Janus-like effects of type I interferon in autoimmune diseases

IFN-α Enhances IL-22 Receptor Expression in Keratinocytes: A Possible Role in the Development of Psoriasis

(2012) Mikiko Tohyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein

(2012) Katja Herges et al.   Multiple Sclerosis Journal

Serum IL-17F does not predict poor response to IM IFN -1a in relapsing-remitting MS

(2012) S. E. Bushnell et al.   NEUROLOGY

Advances in the treatment of moderate-to-severe plaque psoriasis

(2011) R. N. Herrier   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Safety profile and clinical activity of sifalimumab, a fully human anti-interferon   monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study

(2011) J. T. Merrill et al.   ANNALS OF THE RHEUMATIC DISEASES

Plasmacytoid Dendritic Cells: Recent Progress and Open Questions

(2011) Boris Reizis et al.   Annual Review of Immunology

Successful Treatment of Subacute Lupus Erythematosus With Ustekinumab

(2011) Aieska De Souza   ARCHIVES OF DERMATOLOGY

Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus

(2011) Paula S. Ramos et al.   ARTHRITIS AND RHEUMATISM

Immunotherapeutic effects of IL-7 during a chronic viral infection in mice

(2011) S. G. Nanjappa et al.   BLOOD

Fingolimod for Multiple Sclerosis: Mechanism of Action, Clinical Outcomes, and Future Directions

(2011) Matthias Mehling et al.   Current Neurology and Neuroscience Reports

IL-22 and TNF-α represent a key cytokine combination for epidermal integrity during infection withCandida albicans

(2011) Stefanie Eyerich et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neutrophils Produce Interleukin 17A (IL-17A) in a Dectin-1- and IL-23-Dependent Manner during Invasive Fungal Infection

(2011) Jessica L. Werner et al.   INFECTION AND IMMUNITY

Interleukin-17-secreting T cells in neuromyelitis optica and multiple sclerosis during relapse

(2011) H.H. Wang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

CD4 and CD8 T Cell Immune Activation during Chronic HIV Infection: Roles of Homeostasis, HIV, Type I IFN, and IL-7

(2011) M. Catalfamo et al.   JOURNAL OF IMMUNOLOGY

Frequency and Magnitude of Interferon β Neutralizing Antibodies in the Evaluation of Interferon β Immunogenicity in Patients with Multiple Sclerosis

(2011) Sidney E. Grossberg et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Effective Treatment of Psoriasis with Narrow-Band UVB Phototherapy Is Linked to Suppression of the IFN and Th17 Pathways

(2011) Emőke Rácz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Accelerated central nervous system autoimmunity in BAFF-receptor-deficient mice

(2011) Susan S. Kim et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis

(2011) Xuan Feng et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Comparison of two dosing frequencies of subcutaneous interferon beta-1a in patients with a first clinical demyelinating event suggestive of multiple sclerosis (REFLEX): a phase 3 randomised controlled trial

(2011) Giancarlo Comi et al.   LANCET NEUROLOGY

Predictive factors of neutralizing antibodies development in relapsing-remitting multiple sclerosis patients on interferon Beta-1b therapy

(2011) R. Lanzillo et al.   NEUROLOGICAL SCIENCES

Interferon  -1b-neutralizing antibodies 5 years after clinically isolated syndrome

(2011) H.- P. Hartung et al.   NEUROLOGY

Excessive Biologic Response to IFNβ Is Associated with Poor Treatment Response in Patients with Multiple Sclerosis

(2011) Richard A. Rudick et al.   PLoS One

IL-7 Promotes TH1 Development and Serum IL-7 Predicts Clinical Response to Interferon-  in Multiple Sclerosis

(2011) L.-F. Lee et al.   Science Translational Medicine

BAFF and selection of autoreactive B cells

(2011) Zheng Liu et al.   TRENDS IN IMMUNOLOGY

Emerging cellular networks for regulation of T follicular helper cells

(2011) Cecile King et al.   TRENDS IN IMMUNOLOGY

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

(2011) Deborah S. Cunninghame Graham et al.   PLoS Genetics

Involvement of IL-17F via the induction of IL-6 in psoriasis

(2010) Sawa Fujishima et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Interferon Beta Treatment in Neuromyelitis Optica

(2010) Jacqueline Palace et al.   ARCHIVES OF NEUROLOGY

Interferon-α accelerates murine systemic lupus erythematosus in a T cell-dependent manner

(2010) Zheng Liu et al.   ARTHRITIS AND RHEUMATISM

Tocilizumab in systemic lupus erythematosus: Data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study

(2010) Gabor G. Illei et al.   ARTHRITIS AND RHEUMATISM

Association of a functional IRF7 variant with systemic lupus erythematosus

(2010) Qiong Fu et al.   ARTHRITIS AND RHEUMATISM

Time course transcriptomics of IFNB1b drug therapy in multiple sclerosis

(2010) P. Serrano-Fernández et al.   AUTOIMMUNITY

Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy

(2010) S. Coimbra et al.   BRITISH JOURNAL OF DERMATOLOGY

Interleukin-7 Permits Th1/Tc1 Maturation and Promotes Ex vivo Expansion of Cord Blood T Cells: A Critical Step toward Adoptive Immunotherapy after Cord Blood Transplantation

(2010) C. C. Davis et al.   CANCER RESEARCH

Pegylated Interferons for the Treatment of Chronic Hepatitis C

(2010) Graham R. Foster   DRUGS

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

(2010) Johanna K Sandling et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Suppression of inflammation in ulcerative colitis by interferon- -1a is accompanied by inhibition of IL-13 production

