Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides

DNAzyme Hybridization, Cleavage, Degradation, and Sensing in Undiluted Human Blood Serum

(2015) Wenhu Zhou et al.   ANALYTICAL CHEMISTRY

Telomere-Homologous G-Rich Oligonucleotides Sensitize Human Ovarian Cancer Cells to TRAIL-Induced Growth Inhibition and Apoptosis

(2015) Sibaji Sarkar et al.   Nucleic Acid Therapeutics

Role of G-quadruplex located at 5ʹ end of mRNAs

(2014) Prachi Agarwala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas

(2014) Liyu Li et al.   BIOMATERIALS

Cellular Uptake and Intracellular Trafficking of Oligonucleotides: Implications for Oligonucleotide Pharmacology

(2014) R.L. Juliano et al.   Nucleic Acid Therapeutics

A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma

(2013) Jonathan E. Rosenberg et al.   INVESTIGATIONAL NEW DRUGS

A Targeted, Self-Delivered, and Photocontrolled Molecular Beacon for mRNA Detection in Living Cells

(2013) Liping Qiu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aptamer imaging with Cu-64 labeled AS1411: Preliminary assessment in lung cancer

(2013) Junling Li et al.   NUCLEAR MEDICINE AND BIOLOGY

General Cell-Binding Activity of Intramolecular G-Quadruplexes with Parallel Structure

(2013) Tianjun Chang et al.   PLoS One

Enhanced Cytotoxicity from Deoxyguanosine-Enriched T-oligo in Prostate Cancer Cells

(2013) Andrew M. Rankin et al.   Nucleic Acid Therapeutics

Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo

(2013) Hang Xing et al.   Journal of Materials Chemistry B

Nucleic acid aptamers: an emerging frontier in cancer therapy

(2012) Guizhi Zhu et al.   CHEMICAL COMMUNICATIONS

Therapeutic RNA aptamers in clinical trials

(2012) Padma Sundaram et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Generating Aptamers by Cell-SELEX for Applications in Molecular Medicine

(2012) Mao Ye et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular Uptake and Intracellular Trafficking of Antisense and siRNA Oligonucleotides

(2011) Rudolph L. Juliano et al.   BIOCONJUGATE CHEMISTRY

Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA

(2011) Yan Xu   CHEMICAL SOCIETY REVIEWS

The application of DNA and RNA G-quadruplexes to therapeutic medicines

(2011) Gavin W. Collie et al.   CHEMICAL SOCIETY REVIEWS

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity

(2010) Cyril M. Sanders   BIOCHEMICAL JOURNAL

A New Paradigm for Aptamer Therapeutic AS1411 Action: Uptake by Macropinocytosis and Its Stimulation by a Nucleolin-Dependent Mechanism

(2010) E. M. Reyes-Reyes et al.   CANCER RESEARCH

Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington’s disease

(2010) Chiara Soldati et al.   JOURNAL OF NEUROCHEMISTRY

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

How long is too long? Effects of loop size on G-quadruplex stability

(2010) Aurore Guédin et al.   NUCLEIC ACIDS RESEARCH

Aptamers Generated from Cell-SELEX for Molecular Medicine: A Chemical Biology Approach

(2009) Xiaohong Fang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists

(2009) Jörg Vollmer et al.   ADVANCED DRUG DELIVERY REVIEWS

Specific DNA G-quadruplexes bind to ethanolamines

(2009) Xiaohong Cheng et al.   BIOPOLYMERS

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

(2009) Paula J. Bates et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth

(2009) Yongli Guan et al.   MOLECULAR THERAPY

Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides

(2009) Enid W. Choi et al.   NUCLEIC ACIDS RESEARCH

The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells

(2008) S. Soundararajan et al.   CANCER RESEARCH

Extracellular guanosine and GTP promote expression of differentiation markers and induce S-phase cell-cycle arrest in human SH-SY5Y neuroblastoma cells

(2008) S. Guarnieri et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

G-Quadruplex DNA Assemblies: Loop Length, Cation Identity, and Multimer Formation†

(2008) Nicolas Smargiasso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Rich Oligonucleotides Alter Cell Cycle Progression and Induce Apoptosis Specifically in OE19 Esophageal Tumor Cells

(2008) Timothy R. Schwartz et al.   OLIGONUCLEOTIDES