Nucleic acid aptamers: an emerging frontier in cancer therapy

Single-molecule atomic force microscopy on live cells compares aptamer and antibody rupture forces

(2012) Meghan B. O’Donoghue et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Self-Assembled Aptamer-Based Drug Carriers for Bispecific Cytotoxicity to Cancer Cells

(2012) Guizhi Zhu et al.   Chemistry-An Asian Journal

Designer Tridentate Mucin 1 Aptamer for Targeted Drug Delivery

(2012) Lihan Tan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

In Vitro Selection of DNA Aptamers to Glioblastoma Multiforme

(2011) Abdullah Tahir Bayrac et al.   ACS Chemical Neuroscience

Smart Multifunctional Nanostructure for Targeted Cancer Chemotherapy and Magnetic Resonance Imaging

(2011) Tao Chen et al.   ACS Nano

Near-Infrared Light-Responsive Core–Shell Nanogels for Targeted Drug Delivery

(2011) Huaizhi Kang et al.   ACS Nano

Release of Photoactivatable Drugs from Plasmonic Nanoparticles for Targeted Cancer Therapy

(2011) Yun-Ling Luo et al.   ACS Nano

Self-Assembly of a Bifunctional DNA Carrier for Drug Delivery

(2011) Kelong Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A G-Quadruplex Aptamer Inhibits the Phosphatase Activity of Oncogenic Protein Shp2 in vitro

(2011) Jia Hu et al.   CHEMBIOCHEM

A Novel Aptamer Developed for Breast Cancer Cell Internalization

(2011) Kejing Zhang et al.   ChemMedChem

Nucleic acid based tools for pharmacology and nano-engineering

(2011) Martin Müller et al.   COMPTES RENDUS CHIMIE

Bi-specific Aptamers Mediating Tumor Cell Lysis

(2011) Achim Boltz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer

(2011) Ronak Savla et al.   JOURNAL OF CONTROLLED RELEASE

Engineering Polymeric Aptamers for Selective Cytotoxicity

(2011) Liu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pharma interest surges in antibody drug conjugates

(2011) Sarah Webb   NATURE BIOTECHNOLOGY

Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo

(2011) Shanta Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration

(2011) H. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Cell-Cell Interactions by DNA Nanoscaffold-Templated Multivalent Bispecific Aptamers

(2011) Xiaowei Liu et al.   Small

Molecular aptamers for drug delivery

(2011) Weihong Tan et al.   TRENDS IN BIOTECHNOLOGY

Aptamer-Based Tumor-Targeted Drug Delivery for Photodynamic Therapy

(2010) Yen-An Shieh et al.   ACS Nano

A Drug-Loaded Aptamer−Gold Nanoparticle Bioconjugate for Combined CT Imaging and Therapy of Prostate Cancer

(2010) Dongkyu Kim et al.   ACS Nano

Aptamers Recognizing Glycosylated Hemagglutinin Expressed on the Surface of Vaccinia Virus-Infected Cells

(2010) Parag Parekh et al.   ANALYTICAL CHEMISTRY

ADLOC: An Aptamer-Displacement Assay Based on Luminescent Oxygen Channeling

(2010) Björn Niebel et al.   CHEMISTRY-A EUROPEAN JOURNAL

DNA-Based Micelles: Synthesis, Micellar Properties and Size-Dependent Cell Permeability

(2010) Haipeng Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

In vivo Fluorescence Imaging of Tumors using Molecular Aptamers Generated by Cell-SELEX

(2010) Hui Shi et al.   Chemistry-An Asian Journal

Development of DNA aptamers using Cell-SELEX

(2010) Kwame Sefah et al.   Nature Protocols

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures

(2010) Günter Mayer et al.   Nature Protocols

Antibody–drug conjugates for cancer: poised to deliver?

