Review
Cardiac & Cardiovascular Systems
Stefan Frantz, Moritz Jens Hundertmark, Jeanette Schulz-Menger, Frank Michael Bengel, Johann Bauersachs
Summary: Most patients survive acute myocardial infarction, but the prevalence of heart failure is increasing, leading to economic strain on healthcare systems. Pathological changes in the heart significantly impact patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, and female sex can distinctively shape the progression towards heart failure.
EUROPEAN HEART JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
John A. D'Elia, George P. Bayliss, Larry A. Weinrauch
Summary: Cardiorenal syndrome, the end-stage of heart failure and kidney disease combination, is a serious condition that is influenced by factors such as diabetes, hyperlipidemia, obesity, hypertension, and renal impairment. Current therapy focuses on improving hemodynamic factors destructive to both the heart and kidney, but there have been limited advances in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Hematology
David Schumacher, Rafael Kramann
Summary: Lack of targeted therapies for cardiac remodeling and fibrosis results in high long-term morbidity and mortality after myocardial infarction.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Valero-Munoz, Albin Oh, Elizabeth Faudoa, Rosa Breton-Romero, Fatima El Adili, Andreea Bujor, Flora Sam
Summary: This study identified significant evidence of endothelial-mesenchymal transition (endo-MT) in both mice and human endothelial cells with HFpEF and the cardiorenal syndrome, highlighting potential therapeutic implications for drug development in HFpEF patients with concomitant renal dysfunction.
CIRCULATION-HEART FAILURE
(2021)
Review
Medicine, Research & Experimental
Xiaoguang Wu, Yi Li, Shuchen Zhang, Xiang Zhou
Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.
Article
Nanoscience & Nanotechnology
Hailing Chen, Lu Fan, Ningxin Peng, Yong Yin, Dan Mu, Jun Wang, Ran Meng, Jun Xie
Summary: This study developed a biocompatible microneedle patch loaded with galunisertib to inhibit excessive fibrosis after myocardial infarction (MI), resulting in improved cardiac function and reduced fibrosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Cardiac & Cardiovascular Systems
Yuting Guo, Wei Zhang, Xinger Zhou, Shihao Zhao, Jian Wang, Yi Guo, Yichao Liao, Haihui Lu, Jie Liu, Yanbin Cai, Jiao Wu, Mingzhi Shen
Summary: Ferroptosis, an iron-dependent regulated cell death, has been shown to be closely related to various cardiovascular diseases. This article reviews the contributions of ferroptosis to cardiovascular diseases and discusses potential strategies for treating these diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Eleni Petra, Tianlin He, Vasiliki Lygirou, Agnieszka Latosinska, Harald Mischak, Antonia Vlahou, Joachim Jankowski
Summary: This study identified 559 differentially excreted urinary peptides associated with CRS patients, with 193 peptides specifically found in CRS. Proteasix predicted 18 proteases involved in CRS-associated peptide generation, and pathway enrichment analysis supported ECM-related pathways, fibrosis, and inflammation as key elements in CRS pathophysiology.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Beatriz Delgado-Valero, Victoria Cachofeiro, Ernesto Martinez-Martinez
Summary: Cardiorenal syndrome describes the complex interaction between heart and kidney disease, with renal dysfunction posing a significant threat to cardiac patients. Fibrosis is a key factor in the progression of organ injury and is believed to play a crucial role in the pathophysiology of cardiorenal syndromes.
Article
Cardiac & Cardiovascular Systems
Amil. M. M. Shah, Brian Claggett, Narayana Prasad, Guichu Li, Mayra Volquez, Karola Jering, Maja Cikes, Attila Kovacs, Wilfried Mullens, Jose C. Nicolau, Lars Kober, Peter Van der Meer, Pardeep. S. S. Jhund, Ghionul Ibram, Martin Lefkowitz, Yinong Zhou, Scott. D. D. Solomon, Marc A. Pfeffer
Summary: This study compared the effects of sacubitril/valsartan and ramipril on left ventricular function and adverse remodeling after acute myocardial infarction (AMI). The results showed that patients randomized to sacubitril/valsartan had better improvements in filling pressure, left ventricular volume changes, and other aspects compared to those randomized to ramipril.
