Oligomeric Aβ1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function

Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina

(2020) Haoshen Shi et al.   ACTA NEUROPATHOLOGICA

Misfolded amyloid-β-42 impairs the endosomal–lysosomal pathway

(2020) Karen E. Marshall et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Senescence in the pathogenesis of age-related macular degeneration

(2020) Janusz Blasiak   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxidative Stress and Dysfunctional Intracellular Traffic Linked to an Unhealthy Diet Results in Impaired Cargo Transport in the Retinal Pigment Epithelium (RPE)

(2019) Eloise Keeling et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Cytoskeleton of the Retinal Pigment Epithelium: from Normal Aging to Age-Related Macular Degeneration

(2019) Ioana-Sandra Tarau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A lasered mouse model of retinal degeneration displays progressive outer retinal pathology providing insights into early geographic atrophy

(2019) Paul Ibbett et al.   Scientific Reports

Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors

(2019) Khanh V. Do et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina

(2019) Shoji Notomi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The retina as a window to early dysfunctions of Alzheimer's disease following studies with a 5xFAD mouse model

(2018) Chiara Criscuolo et al.   NEUROBIOLOGY OF AGING

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases

(2018) Eloise Keeling et al.   Cells

Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy

(2018) Niina Piippo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The complexities underlying age-related macular degeneration: could amyloid beta play an important role?

(2017) JArjuna Ratnayaka et al.   Neural Regeneration Research

Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration

(2017) Frank G. Holz et al.   OPHTHALMOLOGY

Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE

(2017) Savannah A. Lynn et al.   TISSUE & CELL

Dry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis

(2017) Sung Wook Park et al.   Oncotarget

Differential Accumulation of Secreted AβPP Metabolites in Ocular Fluids

(2017) Annamalai Prakasam et al.   JOURNAL OF ALZHEIMERS DISEASE

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration

(2016) Deborah A. Ferrington et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Retinal amyloid peptides and complement factor H in transgenic models of Alzheimerʼs disease

(2016) Peter N. Alexandrov et al.   NEUROREPORT

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin

(2015) Rajni Parthasarathy et al.   EXPERIMENTAL EYE RESEARCH

Dementia of the eye: the role of amyloid beta in retinal degeneration

(2015) J A Ratnayaka et al.   EYE

Plasma levels of amyloid beta and other proinflammatory mediators in patients with age-related macular degeneration

(2015) Robyn Guymer et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation

(2015) James R. Edgar et al.   JOURNAL OF CELL SCIENCE

Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye

(2015) Richard B. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium

(2015) Sung Wook Park et al.   Oncotarget

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1

(2015) Anita Ramanathan et al.   Frontiers in Aging Neuroscience

Understanding photoreceptor outer segment phagocytosis: Use and utility of RPE cells in culture

(2014) Francesca Mazzoni et al.   EXPERIMENTAL EYE RESEARCH

Subretinal injection of amyloid-β peptide accelerates RPE cell senescence and retinal degeneration

(2014) CHAOQI LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Evaluation of cathepsin B activity for degrading collagen IV using a surface plasmon resonance method and circular dichroism spectroscopy

(2014) Atsushi Shoji et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice

(2014) Sung Wook Park et al.   NEUROBIOLOGY OF AGING

Geographic Atrophy

(2014) Frank G. Holz et al.   OPHTHALMOLOGY

Lysosome Transport as a Function of Lysosome Diameter

(2014) Debjyoti Bandyopadhyay et al.   PLoS One

An introduction to the wound healing assay using live-cell microscopy

(2014) James E. N. Jonkman et al.   Cell Adhesion & Migration

Systemic Administration of Abeta mAb Reduces Retinal Deposition of Abeta and Activated Complement C3 in Age-Related Macular Degeneration Mouse Model

(2013) Ian Catchpole et al.   PLoS One

Elevated amyloid β production in senescent retinal pigment epithelium, a possible mechanism of subretinal deposition of amyloid β in age-related macular degeneration

(2012) Jiying Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death

(2011) Violetta Soura et al.   BIOCHEMICAL JOURNAL

Selection of Candidate Housekeeping Genes for Normalization in Human Postmortem Brain Samples

(2011) Ilaria Penna et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration

(2011) J.-D. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parallel findings in age-related macular degeneration and Alzheimer’s disease

(2011) Kyoko Ohno-Matsui   PROGRESS IN RETINAL AND EYE RESEARCH

The bisretinoids of retinal pigment epithelium

(2011) Janet R. Sparrow et al.   PROGRESS IN RETINAL AND EYE RESEARCH

A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease

(2011) K. Broersen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The electroretinogram: a useful tool for evaluating age-related macular disease?

(2010) Emma J. Berrow et al.   DOCUMENTA OPHTHALMOLOGICA

Membrane Localization of β-Amyloid 1–42 in Lysosomes

(2010) Rui-Qin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viewing Ageing Eyes: Diverse Sites of Amyloid Beta Accumulation in the Ageing Mouse Retina and the Up-Regulation of Macrophages

(2010) Jaimie Hoh Kam et al.   PLoS One

Amyloid-β(1-42) alters structure and function of retinal pigmented epithelial cells

(2009) Julien Bruban et al.   AGING CELL

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomer-specific Aβ toxicity in cell models is mediated by selective uptake

(2008) Sidhartha M. Chafekar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE