Review
Biochemistry & Molecular Biology
Eijiro Jimi, Takenobu Katagiri
Summary: The NF-kappa B transcription factor family plays important roles in inflammation, immune response, and bone metabolism. Its activation occurs through different pathways and is crucial for osteoclast differentiation. Recent studies have identified genetic mutations in NF-kappa B signaling molecules associated with diseases like osteopetrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Zhichu Chen, Dong Huang, Prakaiwan Yongyut, Guangbin Li, Maria Angeles Esteban, Orapint Jintasataporn, Junming Deng, Wenbing Zhang, Qinghui Ai, Kangsen Mai, Yanjiao Zhang
Summary: This study found that VD3 deficiency leads to increased intestinal inflammation, apoptosis, and autophagy in teleosts. VDR plays a critical role in these processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Reema Jain, Kelin Zhao, Julie M. Sheridan, Melanie Heinlein, Fiona Kupresanin, Waruni Abeysekera, Cathrine Hall, James Rickard, Philippe Bouillet, Henning Walczak, Andreas Strasser, John Silke, Daniel H. D. Gray
Summary: The study reveals the crucial role of the linear ubiquitin chain assembly complex in thymic epithelial cell differentiation and survival, with deficiency in LUBAC proteins severely impacting thymic tissue expansion and cell survival, potentially leading to premature thymic atrophy.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Peter F. Surai, Ivan I. Kochish, Michael T. Kidd
Summary: Redox biology is a rapidly developing field in modern biological sciences, with a focus on the roles of redox homeostasis in health and disease. Various redox pairs in cells/tissues are responsible for maintaining/regulating redox balance, with Nrf2 identified as a key regulator. The interactions between vitagenes and NF-kappa B in relation to redox balance, immunity, and gut health in poultry production require further research to better understand their impact on stress-related disturbances.
Review
Pharmacology & Pharmacy
Md Sahab Uddin, Md Tanvir Kabir, Abdullah Al Mamun, Md Shahid Sarwar, Fatema Nasrin, Talha Bin Emran, Ibtesam S. Alanazi, Abdur Rauf, Ghadeer M. Albadrani, Amany A. Sayed, Shaker A. Mousa, Mohamed M. Abdel-Daim
Summary: NF-κB is a critical transcription factor that is abnormally activated in several cancers, particularly in glioblastoma multiforme (GBM). Despite the use of various treatment modalities for GBM, the survival rate of patients remains low, highlighting the need for new therapeutic approaches.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Article
Pharmacology & Pharmacy
Guangxia Yang, Kai Wang, Hua Song, Rujie Zhu, Shuai Ding, Hui Yang, Jian Sun, Xin Wen, Lingyun Sun
Summary: This study investigated the effect of celastrol on osteoarthritis (OA) and identified the mechanisms involved. The results showed that celastrol delayed cartilage damage, reduced osteophyte formation and bone resorption in an OA rat model. In vitro experiments also demonstrated that celastrol suppressed the production of inflammatory factors and inhibited matrix degradation. Furthermore, celastrol inhibited the TLR2/NF-kappa B signaling pathway. These findings suggest that celastrol could be a potential therapy for OA by targeting this signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Alfy Benny, Remya Ramakrishnan, Mahesh Hariharan
Summary: The study reveals that the Greek cross (+) stacked orientation exhibits mutually exclusive hole and electron transfer couplings in any molecular candidate, independent of the nature of the monomer. Additionally, the Greek cross (+) stacks of the considered acene candidates exhibit selective charge carrier mobility in the hopping regime of charge transport.