Review
Biochemistry & Molecular Biology
Piotr Lagosz, Jan Biegus, Szymon Urban, Robert Zymlinski
Summary: Cardiorenal syndrome (CRS) is a complex and heterogeneous spectrum of symptoms that has posed challenges for cardiologists for many years. The coexistence of heart failure (HF) and deteriorated renal function adds to these challenges and is a strong predictor of poor outcomes. However, with the development of new renal assessment methods, we now have the opportunity to treat CRS more effectively than ever before. This review focuses on explaining the pathophysiology, recent advances, and current practices of monitoring renal function in patients with acute CRS, aiming to improve patient care and guide treatment strategies.
Review
Urology & Nephrology
Ana Belen Mendez, Maria Antonieta Azancot, Aleix Olivella, Maria Jose Soler
Summary: Cardiorenal syndrome is a complex disease affecting the heart and kidneys simultaneously. Diagnostic tools include biomarkers, pulmonary ultrasound, monitoring of inferior vena cava size, and studying renal venous patterns. New drugs offer potential therapeutic strategies for treating this disease. Multidisciplinary teamwork can also reduce patient visits and hospitalizations.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Immunology
Wei Wu, Li Yan, Xiao-Fei Yuan, Lu Wang, Yu Zhang, Rong-xiang Tu, Jiang-Qi Pan, Lu Yin, Zhi-Ru Ge
Summary: This study identified key hub genes associated with the development of myocardial infarction in diabetics through transcriptome analysis, and explored the functional roles of these genes. The results suggest that these hub genes may become novel biomarkers for prognosis and precision treatment in myocardial infarction with diabetes in the future.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Giovanni Goffredo, Roberta Barone, Vito Di Terlizzi, Michele Correale, Natale Daniele Brunetti, Massimo Iacoviello
Summary: Cardiorenal syndrome is a clinical manifestation of the bidirectional interaction between heart and kidney diseases. Multiple biomarkers have been studied over recent years to better assess renal function and identify patients at risk of chronic or acute worsening of kidney function. This review aims to discuss the potential clinical utility of the latest biomarkers in the context of cardiorenal syndrome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Zhi-Teng Chen, Qing-Yuan Gao, Mao-Xiong Wu, Meng Wang, Run-Lu Sun, Yuan Jiang, Qi Guo, Da-Chuan Guo, Chi-Yu Liu, Si-Xu Chen, Xiao Liu, Jing-Feng Wang, Hai-Feng Zhang, Yang-Xin Chen
Summary: The study demonstrated the significant role of glycolysis in cardiac fibrosis post-myocardial infarction, with glycolysis inhibition showing potential in reducing cardiac fibroblast activation and fibrosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew R. Kompa, David W. Greening, Anne M. Kong, Paul J. McMillan, Haoyun Fang, Ritika Saxena, Raymond C. B. Wong, Jarmon G. Lees, Priyadharshini Sivakumaran, Andrew E. Newcomb, Bakhos A. Tannous, Cameron Kos, Lina Mariana, Thomas Loudovaris, Derek J. Hausenloy, Shiang Y. Lim
Summary: Subcutaneous implantation of TheraCyte devices containing the secretome of human cardiac stem cells attenuated adverse cardiac remodelling and preserved cardiac function following myocardial infarction. The secretome-based therapy led to reduced fibrosis, increased myocardial vascular density, and improved cardiac function.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Feby Savira, Bing H. Wang, Andrew R. Kompa, Zanfina Ademi, Alice J. Owen, Sophia Zoungas, Andrew Tonkin, Danny Liew, Ella Zomer
Summary: The study found that adding dapagliflozin as an adjunct therapy to standard care for patients with chronic heart failure and reduced ejection fraction can prevent acute heart failure hospitalizations, increase years of life and quality-adjusted life-years, at a cost-effective ratio well below the Australian willingness-to-pay threshold.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Feby Savira, Amanda J. Edgley, Beat M. Jucker, Robert N. Willette, Henry Krum, Darren J. Kelly, Andrew R. Kompa, Bing H. Wang
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Feby Savira, Andrew R. Kompa, Amanda J. Edgley, Beat M. Jucker, Robert N. Willette, Darren J. Kelly, Bing H. Wang
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
James T. Pearson, Hamish P. Thambyah, Mark T. Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P. Ngo, Connie P. C. Ow, Takashi Sonobe, Yi Ching Chen, Amanda J. Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J. Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai
Summary: A high salt intake exacerbates insulin resistance and induces hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress, and endothelial dysfunction. Treatment with ACE inhibitors and ARBs can alleviate inflammation and redox stress, but only partially restore endothelial function in mesenteric vessels. In male Goto-Kakizaki (GK) and Wistar rats, combination of high salt intake and insulin resistance leads to coronary microvessel endothelial dysfunction, which was restored by CAR and MET treatment, despite ongoing inflammation and oxidative-nitrosative stress.
