FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes

A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII

(2014) S. A. Fahs et al.   BLOOD

Murine coagulation factor VIII is synthesized in endothelial cells

(2014) L. A. Everett et al.   BLOOD

Recombinant factor VIII Fc fusion protein: extended-interval dosing maintains low bleeding rates and correlates with von Willebrand factor levels

(2014) A. D. Shapiro et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy

(2013) D. Lillicrap   BLOOD

A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models

(2013) H. R. Stennicke et al.   BLOOD

The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels

(2013) N. Rydz et al.   BLOOD

Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A

(2013) J. Mahlangu et al.   BLOOD

von Willebrand factor contributes to longer half-life of PEGylated factor VIIIin vivo

(2013) L. Tang et al.   HAEMOPHILIA

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

(2012) J. A. Dumont et al.   BLOOD

Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients

(2012) J. S. Powell et al.   BLOOD

Macrophage LRP1 contributes to the clearance of von Willebrand factor

(2012) G. Rastegarlari et al.   BLOOD

Cross-presentation of IgG-containing immune complexes

(2012) Kristi Baker et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intravascular recovery of VWF and FVIII following intraperitoneal injection and differences from intravenous and subcutaneous injection in mice

(2012) Q. SHI et al.   HAEMOPHILIA

Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis

(2012) S. KANAJI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Biochemical and functional characterization of a recombinant monomeric factor VIII-Fc fusion protein

(2012) R. T. PETERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Modern haemophilia care

(2012) Erik Berntorp et al.   LANCET

Monoclonal antibodies directed against human FcRn and their applications

(2012) Gregory J. Christianson et al.   mAbs

Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels

(2011) Guillemette Antoni et al.   BMC Medical Genetics

Strategies for extended serum half-life of protein therapeutics

(2011) Roland E Kontermann   CURRENT OPINION IN BIOTECHNOLOGY

Neonatal Fc receptor and IgG-based therapeutics

(2011) Timothy T. Kuo et al.   mAbs

The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner

(2010) Kyosuke Nakata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prolonged activity of factor IX as a monomeric Fc fusion protein

(2010) R. T. Peters et al.   BLOOD

Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment

(2010) B. Mei et al.   BLOOD

Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor

(2010) Nicholas L. Smith et al.   CIRCULATION

Factor VIII and von Willebrand factor - too sweet for their own good

(2010) P. J. LENTING et al.   HAEMOPHILIA

Neonatal Fc Receptor: From Immunity to Therapeutics

(2010) Timothy T. Kuo et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice

(2010) Manabu Kinoshita et al.   JOURNAL OF HEPATOLOGY

The “normal” factor VIII concentration in plasma

(2010) Saulius Butenas et al.   THROMBOSIS RESEARCH

Laboratory Diagnosis and Molecular Classification of von Willebrand Disease

(2009) Alain Gadisseur et al.   ACTA HAEMATOLOGICA

An FcRn-Dependent Role for Anti-flagellin Immunoglobulin G in Pathogenesis of Colitis in Mice

(2009) Kanna Kobayashi et al.   GASTROENTEROLOGY

Factor VIII and von Willebrand factor interaction: biological, clinical and therapeutic importance

(2009) V. TERRAUBE et al.   HAEMOPHILIA

Splenic marginal zone antigen-presenting cells are critical for the primary allo-immune response to therapeutic factor VIII in hemophilia A

(2009) A. NAVARRETE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Bio-distribution of pharmacologically administered recombinant factor VIIa (rFVIIa)

(2009) R. GOPALAKRISHNAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

(2009) Héctor Pérez Montoyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo

(2008) C. J. van Schooten et al.   BLOOD

The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer

(2008) E Wisse et al.   GENE THERAPY

The disappearing act of factor VIII

(2008) P. J. LENTING et al.   HAEMOPHILIA

Dependence of antibody-mediated presentation of antigen on FcRn

(2008) S.-W. Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA