Inhibition of prenylated KRAS in a lipid environment

Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis

(2016) Priyanka Prakash et al.   BIOPHYSICAL JOURNAL

The higher level of complexity of K-Ras4B activation at the membrane

(2016) Hyunbum Jang et al.   FASEB JOURNAL

Getting a Handle on RAS-targeted Therapies: Cysteine Directed Inhibitors

(2016) Minh V. Huynh et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Direct Modulation of Small GTPase Activity and Function

(2015) Philipp M. Cromm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of Ras Signaling by Blocking Ras-Effector Interactions with Cyclic Peptides

(2015) Punit Upadhyaya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ras nanoclusters: Versatile lipid-based signaling platforms

(2015) Yong Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

(2015) Jon J. G. Winter et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of RAF protein kinases in ERK signalling

(2015) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

(2015) Mohammad T. Mazhab-Jafari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

(2015) William K. Gillette et al.   Scientific Reports

pMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound Proteins

(2015) Priyanka Prakash et al.   PLoS Computational Biology

Elucidating the Mode of Action of a Typical Ras State 1(T) Inhibitor

(2014) Ina C. Rosnizeck et al.   BIOCHEMISTRY

KRas Localizes to the Plasma Membrane by Spatial Cycles of Solubilization, Trapping and Vesicular Transport

(2014) Malte Schmick et al.   CELL

Chemical Biology Tools for Regulating RAS Signaling Complexity in Space and Time

(2014) Hilde van Hattum et al.   CHEMISTRY & BIOLOGY

Improved NMR experiments with 13C-isotropic mixing for assignment of aromatic and aliphatic side chains in labeled proteins

(2014) Helena Kovacs et al.   JOURNAL OF BIOMOLECULAR NMR

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor

(2013) Sang Min Lim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RAF Inhibitors Activate the MAPK Pathway by Relieving Inhibitory Autophosphorylation

(2013) Matthew Holderfield et al.   CANCER CELL

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins

(2013) Kenji Maeda et al.   NATURE

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function

(2013) H. J. Hocker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

(2013) F. Shima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metal-Bis(2-picolyl)amine Complexes as State 1(T) Inhibitors of Activated Ras Protein

(2012) Ina C. Rosnizeck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

(2012) Qi Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ras inhibition via direct Ras binding—is there a path forward?

(2012) Weiru Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction

(2012) Shobhna Kapoor et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras Proteins

(2012) Kwang-jin Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

(2012) T. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution Structure of the State 1 Conformer of GTP-bound H-Ras Protein and Distinct Dynamic Properties between the State 1 and State 2 Conformers

(2011) Mitsugu Araki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

(2011) Greg Buhrman et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Novel Allosteric Sites on Ras for Lead Generation

(2011) Barry J. Grant et al.   PLoS One

Stabilizing a Weak Binding State for Effectors in the Human Ras Protein by Cyclen Complexes

(2010) Ina C. Rosnizeck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conformational States of Human Rat Sarcoma (Ras) Protein Complexed with Its Natural Ligand GTP and Their Role for Effector Interaction and GTP Hydrolysis

(2010) Michael Spoerner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Automated NMR Resonance Assignment of Large Proteins for Protein−Ligand Interaction Studies

(2010) Alvar D. Gossert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assembly of the Sos1–Grb2–Gab1 ternary signaling complex is under allosteric control

(2009) Caleb B. McDonald et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Interaction of Cationic Drugs with Liposomes

(2009) Brett A. Howell et al.   LANGMUIR