Substitution of NS5 N-terminal Domain of Dengue Virus Type 2 RNA with Type 4 Domain Caused Impaired Replication and Emergence of Adaptive Mutants with Enhanced Fitness

Dengue More Prevalent Than Previously Thought

(2013) Mike Mitka   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Establishment of a robust dengue virus NS3–NS5 binding assay for identification of protein–protein interaction inhibitors

(2012) Hirotaka Takahashi et al.   ANTIVIRAL RESEARCH

Structural biology of dengue virus enzymes: Towards rational design of therapeutics

(2012) Christian G. Noble et al.   ANTIVIRAL RESEARCH

Novel ATP-Independent RNA Annealing Activity of the Dengue Virus NS3 Helicase

(2012) Leopoldo G. Gebhard et al.   PLoS One

Innate Immunity Evasion by Dengue Virus

(2012) Juliet Morrison et al.   Viruses-Basel

2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase

(2012) Hongping Dong et al.   PLoS Pathogens

Identification ofCis-Acting Elements in the 3′-Untranslated Region of the Dengue Virus Type 2 RNA That Modulate Translation and Replication

(2011) Mark Manzano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

(2011) Gang Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conventional and unconventional mechanisms for capping viral mRNA

(2011) Etienne Decroly et al.   NATURE REVIEWS MICROBIOLOGY

Flexibility between the Protease and Helicase Domains of the Dengue Virus NS3 Protein Conferred by the Linker Region and Its Functional Implications

(2010) Dahai Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dengue: a continuing global threat

(2010) Maria G. Guzman et al.   NATURE REVIEWS MICROBIOLOGY

Biochemical and genetic characterization of dengue virus methyltransferase

(2010) Hongping Dong et al.   VIROLOGY

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

(2009) M. Issur et al.   RNA

Molecular aspects of Dengue virus replication

(2008) Ralf Bartenschlager et al.   Future Microbiology

Mutagenesis of the Dengue Virus Type 2 NS5 Methyltransferase Domain

(2008) Helga Kroschewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome 3'-end repair in dengue virus type 2

(2008) T. Teramoto et al.   RNA

Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3′ untranslated region (3′-UTR) or by exchange of the DENV-3 3′-UTR with that of DENV-4

(2008) Joseph E. Blaney et al.   VACCINE

Specific requirements for elements of the 5′ and 3′ terminal regions in flavivirus RNA synthesis and viral replication

(2008) Li Yu et al.   VIROLOGY