(2010) Bethan Hughes   NATURE REVIEWS DRUG DISCOVERY

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia

(2010) Prabodhika R. Mallikaratchy et al.   NUCLEIC ACIDS RESEARCH

Aptamers Generated from Cell-SELEX for Molecular Medicine: A Chemical Biology Approach

(2009) Xiaohong Fang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recognition of subtype non-small cell lung cancer by DNA aptamers selected from living cells

(2009) Zilong Zhao et al.   ANALYST

Aptamer-Based Microfluidic Device for Enrichment, Sorting, and Detection of Multiple Cancer Cells

(2009) Ye Xu et al.   ANALYTICAL CHEMISTRY

Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes

(2009) Zehui Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies

(2009) Laurent Ducry et al.   BIOCONJUGATE CHEMISTRY

A RNA-Based Approach towards Small-Molecule Inhibitors

(2009) Günter Mayer et al.   CHEMBIOCHEM

Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells

(2009) Yu-Fen Huang et al.   CHEMBIOCHEM

Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform

(2009) Prabodhika Mallikaratchy et al.   CHEMICAL COMMUNICATIONS

A liposome-based nanostructure for aptamer directed delivery

(2009) Huaizhi Kang et al.   CHEMICAL COMMUNICATIONS

Generating Aptamers for Recognition of Virus-Infected Cells

(2009) Z. Tang et al.   CLINICAL CHEMISTRY

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

(2009) Paula J. Bates et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Exploring Chemical Space with Aptamers

(2009) Michael Famulok   JOURNAL OF MEDICINAL CHEMISTRY

Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles

(2009) Gary J. Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular recognition of acute myeloid leukemia using aptamers

(2009) K Sefah et al.   LEUKEMIA

Plasma Membrane Nucleolin Is a Receptor for the Anticancer Aptamer AS1411 in MV4-11 Leukemia Cells

(2009) S. Soundararajan et al.   MOLECULAR PHARMACOLOGY

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology

Development of universal antidotes to control aptamer activity

(2009) Sabah Oney et al.   NATURE MEDICINE

Anti-MUC1 aptamers: radiolabelling with 99mTc and biodistribution in MCF-7 tumour-bearing mice

(2009) Chiara Da Pieve et al.   NUCLEAR MEDICINE AND BIOLOGY

Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides

(2009) Enid W. Choi et al.   NUCLEIC ACIDS RESEARCH

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

Antimetastatic Potential of PAI-1–Specific RNA Aptamers

(2009) Charlene M. Blake et al.   OLIGONUCLEOTIDES

DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells

(2009) Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex Target SELEX

(2008) Steven M. Shamah et al.   ACCOUNTS OF CHEMICAL RESEARCH

Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells

(2008) Dihua Shangguan et al.   ANALYTICAL CHEMISTRY

Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis

(2008) Won-Sik Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells

(2008) S. Soundararajan et al.   CANCER RESEARCH

Molecular Recognition of Small-Cell Lung Cancer Cells Using Aptamers

(2008) Hui William Chen et al.   ChemMedChem

Cell-Specific Aptamer Probes for Membrane Protein Elucidation in Cancer Cells

(2008) Dihua Shangguan et al.   JOURNAL OF PROTEOME RESEARCH

Selective Photothermal Therapy for Mixed Cancer Cells Using Aptamer-Conjugated Nanorods

(2008) Yu-Fen Huang et al.   LANGMUIR

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization

(2008) Markus Hafner et al.   Nature Protocols

Exploring TAR–RNA aptamer loop–loop interaction by X-ray crystallography, UV spectroscopy and surface plasmon resonance

(2008) Isabelle Lebars et al.   NUCLEIC ACIDS RESEARCH

Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers

(2008) F. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of an RNA aptamer bound to thrombin

(2008) S. B. Long et al.   RNA

Cell Specific Aptamer–Photosensitizer Conjugates as a Molecular Tool in Photodynamic Therapy

(2007) Prabodhika Mallikaratchy et al.   ChemMedChem