Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence

Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MS

(2014) Michiyo Okudaira et al.   JOURNAL OF LIPID RESEARCH

Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy

(2014) Masayuki Nagahashi et al.   Biomed Research International

Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids

(2013) Akio Kihara   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential

(2013) Baasanjav Uranbileg et al.   INTERNATIONAL JOURNAL OF CANCER

A Metabolic Shift Favoring Sphingosine 1-Phosphate at the Expense of Ceramide Controls Glioblastoma Angiogenesis

(2013) Hazem J. Abuhusain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability

(2013) Karen Rex et al.   PLoS One

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

(2012) Mark E. Schnute et al.   BIOCHEMICAL JOURNAL

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents

(2012) Yuko Kageyama et al.   HEPATOLOGY

First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer

(2012) L. Brizuela et al.   MOLECULAR CANCER THERAPEUTICS

Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate

(2011) Yugesh Kharel et al.   BIOCHEMICAL JOURNAL

Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts

(2011) Vladimir Beljanski et al.   CANCER BIOLOGY & THERAPY

Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma

(2011) Meiyan Bao et al.   LIVER INTERNATIONAL

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility

(2010) Changyong Li et al.   JOURNAL OF HEPATOLOGY

Involvement of Sphingosine 1-Phosphate (SIP)/S1P 3 Signaling in Cholestasis-Induced Liver Fibrosis

(2009) Changyong Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis

(2009) Changyong Li et al.   JOURNAL OF HEPATOLOGY

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2

(2008) Hitoshi Ikeda et al.   JOURNAL OF LIPID RESEARCH

Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions

(2008) Michael G. Bayerl et al.   LEUKEMIA & LYMPHOMA