Unaltered Prion Pathogenesis in a Mouse Model of High-Fat Diet-Induced Insulin Resistance

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin resistance predicts brain amyloid deposition in late middle-aged adults

(2015) Auriel A. Willette et al.   Alzheimers & Dementia

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents

(2015) Dmitry Petrov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structure-based drug design identifies polythiophenes as antiprion compounds

(2015) Uli S. Herrmann et al.   Science Translational Medicine

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Diabetes Mellitus Accelerates Aβ Pathology in Brain Accompanied by Enhanced GAβ Generation in Nonhuman Primates

(2015) Sachi Okabayashi et al.   PLoS One

Down regulation of brain cellular prion protein in an animal model of insulin resistance: Possible implication in increased prevalence of stroke in pre-diabetics/diabetics

(2014) Nam Pham et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin Reverses the High-Fat Diet-Induced Increase in Brain A  and Improves Memory in an Animal Model of Alzheimer Disease

(2014) M. Vandal et al.   DIABETES

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

(2013) Tiziana Sonati et al.   NATURE

Prions disturb post-Golgi trafficking of membrane proteins

(2013) Keiji Uchiyama et al.   Nature Communications

Insulin Resistance, Brain Atrophy, and Cognitive Performance in Late Middle-Aged Adults

(2012) A. A. Willette et al.   DIABETES CARE

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes

(2012) Naoki Yamamoto et al.   JOURNAL OF NEUROCHEMISTRY

Five Questions on Prion Diseases

(2012) Adriano Aguzzi et al.   PLoS Pathogens

Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures

(2012) Jeppe Falsig et al.   PLoS Pathogens

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Association of Metabolic Dysregulation With Volumetric Brain Magnetic Resonance Imaging and Cognitive Markers of Subclinical Brain Aging in Middle-Aged Adults

(2011) Zaldy S. Tan et al.   DIABETES CARE

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Glucose tolerance status and risk of dementia in the community: The Hisayama Study

(2011) T. Ohara et al.   NEUROLOGY

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Axonal prion protein is required for peripheral myelin maintenance

(2010) Juliane Bremer et al.   NATURE NEUROSCIENCE

Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

(2010) E. M. C. Schrijvers et al.   NEUROLOGY

Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study

(2010) S. Ahtiluoto et al.   NEUROLOGY

Impaired Glucose Tolerance in Mice Lacking Cellular Prion Protein

(2010) Alexander Strom et al.   PANCREAS

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders

(2009) Louis A. Profenno et al.   BIOLOGICAL PSYCHIATRY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Prion Strain Discrimination Based on Rapid In Vivo Amplification and Analysis by the Cell Panel Assay

(2009) Yervand Eduard Karapetyan et al.   PLoS One

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

The POM Monoclonals: A Comprehensive Set of Antibodies to Non-Overlapping Prion Protein Epitopes

(2008) Magdalini Polymenidou et al.   PLoS One

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL