Systems Biology Approach Reveals Genome to Phenome Correlation in Type 2 Diabetes

Genome-wide Transcriptome Profiling Reveals the Functional Impact of Rare De Novo and Recurrent CNVs in Autism Spectrum Disorders

(2012) Rui Luo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Data-driven integration of epidemiological and toxicological data to select candidate interacting genes and environmental factors in association with disease

(2012) C. J. Patel et al.   BIOINFORMATICS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

(2012) R. Bergholdt et al.   DIABETES

U-statistics in genetic association studies

(2012) Hongzhe Li   HUMAN GENETICS

Cross-talk between Insulin and Wnt Signaling in Preadipocytes

(2012) Jane Palsgaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGF Receptor (ERBB1) Abundance in Adipose Tissue Is Reduced in Insulin-Resistant and Type 2 Diabetic Women

(2012) Carlyle Rogers et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metabolomics in diabetes research

(2012) Nele Friedrich   JOURNAL OF ENDOCRINOLOGY

Asking for more

(2012)   NATURE GENETICS

Leveraging models of cell regulation and GWAS data in integrative network-based association studies

(2012) Andrea Califano et al.   NATURE GENETICS

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

(2012) Alisa K Manning et al.   NATURE GENETICS

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Rare and common variants: twenty arguments

(2012) Greg Gibson   NATURE REVIEWS GENETICS

Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes

(2012) K. Kodama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

(2012) J. A. Tennessen et al.   SCIENCE

Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria

(2011) Dawn K. Coletta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Critical role of the transient activation of p38 MAPK in the etiology of skeletal muscle insulin resistance induced by low-level in vitro oxidant stress

(2011) Maggie K. Diamond-Stanic et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BioGRID REST Service, BiogridPlugin2 and BioGRID WebGraph: new tools for access to interaction data at BioGRID

(2011) Andrew G. Winter et al.   BIOINFORMATICS

Benchmarking of the 2010 BioCreative Challenge III text-mining competition by the BioGRID and MINT interaction databases

(2011) Andrew Chatr-aryamontri et al.   BMC BIOINFORMATICS

Constructing a robust protein-protein interaction network by integrating multiple public databases

(2011) Venkata-Swamy Martha et al.   BMC BIOINFORMATICS

Algal Functional Annotation Tool: a web-based analysis suite to functionally interpret large gene lists using integrated annotation and expression data

(2011) David Lopez et al.   BMC BIOINFORMATICS

Too many breaks (brakes): Pancreatic β-cell senescence leads to diabetes

(2011) Omid Tavana et al.   CELL CYCLE

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

 40 Isoform of p53 Controls  -Cell Proliferation and Glucose Homeostasis in Mice

(2011) C. Hinault et al.   DIABETES

Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet

(2011) C. K. Tan et al.   DIABETES

Immune cells in adipose tissue: Key players in metabolic disorders

(2011) K. Lolmède et al.   DIABETES & METABOLISM

State of the union between metabolism and the immune system in type 2 diabetes

(2011) B S Nikolajczyk et al.   GENES AND IMMUNITY

Prioritizing candidate disease genes by network-based boosting of genome-wide association data

(2011) I. Lee et al.   GENOME RESEARCH

An Early Response Transcription Factor, Egr-1, Enhances Insulin Resistance in Type 2 Diabetes with Chronic Hyperinsulinism

(2011) Ning Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resistance to type 2 diabetes mellitus: a matter of hormesis?

(2011) Hubert Kolb et al.   Nature Reviews Endocrinology

Pericytopathy: Oxidative Stress and Impaired Cellular Longevity in the Pancreas and Skeletal Muscle in Metabolic Syndrome and Type 2 Diabetes

(2011) Melvin R. Hayden et al.   Oxidative Medicine and Cellular Longevity

Molecular genetic studies of complex phenotypes

(2011) Ali J. Marian   Translational Research

Emerging roles of JAK–STAT signaling pathways in adipocytes

(2011) Allison J. Richard et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans

(2011) Maxime Rotival et al.   PLoS Genetics

Integrating Pathway Analysis and Genetics of Gene Expression for Genome-wide Association Studies

(2010) Hua Zhong et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The genetics of type 2 diabetes: what have we learned from GWAS?

(2010) Liana K. Billings et al.   Annals of the New York Academy of Sciences

Genome-Wide Association Studies: Results from the First Few Years and Potential Implications for Clinical Medicine

(2010) Joel N. Hirschhorn et al.   Annual Review of Medicine

Combination of genomic approaches with functional genetic experiments reveals two modes of repression of yeast middle-phase meiosis genes

(2010) Michael Klutstein et al.   BMC GENOMICS

Impact of RNA degradation on gene expression profiling

(2010) Lennart Opitz et al.   BMC Medical Genomics

Role of VEGF-A in Pancreatic Beta Cells

(2010) Hirotaka WATADA   ENDOCRINE JOURNAL

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Getting biological about the genetics of diabetes

(2010) Christopher B Newgard et al.   NATURE MEDICINE

Genomics, Type 2 Diabetes, and Obesity

(2010) Mark I. McCarthy   NEW ENGLAND JOURNAL OF MEDICINE

The Comparative Toxicogenomics Database: update 2011

(2010) A. P. Davis et al.   NUCLEIC ACIDS RESEARCH

The BioGRID Interaction Database: 2011 update

(2010) C. Stark et al.   NUCLEIC ACIDS RESEARCH

Emerging roles for the TGFβ family in pancreatic β-cell homeostasis

(2010) Melissa L. Brown et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Notch signaling in pancreatic endocrine cell and diabetes

(2009) Wook Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach

(2009) J. R.B. Perry et al.   DIABETES

Phosphatidylinositol 3-Kinase/Akt Pathway Targets Acetylation of Smad3 through Smad3/CREB-binding Protein Interaction

(2009) Lassad Oussaief et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming Growth Factor-β/Smad3 Signaling Regulates Insulin Gene Transcription and Pancreatic Islet β-Cell Function

(2009) Huei-Min Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?

(2008) J. C. Florez   DIABETOLOGIA

Metabolic syndrome: from epidemiology to systems biology

(2008) Aldons J. Lusis et al.   NATURE REVIEWS GENETICS

Type 2 diabetes: new genes, new understanding

(2008) Inga Prokopenko et al.   TRENDS IN GENETICS