Indoxyl Sulfate-Induced Activation of (Pro)renin Receptor Promotes Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells

The Aryl Hydrocarbon Receptor-Activating Effect of Uremic Toxins from Tryptophan Metabolism: A New Concept to Understand Cardiovascular Complications of Chronic Kidney Disease

(2014) Marion Sallée et al.   Toxins

Indoxyl Sulfate Counteracts Endothelial Effects of Erythropoietin Through Suppression of Akt Phosphorylation

(2013) Yelixiati Adelibieke et al.   CIRCULATION JOURNAL

Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway

(2013) Bertrand Gondouin et al.   KIDNEY INTERNATIONAL

Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats

(2013) Maimaiti Yisireyili et al.   LIFE SCIENCES

Stat3 Contributes to Indoxyl Sulfate-Induced Inflammatory and Fibrotic Gene Expression and Cellular Senescence

(2012) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress

(2012) Gulinuer Muteliefu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Chemotactic effect of prorenin on human aortic smooth muscle cells: a novel function of the (pro)renin receptor

(2012) Carolina M. Greco et al.   CARDIOVASCULAR RESEARCH

Uremic Serum and Solutes Increase Post–Vascular Interventional Thrombotic Risk Through Altered Stability of Smooth Muscle Cell Tissue Factor

(2012) Vipul C. Chitalia et al.   CIRCULATION

Activation of Aryl Hydrocarbon Receptor Mediates Indoxyl Sulfate-Induced Monocyte Chemoattractant Protein-1 Expression in Human Umbilical Vein Endothelial Cells

(2012) Ippei Watanabe et al.   CIRCULATION JOURNAL

Cardiorenal Syndrome

(2012) Suree Lekawanvijit et al.   CIRCULATION RESEARCH

Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells

(2012) Hidehisa Shimizu et al.   LIFE SCIENCES

Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells

(2012) Hidehisa Shimizu et al.   LIFE SCIENCES

NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells

(2011) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Renin- and Prorenin-Induced Effects in Rat Vascular Smooth Muscle Cells Overexpressing the Human (Pro)Renin Receptor

(2011) Wendy W. Batenburg et al.   HYPERTENSION

Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via epidermal growth factor receptor-mediated extracellular signal-regulated kinase and Akt activation pathway

(2011) Gang Liu et al.   JOURNAL OF HYPERTENSION

Indoxyl Sulfate Reduces Klotho Expression and Promotes Senescence in the Kidneys of Hypertensive Rats

(2011) Ayinuer Adijiang et al.   JOURNAL OF RENAL NUTRITION

AST-120 Ameliorates Epithelial-to-Mesenchymal Transition and Interstitial Fibrosis in the Kidneys of Chronic Kidney Disease Rats

(2011) Dilinaer Bolati et al.   JOURNAL OF RENAL NUTRITION

Prorenin Receptor Is Essential for Normal Podocyte Structure and Function

(2011) Y. Oshima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prorenin Receptor Is Essential for Podocyte Autophagy and Survival

(2011) F. Riediger et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of Indoxyl Sulfate in the Progression of Chronic Kidney Disease and Cardiovascular Disease: Experimental and Clinical Effects of Oral Sorbent AST-120

(2011) Toshimitsu Niwa   THERAPEUTIC APHERESIS AND DIALYSIS

Indoxyl Sulfate Upregulates Expression of ICAM-1 and MCP-1 by Oxidative Stress-Induced NF-ĸB Activation

(2010) Zohra Tumur et al.   AMERICAN JOURNAL OF NEPHROLOGY

Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate

(2010) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H + -ATPase Assembly in Murine Cardiomyocytes

(2010) Kenichiro Kinouchi et al.   CIRCULATION RESEARCH

Indoxyl Sulfate Is a Nephro-Vascular Toxin

(2010) Toshimitsu Niwa   JOURNAL OF RENAL NUTRITION

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

(2009) Jennifer C. Schroeder et al.   BIOCHEMISTRY

Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

(2009) F. C. Barreto et al.   Clinical Journal of the American Society of Nephrology

Indoxyl Sulfate Promotes Proliferation of Human Aortic Smooth Muscle Cells by Inducing Oxidative Stress

(2009) Gulinuer Muteliefu et al.   JOURNAL OF RENAL NUTRITION

The Biology of the (Pro)Renin Receptor

(2009) G. Nguyen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Indoxyl sulphate induces oxidative stress and the expression of osteoblast-specific proteins in vascular smooth muscle cells

(2009) G. Muteliefu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Renal (pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1receptor and NADPH oxidase activity

(2008) Helmy M. Siragy et al.   EXPERIMENTAL PHYSIOLOGY

Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats

(2008) A. Adijiang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION