Hinokitiol Induces DNA Damage and Autophagy followed by Cell Cycle Arrest and Senescence in Gefitinib-Resistant Lung Adenocarcinoma Cells

In Vitro and in Vivo Therapeutics of β-Thujaplicin on Lps-Induced Inflammation in Macrophages and Septic Shock in Mice

(2017) M-F. Shih et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death

(2014) José M. Calderón-Montaño et al.   Pharmacological Reports

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

A regulatory role of K+–Cl− cotransporter in the cell cycle progression of breast cancer MDA-MB-231 cells

(2013) Maki Kitagawa et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inhibiting proliferation of gefitinib-resistant, non-small cell lung cancer

(2013) Makoto Sudo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

KRASMutation: Should We Test for It, and Does It Matter?

(2013) Patrick J. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

Hinokitiol Inhibits Cell Growth through Induction of S-Phase Arrest and Apoptosis in Human Colon Cancer Cells and Suppresses Tumor Growth in a Mouse Xenograft Experiment

(2013) Youn-Sun Lee et al.   JOURNAL OF NATURAL PRODUCTS

In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines

(2013) Yin-Hua Shih et al.   MICROBIOLOGICAL RESEARCH

Uracil-DNA Glycosylase Expression Determines Human Lung Cancer Cell Sensitivity to Pemetrexed

(2013) L. D. Weeks et al.   MOLECULAR CANCER THERAPEUTICS

Nuclear EGFR as a molecular target in cancer

(2013) Toni M. Brand et al.   RADIOTHERAPY AND ONCOLOGY

Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase

(2012) H Hiyoshi et al.   BRITISH JOURNAL OF CANCER

MEK inhibitors reverse resistance in epidermal growth factor receptor mutation lung cancer cells with acquired resistance to gefitinib

(2012) Ming-Hung Huang et al.   Molecular Oncology

An Aqueous Extract of Fagonia cretica Induces DNA Damage, Cell Cycle Arrest and Apoptosis in Breast Cancer Cells via FOXO3a and p53 Expression

(2012) Matt Lam et al.   PLoS One

NVX-412, a New Oncology Drug Candidate, Induces S-Phase Arrest and DNA Damage in Cancer Cells in a p53-Independent Manner

(2012) Alexandra Hebar et al.   PLoS One

An NQO1-Initiated and p53-Independent Apoptotic Pathway Determines the Anti-Tumor Effect of Tanshinone IIA against Non-Small Cell Lung Cancer

(2012) Fang Liu et al.   PLoS One

Vapor of Volatile Oils from Litsea cubeba Seed Induces Apoptosis and Causes Cell Cycle Arrest in Lung Cancer Cells

(2012) Soma Seal et al.   PLoS One

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

(2012) Pierre Caron et al.   PLoS Genetics

NK314 potentiates antitumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase II  and DNA-dependent protein kinase

(2011) T. Hisatomi et al.   BLOOD

Prevention of Bronchial Hyperplasia by EGFR Pathway Inhibitors in an Organotypic Culture Model

(2011) J. Lee et al.   Cancer Prevention Research

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Genomic Profiles Specific to Patient Ethnicity in Lung Adenocarcinoma

(2011) P. Broet et al.   CLINICAL CANCER RESEARCH

Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner

(2011) Yi Luo et al.   EXPERIMENTAL GERONTOLOGY

MKK4 suppresses metastatic colonization by multiple highly metastatic prostate cancer cell lines through a transient impairment in cell cycle progression

(2011) Russell Z. Szmulewitz et al.   INTERNATIONAL JOURNAL OF CANCER

Resveratrol-induced apoptosis is enhanced in low pH environments associated with cancer

(2011) Uzma Shamim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

DNA damage and autophagy

(2011) Humberto Rodriguez-Rocha et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Overexpression and Small Molecule-Triggered Downregulation of CIP2A in Lung Cancer

(2011) Liang Ma et al.   PLoS One

Slug Confers Resistance to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

(2010) Tzu-Hua Chang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sustained exposure to the DNA demethylating agent, 2′-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy

(2010) Michael Schnekenburger et al.   BIOCHEMICAL PHARMACOLOGY

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Everolimus restores gefitinib sensitivity in resistant non-small cell lung cancer cell lines

(2009) Silvia La Monica et al.   BIOCHEMICAL PHARMACOLOGY

Preventive and therapeutic anti-inflammatory properties of the sesquiterpene α-humulene in experimental airways allergic inflammation

(2009) Alexandre P. Rogerio et al.   BRITISH JOURNAL OF PHARMACOLOGY

p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function

(2009) Shicheng Liu et al.   CANCER LETTERS

Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells

(2009) Shu-Jun Chiu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells

(2009) Erwan Watrin et al.   EMBO JOURNAL

Eating to exit: autophagy-enabled senescence revealed

(2009) E. White et al.   GENES & DEVELOPMENT

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

An extract fromRicinus communisL. leaves possesses cytotoxic properties and induces apoptosis in SK-MEL-28 human melanoma cells

(2009) Stephanie Darmanin et al.   NATURAL PRODUCT RESEARCH

Antifungal Mechanism of Hinokitiol against Candida albicans

(2008) Nami Komaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1

(2008) H.-W. Chen et al.   CANCER RESEARCH

Antifungal properties of ethanolic extract and its active compounds from Calocedrus macrolepis var. formosana (Florin) heartwood

(2007) Tsair-Bor Yen et al.   BIORESOURCE TECHNOLOGY