Article
Medicine, Research & Experimental
Feby Savira, Andrew R. Kompa, Ruth Magaye, Xin Xiong, Li Huang, Beat M. Jucker, Robert N. Willette, Darren J. Kelly, Bing H. Wang
Summary: The study showed that Indoxyl sulfate (IS) impairs endothelium-dependent vasorelaxation and endothelial cell migration, while inhibition of apoptosis signal regulating kinase 1 (ASK1) can alleviate these effects and promote autocrine interleukin 8 (IL-8) pro-angiogenic signaling.
Article
Medicine, Research & Experimental
Andrew R. Kompa, Fay L. Khong, Yuan Zhang, Cindy Nguyen, Amanda J. Edgley, Owen L. Woodman, Grant McLachlan, Darren J. Kelly
Summary: This study evaluated the efficacy of NP202, a synthetic flavonol, on cardiac remodelling in a chronic model of myocardial infarction (MI). Results showed that NP202 improved left ventricular function and structure, especially at a higher dose. NP202 also reduced hypertrophy and interstitial fibrosis in the non-infarct region of the myocardium.
Article
Toxicology
Feby Savira, Ruth Magaye, Carmen Scullino, Bernard L. Flynn, Stuart M. Pitson, Dovile Anderson, Darren J. Creek, Yue Hua, Xin Xiong, Li Huang, Danny Liew, Christopher Reid, David Kaye, Andrew R. Kompa, Bing Hui Wang
Summary: This study assessed the effects of Des1 inhibition on PBUT-induced cardiac and renal effects, showing that Des1 inhibition attenuated negative effects on heart and kidney cells induced by PBUTs, such as hypertrophy and collagen synthesis, by modulating NF-κB signaling and reducing gene expression levels.
TOXICOLOGY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Feby Savira, Andrew R. Kompa, Darren J. Kelly, Ruth Magaye, Xin Xiong, Li Huang, Danny Liew, Christopher Reid, David Kaye, Carmen V. Scullino, Stuart M. Pitson, Bernard L. Flynn, Bing H. Wang
Summary: The study evaluated the therapeutic potential of using a Des1 inhibitor to mitigate the vascular effects caused by PBUT indoxyl sulfate. Inhibition of Des1 improved vascular relaxation and endothelial cell migration impaired by IS overload, suggesting that Des1 may be a suitable intracellular target to counteract the adverse vascular effects induced by PBUTs.
VASCULAR PHARMACOLOGY
(2021)
Article
Food Science & Technology
Cindy Nguyen, Amanda J. Edgley, Darren J. Kelly, Andrew R. Kompa
Summary: This study investigates the effects of the uremic toxin indoxyl sulfate (IS) on vascular endothelial function and redox balance. The results indicate that IS impairs endothelium-dependent relaxation and increases the expression of oxidative stress markers. Inhibition of the aryl hydrocarbon receptor (AhR) could be a potential therapy for cardiovascular disease in the context of chronic kidney disease (CKD).
Review
Pharmacology & Pharmacy
Bui San Thai, Ling Yeong Chia, Anh T. N. Nguyen, Chengxue Qin, Rebecca H. Ritchie, Dana S. Hutchinson, Andrew Kompa, Paul J. White, Lauren T. May
Summary: Heart failure remains a significant cause of morbidity and mortality worldwide. Current treatment options have limitations, leading to many patients progressing to advanced stages. Exploration of novel therapeutics targeting G protein-coupled receptors (GPCRs) has shown promise, but efficacy and unwanted effects remain as challenges.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Feby Savira, Bing H. Wang, Andrew R. Kompa, Zanfina Ademi, Alice J. Owen, Danny Liew, Ella Zomer
Summary: This study aimed to determine the impact of preventing new cases of coronary heart disease on years of life and productivity over the next 10 years, using the novel measure PALY. The model predicted total years lived, PALYs, GDP, and potential benefits of preventing CHD in the Australian working-age population.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)