Article
Pharmacology & Pharmacy
Li-Na Xu, Shu-Hui Wang, Xue-Ling Su, Sumra Komal, Hong-Kun Fan, Li Xia, Li-Rong Zhang, Sheng-Na Han
Summary: The study investigated the effects of the GSK-3 beta/NF-kappa B pathway on CD47 expression after MI in rats. Results showed that GSK-3 beta upregulates CD47 expression by activating NF-kappa B, leading to myocardial cell damage and apoptosis. SB216763 and the NF-kappa B inhibitor SN50 were found to reduce CD47 expression and apoptosis in hypoxic conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Jing Zhang, Yu-Jing Wu, Xiao-Xi Hu, Wei Wei
Summary: Lck and nuclear factor-kappa B play crucial roles in the development and progression of autoimmune diseases and malignancies, and understanding their signaling pathways may lead to the identification of new therapeutic targets and approaches.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu
Summary: This study confirmed that cytoplasmic protein TRAF2 can be methylated by SMYD2 and contribute to the continuous activation of NF-kappa B signaling pathway. Knocking down SMYD2 showed varying degrees of mitigation in acute and chronic inflammation mouse models. Moreover, lysine-specific demethylase LSD1 was found to resist the methylation of TRAF2 induced by SMYD2.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Qianhui Chen, Xinyu Lu, Xiaoyong Zhang
Summary: The noncanonical NF-kappa B signaling pathway plays a crucial role in regulating inflammation and immune response, showing potential therapeutic value against liver diseases. Activation of this pathway may contribute to viral clearance, with specific inhibitors and antibodies currently under development and testing.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Cell Biology
Seungjin Ryu, Jeehae Han, Trina M. Norden-Krichmar, Quanwei Zhang, Seunggeun Lee, Zhengdong Zhang, Gil Atzmon, Laura J. Niedernhofer, Paul D. Robbins, Nir Barzilai, Nicholas J. Schork, Yousin Suh
Summary: Gene variants associated with longevity were found to be enriched in the nPKC and NF-kappa B signaling pathways, with non-coding variants modulating the expression of cognate genes to reduce signaling. This matches genetic studies in other model organisms and suggests evolutionary conservation of reduced PKC and NF-kappa B signaling in exceptional longevity, possibly including humans.
Review
Immunology
Zilong Wang, Chucun Fang, Mengting Yao, Dongwen Wu, Maga Chen, Tianting Guo, Jianwen Mo
Summary: Venous thromboembolism is a common and costly health problem. Deep-vein thrombosis can cause severe consequences. Inflammatory response is considered an important pathway for triggering venous thromboembolism, and regulating it through the NF-kappa B signaling pathway may provide new solutions for prevention and treatment of thrombosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Myoung Woo Lee, Dae Seong Kim, Ji Eun Eom, Ji Won Lee, Ki Woong Sung, Hong Hoe Koo, Young Bin Hong, Keon Hee Yoo
Summary: This study evaluated the role of ERK2 and NF-kappa B in TRAIL cytotoxicity during cisplatin treatment. The findings suggest that induced ERK2 activity enhances TRAIL susceptibility via DR5 expression, while basal ERK2 activity suppresses TRAIL-R expression. The ERK2/NF-kappa B signaling pathway has a dual role in TRAIL susceptibility by differentially regulating TRAIL-R expression in the same cellular system.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Microscopy
Thomas A. A. Phillips, Valeria Caprettini, Nandini Aggarwal, Stefania Marcotti, Rob Tetley, Yanlan Mao, Tanya Shaw, Ciro Chiappini, Maddy Parsons, Susan Cox
Summary: Multicellular tumour cell spheroids embedded within 3D hydrogels or extracellular matrices are used as cancer models. UV photolithography is used to create PDMS stamps for generating well-like structures for precise positioning of spheroids. This method allows for reproducible high-/super-resolution live imaging.
JOURNAL OF MICROSCOPY
(2023)
Article
Oncology
Anna Aakula, Aleksi Isomursu, Christian Rupp, Andrew Erickson, Nikhil Gupta, Otto Kauko, Pragya Shah, Artur Padzik, Yuba Raj Pokharel, Amanpreet Kaur, Song-Ping Li, Lloyd Trotman, Pekka Taimen, Antti Rannikko, Jan Lammerding, Ilkka Paatero, Tuomas Mirtti, Johanna Ivaska, Jukka Westermarck
Summary: This study found that prostate cancer tumors with concomitant inhibition of PP2A and PTEN are particularly aggressive, with low patient survival rates. Overexpression of PME-1 inhibits anoikis in PTEN-deficient prostate cancer cells. The results suggest that PME-1 may be a candidate biomarker for particularly aggressive PTEN-deficient prostate cancer.
MOLECULAR ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kimi Azad, Delphine Guilligay, Cecile Boscheron, Sourav Maity, Nicola De Franceschi, Guidenn Sulbaran, Gregory Effantin, Haiyan Wang, Jean-Philippe Kleman, Patricia Bassereau, Guy Schoehn, Wouter H. Roos, Ambroise Desfosses, Winfried Weissenhorn
Summary: This study presents cryo-EM structures of membrane-coated CHMP2A-CHMP3 filaments from Homo sapiens, which reveal helical filaments assembled by CHMP2A-CHMP3 heterodimers in the open ESCRT-III conformation. Inter-filament interactions are electrostatic, facilitating filament sliding upon VPS4-mediated polymer remodeling. Fluorescence microscopy and high-speed atomic force microscopy imaging confirm that VPS4 can constrict and cleave CHMP2A-CHMP3 membrane tubes. It is concluded that CHMP2A-CHMP3-VPS4 act as a minimal membrane fission machinery.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Dermatology
Chuin Y. Ung, Alasdair Warwick, Alexandros Onoufriadis, Jonathan N. Barker, Maddy Parsons, John A. McGrath, Tanya J. Shaw, Nick Dand
Summary: This study evaluated established comorbidities of excessive scarring in European individuals and identified novel comorbidities using a phenome-wide association study. The results showed associations between excessive scarring and hypertension and atopic eczema. This study validated common comorbidities of excessive scarring and provided a reference for future studies on underlying pathophysiological mechanisms.
Article
Immunology
James H. A. Clubb, Tatiana V. Kudling, Mykhailo Girych, Lyna Haybout, Santeri Pakola, Firas Hamdan, Victor Cervera-Carrascon, Annabrita Hemmes, Susanna Gronberg-Vaha-Koskela, Joao Manuel Santos, Dafne C. A. Quixabeira, Saru Basnet, Camilla Heinio, Victor Arias, Elise Jirovec, Shreyas Kaptan, Riikka Havunen, Suvi Sorsa, Abdullah Erikat, Joel Schwartz, Marjukka Anttila, Katri Aro, Tapani Viitala, Ilpo Vattulainen, Vincenzo Cerullo, Anna Kanerva, Akseli Hemminki
Summary: A Syrian hamster anti-PD-L1 monoclonal antibody was developed and combined with an oncolytic adenovirus to evaluate safety and efficacy. The antibody was found to control tumor growth in a hamster model of pancreatic ductal adenocarcinoma, and the combination therapy further improved tumor growth control.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Claudia Owczarek, Yassmin Elmasry, Maddy Parsons
Summary: Coxsackievirus and adenovirus receptor (CAR) is a crucial cell-cell adhesion receptor that plays a key role in maintaining epithelial barrier integrity and mediating immune cell transmigration across epithelial tissues. CAR is emerging as a potential mediator of tumorigenesis and a target for viral therapy delivery on cancer cells, but its function is tightly regulated and the contributions to disease progression are likely to be context specific.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2023)
Article
Chemistry, Medicinal
Bart M. H. Bruininks, Tsjerk A. Wassenaar, Ilpo Vattulainen
Summary: In molecular simulations, periodic boundary conditions are commonly used to avoid surface effects. However, this can result in broken molecular assemblies which complicates data interpretation. To address this issue, we propose MDVWhole, an open-source algorithm capable of repairing broken assemblies caused by periodic boundary conditions. This method is efficient and suitable for processing both individual simulation frames and long trajectories with millions of points.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Physical
Balazs Fabian, Ilpo Vattulainen, Matti Javanainen