(2010) P. J. Mannon et al.   GUT

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Enhanced IL-6 Production in Aquaporin-4 Antibody Positive Neuromyelitis Optica Patients

(2010) Sema İİçöz et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Cutting Edge: Novel Function of B Cell-Activating Factor in the Induction of IL-10-Producing Regulatory B Cells

(2010) M. Yang et al.   JOURNAL OF IMMUNOLOGY

IL-17 Activates the Canonical NF-κB Signaling Pathway in Autoimmune B Cells of BXD2 Mice To Upregulate the Expression of Regulators of G-Protein Signaling 16

(2010) Shutao Xie et al.   JOURNAL OF IMMUNOLOGY

One-year evaluation of factors affecting the biological activity of interferon beta in multiple sclerosis patients

(2010) Simona Malucchi et al.   JOURNAL OF NEUROLOGY

Preferential increase of B-cell activating factor in the cerebrospinal fluid of neuromyelitis optica in a white population

(2010) Adi Vaknin-Dembinsky et al.   Multiple Sclerosis Journal

Interferon-β is a key regulator of proinflammatory events in experimental autoimmune encephalomyelitis

(2010) CL Galligan et al.   Multiple Sclerosis Journal

High-dose frequency beta-interferons increase the risk of liver test abnormalities in multiple sclerosis: a longitudinal study

(2010) S Chan et al.   Multiple Sclerosis Journal

Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease

(2010) Xuebin Liu et al.   NATURE MEDICINE

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

IFN -1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum

(2010) J. Shimizu et al.   NEUROLOGY

Effector and Regulatory T-cell Subsets in Autoimmunity and Tissue Inflammation

(2010) A. Jäger et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS

(2010) Marco Prinz et al.   TRENDS IN MOLECULAR MEDICINE

Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

(2010) Kamini Shah et al.   ARTHRITIS RESEARCH & THERAPY

Atacicept: targeting B cells in multiple sclerosis

(2010) Hans-Peter Hartung et al.   Therapeutic Advances in Neurological Disorders

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β

(2009) Luca Durelli et al.   ANNALS OF NEUROLOGY

Heterogeneous, Longitudinally Stable Molecular Signatures in Response to Interferon-β

(2009) M. R. Sandhya Rani et al.   Annals of the New York Academy of Sciences

Neutralization of interferon-α/β-inducible genes and downstream effect in a phase I trial of an anti-interferon-α monoclonal antibody in systemic lupus erythematosus

(2009) Yihong Yao et al.   ARTHRITIS AND RHEUMATISM

Interferon-α treatment of female (NZW × BXSB)F1mice mimics some but not all features associated with theYaamutation

(2009) Meera Ramanujam et al.   ARTHRITIS AND RHEUMATISM

Does Epstein-Barr virus infection in the brain drive the development of multiple sclerosis?

(2009) M. P. Pender   BRAIN

A type I interferon signature in monocytes is associated with poor response to interferon-β in multiple sclerosis

(2009) M. Comabella et al.   BRAIN

New-onset psoriasis in a patient treated with interferon beta-1a

(2009) I. López-Lerma et al.   BRITISH JOURNAL OF DERMATOLOGY

Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice

(2009) Zili Zhang et al.   CYTOKINE

IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytesviaincreased IL-22 receptor expression

(2009) Mikiko Tohyama et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Different responses to interferon beta-1b treatment in patients with neuromyelitis optica and multiple sclerosis

(2009) A. Uzawa et al.   EUROPEAN JOURNAL OF NEUROLOGY

IFN-  Inhibits Human Th17 Cell Differentiation

(2009) V. S. Ramgolam et al.   JOURNAL OF IMMUNOLOGY

Anti-Inflammatory Role of IL-17 in Experimental Autoimmune Uveitis

(2009) Y. Ke et al.   JOURNAL OF IMMUNOLOGY

Psoriasis during interferon beta treatment for multiple sclerosis

(2009) Loredana La Mantia et al.   NEUROLOGICAL SCIENCES

Heterogeneity of human effector CD4+ T cells

(2009) Francesco Annunziato et al.   ARTHRITIS RESEARCH & THERAPY

Clinical trial: a multicentre, randomized, double-blind, placebo-controlled, dose-finding, phase II study of subcutaneous interferon-β-1a in moderately active ulcerative colitis

(2008) C. PENA-ROSSI et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Recent Advances in the Genetics of Autoimmune Disease

(2008) Peter K. Gregersen et al.   Annual Review of Immunology

Neuromyelitis Optica and Non–Organ-Specific Autoimmunity

(2008) Sean J. Pittock et al.   ARCHIVES OF NEUROLOGY

Interferon-β increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity

(2008) M. Krumbholz et al.   BRAIN

Determination of interferon beta neutralizing antibodies in multiple sclerosis: Improvement of clinical sensitivity of a cytopathic effect assay

(2008) Catherine Massart et al.   CLINICA CHIMICA ACTA

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

(2008) Beichu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition

(2008) Mark A. Kroenke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Polymorphisms of the IL12B and IL23R Genes Are Associated with Psoriasis

(2008) Rajan P. Nair et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY

Beta interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells

(2008) Francisco M. Martín-Saavedra et al.   MOLECULAR IMMUNOLOGY

Neuromyelitis optica spectrum disorder in a patient with systemic lupus erythematosus and anti-phospholipid antibody syndrome

(2008) Lahar R Mehta et al.   Multiple Sclerosis Journal

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

(2008) Ingunn M Stromnes et al.   NATURE MEDICINE

Type I Interferon: Potential Therapeutic Target for Psoriasis?

(2008) Yihong Yao et al.   PLoS One

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY