The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds
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Title
The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds
Authors
Keywords
Kinase inhibitors, Phosphorylation, Apoptosis, Breast cancer, In vitro kinase assay, Small molecules, Thermal stability, Cell growth
Journal
PLoS One
Volume 9, Issue 11, Pages e113300
Publisher
Public Library of Science (PLoS)
Online
2014-11-21
DOI
10.1371/journal.pone.0113300
References
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Note: Only part of the references are listed.- Cdc7-Dbf4 Kinase Overexpression in Multiple Cancers and Tumor Cell Lines Is Correlated with p53 Inactivation
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- (2013) An Ning Cheng et al. CANCER LETTERS
- ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress
- (2013) M. Yamada et al. GENES & DEVELOPMENT
- Dbf4 and Cdc7 Proteins Promote DNA Replication through Interactions with Distinct Mcm2–7 Protein Subunits
- (2013) Matthew D. Ramer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of huCdc7 in colorectal cancer
- (2013) Hai-Jun Chen WORLD JOURNAL OF GASTROENTEROLOGY
- Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models
- (2013) Alessandro Natoni et al. Cancers
- The design, synthesis, and biological evaluation of PIM kinase inhibitors
- (2012) Amy Lew Tsuhako et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of XL413, a potent and selective CDC7 inhibitor
- (2012) Elena S. Koltun et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Effects of CDC7 gene silencing and Rituximab on apoptosis in diffuse large B cell lymphoma cells
- (2012) Yun Hou et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- High expression of cell division cycle 7 protein correlates with poor prognosis in patients with diffuse large B-cell lymphoma
- (2012) Yun Hou et al. MEDICAL ONCOLOGY
- Crystal structure of human CDC7 kinase in complex with its activator DBF4
- (2012) Siobhan Hughes et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanism of Cancer Cell Death Induced by Depletion of an Essential Replication Regulator
- (2012) Sayuri Ito et al. PLoS One
- Molecular Mechanism of Activation of Human Cdc7 Kinase
- (2011) Ryo Kitamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells
- (2011) A. Natoni et al. MOLECULAR CANCER THERAPEUTICS
- Physiological Relevance of Cell Cycle Kinases
- (2011) Marcos Malumbres PHYSIOLOGICAL REVIEWS
- Probing the Probes: Fitness Factors For Small Molecule Tools
- (2010) Paul Workman et al. CHEMISTRY & BIOLOGY
- Targeting Cell Division Cycle 7 Kinase: A New Approach for Cancer Therapy
- (2010) A. Montagnoli et al. CLINICAL CANCER RESEARCH
- Molecular architecture of the DNA replication origin activation checkpoint
- (2010) Slavica Tudzarova et al. EMBO JOURNAL
- How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?
- (2010) K. Labib GENES & DEVELOPMENT
- Phosphorylated Rad18 directs DNA Polymerase η to sites of stalled replication
- (2010) Tovah A. Day et al. JOURNAL OF CELL BIOLOGY
- Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding
- (2010) Maria Menichincheri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cdc7 Kinase Is a Predictor of Survival and a Novel Therapeutic Target in Epithelial Ovarian Carcinoma
- (2009) A. A. Kulkarni et al. CLINICAL CANCER RESEARCH
- Budding Yeast Dbf4 Sequences Required for Cdc7 Kinase Activation and Identification of a Functional Relationship Between the Dbf4 and Rev1 BRCT Domains
- (2009) Victoria Harkins et al. GENETICS
- Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer
- (2009) Matthias Choschzick et al. HUMAN PATHOLOGY
- Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships
- (2009) Antonella Ermoli et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors
- (2008) Chunlin Zhao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Dbf4-Dependent Cdc7 Kinase Links DNA Replication to the Segregation of Homologous Chromosomes in Meiosis I
- (2008) Joao Matos et al. CELL
- Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts
- (2008) T. S. Takahashi et al. GENES & DEVELOPMENT
- Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination
- (2008) H. Sasanuma et al. GENES & DEVELOPMENT
- Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast
- (2008) L. Wan et al. GENES & DEVELOPMENT
- ATR-dependent Activation of p38 MAP Kinase Is Responsible for Apoptotic Cell Death in Cells Depleted of Cdc7
- (2008) Jun-Sub Im et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships
- (2008) Ermes Vanotti et al. JOURNAL OF MEDICINAL CHEMISTRY
- First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery†
- (2008) Maria Menichincheri et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
- (2008) Alessia Montagnoli et al. Nature Chemical Biology
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