of the monkey ONH. There were individualized responses to pressure manipulation between eyes, and significant interactions between the effects of IOP and ICP on LC depth, BMO area, aspect ratio and planarity. Overall, elevating both pressures did not cancel out the effects in most eyes.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Diana C. Lozano, Hari Jayaram, William O. Cepurna, Shandiz Tehrani, Lina Gao, Suzanne S. Fei, Dongseok Choi, Elaine C. Johnson, John C. Morrison
Summary: The purpose of this study was to clarify the gene expression responses in the optic nerve head (ONH) associated with single exposure to elevated intraocular pressure (IOP) in relation to chronic models of elevated IOP. The findings showed that the gene expression changed over time in the PT-CEI model, including upregulation of defense response, cell cycle, and immune response-related genes. These results contribute to a better understanding of optic nerve damage.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Mona Safizadeh, Amirreza Shaabani, Alireza Kamalipour, Masoud Aghsaei Fard, Kaileen Yeh, Mehdi Yaseri, Nikoo Hamzeh, Nassim Khatibi, Harsha Laxmana Rao, Robert Weinreb, Sasan Moghimi
Summary: OCTA can be used to detect reduced capillary density in fellow eyes of PXG patients, enabling earlier detection of glaucomatous loss in pseudoexfoliation disease and enhancing disease management.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Immunology
Wenwen Lai, Jie Huang, Wangyi Fang, Saiyue Deng, Yi Xie, Wei Wang, Tong Qiao, Gezhi Xu, Xiaowei Wang, Fengfei Ding
Summary: This study investigates the role of optic nerve head (ONH) in defense against vitreous inflammation. The researchers found that while the retina showed signs of inflammation, the posterior optic nerve and the optic nerve head showed no signs of inflammation or infiltration of inflammatory cells. The study also found that the astrocytes in the ONH changed their spatial orientation in response to inflammation. The findings suggest that glial responses in the ONH may serve as a barrier to inflammation for the central nervous system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Casey J. Keuthan, Julie A. Schaub, Meihan Wei, Weixiang Fang, Sarah Quillen, Elizabeth Kimball, Thomas V. Johnson, Hongkai Ji, Donald J. Zack, Harry A. Quigley
Summary: The level of intraocular pressure (IOP) is a major risk factor for glaucomatous optic neuropathy. This study found that the unmyelinated optic nerve region is differentially susceptible to IOP-induced damage compared to the myelinated region. Gene expression patterns in the unmyelinated optic nerve showed significant differences compared to the myelinated optic nerve and retina. Changes in gene expression induced by optic nerve injury were more extensive in the myelinated region than the unmyelinated region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Thanadet Chuangsuwanich, Tin A. Tun, Fabian A. Braeu, Xiaofei Wang, Zhi Yun Chin, Satish K. Panda, Martin Buist, Dan Milea, Nicholas Strouthidis, Shamira Perera, Monisha Esther Nongpiur, Tin Aung, Michael J. A. Girard
Summary: This study aimed to assess the strains in optic nerve head (ONH) induced by intraocular pressure (IOP) and gaze in subjects with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). The results showed that NTG subjects experienced higher strains due to gaze, while HTG subjects experienced higher strain due to IOP elevation, and these differences were most pronounced in the lamina cribrosa (LC) tissue.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ji-Ah Kim, Eun Ji Lee, Tae-Woo Kim, Hee Kyung Yang, Jeong-Min Hwang
Summary: The microvasculature of the optic nerve head and peripapillary tissues in eyes with normal-tension glaucoma (NTG) and nonarteritic anterior ischemic optic neuropathy (NAION) was compared using optical coherence tomography angiography (OCTA). Despite similar levels of retinal nerve fiber layer loss and vessel density decreases in the peripapillary retina, there were differences in vessel densities in the optic nerve head between NTG and NAION eyes, suggesting distinct mechanisms of vascular impairment and optic nerve head damage in each condition.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Eugene A. Lowry, Steven L. Mansberger, Stuart K. Gardiner, Hongli Yang, Facundo Sanchez, Juan Reynaud, Shaban Demirel, Claude F. Burgoyne, Brad Fortune
Summary: The frequency and severity of optic nerve head prelaminar schisis were found to be greater in glaucoma and glaucoma suspect eyes compared to healthy control eyes, and were associated with markers of glaucoma severity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jiafeng Liu, Yong Yang, Yang Liu
Summary: Piezo1, a mechanosensing channel, plays a crucial role in the pathogenesis of neurodegenerative diseases in astrocytes. This study reveals that Piezo1 responds to mechanical stimulation and is involved in astrocyte reactivity in the optic nerve head.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Youichi Shinozaki, Alex Leung, Kazuhiko Namekata, Sei Saitoh, Huy Bang Nguyen, Akiko Takeda, Yosuke Danjo, Yosuke M. Morizawa, Eiji Shigetomi, Fumikazu Sano, Nozomu Yoshioka, Hirohide Takebayashi, Nobuhiko Ohno, Takahiro Segawa, Kunio Miyake, Kenji Kashiwagi, Takayuki Harada, Shin-ichi Ohnuma, Schuichi Koizumi
Summary: Loss of ABCA1 in retinal astrocytes causes glaucoma-like optic neuropathy in aged mice, leading to retinal ganglion cell degeneration and ocular dysfunction.
Article
Ophthalmology
John C. Morrison, William O. Cepurna, Elaine C. Johnson
EXPERIMENTAL EYE RESEARCH
(2015)
Article
Ophthalmology
Justin M. Risma, Shandiz Tehrani, Kai Wang, John H. Fingert, Wallace L. M. Alward, Young H. Kwon
JOURNAL OF GLAUCOMA
(2016)
Article
Ophthalmology
Hana L. Takusagawa, Liang Liu, Kelly N. Ma, Yali Jia, Simon S. Gao, Miao Zhang, Beth Edmunds, Mansi Parikh, Shandiz Tehrani, John C. Morrison, David Huang
Article
Multidisciplinary Sciences
Shandiz Tehrani, R. Katherine Delf, William O. Cepurna, Lauren Davis, Elaine C. Johnson, John C. Morrison
SCIENTIFIC REPORTS
(2018)
Review
Ophthalmology
Shandiz Tehrani
CURRENT EYE RESEARCH
(2015)
Letter
Ophthalmology
S. Tehrani, C. Rozelle, A. Solomon, E. A. Steele
Article
Ophthalmology
Elaine C. Johnson, William O. Cepurna, Dongseok Choi, Tiffany E. Choe, John C. Morrison
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)
Article
Multidisciplinary Sciences
Shandiz Tehrani, Lauren Davis, William O. Cepurna, Tiffany E. Choe, Diana C. Lozano, Ashley Monfared, Lauren Cooper, Joshua Cheng, Elaine C. Johnson, John C. Morrison
Article
Biochemical Research Methods
Zhongwei Zhi, William O. Cepurna, Elaine C. Johnson, John C. Morrison, Ruikang K. Wang
BIOMEDICAL OPTICS EXPRESS
(2012)
Letter
Ophthalmology
Anamika Tandon, Shandiz Tehrani, Mark A. Greiner, John H. Fingert, Wallace L. M. Alward
JAMA OPHTHALMOLOGY
(2014)
Article
Multidisciplinary Sciences
Shaohua Pi, Tristan T. Hormel, Xiang Wei, William Cepurna, Bingjie Wang, John C. Morrison, Yali Jia
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Ophthalmology
John C. Morrison, William O. Cepurna, Shandiz Tehrani, Tiffany E. Choe, Hari Jayaram, Diana C. Lozano, Brad Fortune, Elaine C. Johnson
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2016)
Article
Ophthalmology
Mark Zivney, Phoebe Lin, Beth Edmunds, Mansi Parikh, Hana Takusagawa, Shandiz Tehrani
OPHTHALMOLOGY AND THERAPY
(2016)