Flaviviral Replication Complex: Coordination between RNA Synthesis and 5’-RNA Capping

Ultrastructure of the replication sites of positive-strand RNA viruses

(2015) Christian Harak et al.   VIROLOGY

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

Substitution of NS5 N-terminal Domain of Dengue Virus Type 2 RNA with Type 4 Domain Caused Impaired Replication and Emergence of Adaptive Mutants with Enhanced Fitness

(2014) Tadahisa Teramoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-terminal 50 Amino Acid Residues of Dengue NS3 Protein Are Important for NS3-NS5 Interaction and Viral Replication

(2014) Moon Y. F. Tay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dimerization of Flavivirus NS4B Protein

(2014) J. Zou et al.   JOURNAL OF VIROLOGY

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

(2014) Supanee Potisopon et al.   NUCLEIC ACIDS RESEARCH

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

(2014) Xiao-Dan Li et al.   PLoS Neglected Tropical Diseases

An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein

(2013) C. S. E. Tan et al.   JOURNAL OF GENERAL VIROLOGY

An N-Terminal Amphipathic Helix in Dengue Virus Nonstructural Protein 4A Mediates Oligomerization and Is Essential for Replication

(2013) O. Stern et al.   JOURNAL OF VIROLOGY

Three-Dimensional Architecture of Tick-Borne Encephalitis Virus Replication Sites and Trafficking of the Replicated RNA

(2013) L. Miorin et al.   JOURNAL OF VIROLOGY

Protein–protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells

(2013) Li Yu et al.   VIROLOGY

Non-structural protein-1 is required for West Nile virus replication complex formation and viral RNA synthesis

(2013) Soonjeon Youn et al.   Virology Journal

Replication Cycle and Molecular Biology of the West Nile Virus

(2013) Margo Brinton   Viruses-Basel

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Establishment of a robust dengue virus NS3–NS5 binding assay for identification of protein–protein interaction inhibitors

(2012) Hirotaka Takahashi et al.   ANTIVIRAL RESEARCH

Dengue Virus Nonstructural Protein 5 Adopts Multiple Conformations in Solution

(2012) Cécile Bussetta et al.   BIOCHEMISTRY

Evidence for a Genetic and Physical Interaction between Nonstructural Proteins NS1 and NS4B That Modulates Replication of West Nile Virus

(2012) S. Youn et al.   JOURNAL OF VIROLOGY

Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Hepatitis C Virus Replication

(2012) Inés Romero-Brey et al.   PLoS Pathogens

Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

(2011) Gang Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoclonal antibodies against dengue NS2B and NS3 proteins for the study of protein interactions in the flaviviral replication complex

(2011) Nicole J. Moreland et al.   JOURNAL OF VIROLOGICAL METHODS

The Endoplasmic Reticulum Provides the Membrane Platform for Biogenesis of the Flavivirus Replication Complex

(2010) Leah K. Gillespie et al.   JOURNAL OF VIROLOGY

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

Analysis of the nucleoside triphosphatase, RNA triphosphatase, and unwinding activities of the helicase domain of dengue virus NS3 protein

(2009) Chun-Chung Wang et al.   FEBS LETTERS

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

(2009) M. Issur et al.   RNA

Genetic Interactions among the West Nile Virus Methyltransferase, the RNA-Dependent RNA Polymerase, and the 5' Stem-Loop of Genomic RNA

(2008) B. Zhang et al.   JOURNAL OF VIROLOGY

Structural and Functional Studies of the Promoter Element for Dengue Virus RNA Replication

(2008) M. F. Lodeiro et al.   JOURNAL OF VIROLOGY

West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

(2008) H. Dong et al.   JOURNAL OF VIROLOGY