Summary: The shear viscosity of lipid membranes is crucial for determining the rates of diffusion-limited reactions and the movement of lipids, proteins, and other membrane constituents. This study uses molecular dynamics simulations to extract the shear viscosities of lipid membranes under various conditions. The results demonstrate the significant effects of protein concentration, cholesterol concentration, and temperature on membrane viscosity.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Article
Dermatology
Sofia Endzhievskaya, Chao-Kai Hsu, Hsing-San Yang, Hsin-Yu Huang, Yu-Chen Lin, Yi-Kai Hong, John Y. W. Lee, Alexandros Onoufriadis, Takuya Takeichi, Julia Yu-Yun Lee, Tanya J. Shaw, John A. McGrath, Maddy Parsons
Summary: Dermatofibromas (DFs) are common, benign fibrous skin tumors that can occur at any skin site. In some cases, DFs are multiple and familial, but the mechanisms leading to these lesions are currently unclear. This study identified a variant in the RND3 gene that encodes the small GTPase RhoE, and loss of RhoE function was found to enhance collagen activation and integrin activation, resulting in a disorganized extracellular matrix and contributing to the development of DF.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Cell Biology
Lena Bruecker, Stefanie Kornelia Becker, Vanessa Maissl, Gregory Harms, Maddy Parsons, Helen Louise May-Simera
Summary: Primary cilia are important for cellular communication and defects in cilia development or function are associated with genetic disorders. Recent research suggests that ciliary proteins are involved in actin regulation, but the exact nature of their interconnection is not fully understood.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Frederic Li Mow Chee, Bruno Beernaert, Billie G. C. Griffith, Alexander E. P. Loftus, Yatendra Kumar, Jimi C. Wills, Martin Lee, Jessica Valli, Ann P. Wheeler, J. Douglas Armstrong, Maddy Parsons, Irene M. Leigh, Charlotte M. Proby, Alex von Kriegsheim, Wendy A. Bickmore, Margaret C. Frame, Adam Byron
Summary: In this study, the authors discovered that the integrin adhesome undergoes systems-level changes in cutaneous squamous cell carcinoma cells. They also found that the actin regulator Mena plays an important role in force transmission at the nuclear envelope, regulating nuclear architecture, chromatin organization, and gene expression.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Jennifer Rynne, Elena Ortiz-Zapater, Dustin C. Bagley, Onofrio Zanin, George Doherty, Varsha Kanabar, Jon Ward, David J. Jackson, Maddy Parsons, Jody Rosenblatt, Ian M. Adcock, Rocio T. Martinez-Nunez
Summary: The article discusses the importance of asthma as the most common chronic inflammatory disease of the airways. It focuses on the expression and potential role of the TTP family of RNA binding proteins in asthma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Meeting Abstract
Biophysics
Franziska Ragaller, Luca Andronico, Jan Sykora, Waldemar Kulig, Tomasz Rog, Yagmur B. Urem, Abhinav Abhinav, Dmytro I. Danylchuk, Martin Hof, Andrey S. Klymchenko, Mariana Amaro, Ilpo Vattulainen, Erdinc Sezgin
BIOPHYSICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Melanie A. Mcdowell, Michael Heimes, Giray Enkavi, Akos Farkas, Daniel Saar, Klemens Wild, Blanche Schwappach, Ilpo Vattulainen, Irmgard Sinning
Summary: This study reveals the structure and functional characteristics of the guided entry of tail-anchored proteins (GET) insertase, including its remodeling of the membrane environment to promote substrate insertion.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Cell Biology
M. Lerche, M. Mathieu, L. Malerod, N. Pedersen, H. Hamidi, M. Chastney, B. Bruininks, S. Kaptan, G. Jacquemet, I. Vattulainen, P. Roca-Cusachs, A. Brech, F. Perez, G. Boncompain, S. Miserey, J. Ivaska
MOLECULAR BIOLOGY OF THE CELL
(2023)
