State of the union between metabolism and the immune system in type 2 diabetes

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

(2014) J. Pene et al.   JOURNAL OF IMMUNOLOGY

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

B cells as under-appreciated mediators of non-auto-immune inflammatory disease

(2010) Barbara S. Nikolajczyk   CYTOKINE

Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

(2010) M. E. Shaul et al.   DIABETES

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Toll-like receptors regulate B cell cytokine production in patients with diabetes

(2010) M. Jagannathan et al.   DIABETOLOGIA

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

(2010) Reiko M. Onishi et al.   IMMUNOLOGY

Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor–specified peripheral niche constraints

(2010) Junko Nishio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diabetes-Induced Oxidative Stress Is Mediated by Ca2+-Independent Phospholipase A2 in Neutrophils

(2010) S. Ayilavarapu et al.   JOURNAL OF IMMUNOLOGY

Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance

(2010) H. Yang et al.   JOURNAL OF IMMUNOLOGY

Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes

(2010) M. Jagannathan-Bogdan et al.   JOURNAL OF IMMUNOLOGY

IL-17 Regulates Adipogenesis, Glucose Homeostasis, and Obesity

(2010) L. A. Zuniga et al.   JOURNAL OF IMMUNOLOGY

T-Cell Recruitment and Th1 Polarization in Adipose Tissue During Diet-Induced Obesity in C57BL/6 Mice

(2010) Katherine J. Strissel et al.   Obesity

Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice

(2010) Toru Hosoi et al.   PLoS One

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

(2010) Y. Ilan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity

(2009) Carine Duffaut et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes

(2009) Jennifer H. Shin et al.   BIOCHEMICAL PHARMACOLOGY

Obesity accelerates thymic aging

(2009) H. Yang et al.   BLOOD

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies

(2009) Omar S Al-Attas et al.   Cardiovascular Diabetology

GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population

(2009) V. M. Lundgren et al.   DIABETES

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes

(2009) G. N. Fredrikson et al.   DIABETOLOGIA

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Obesity predisposes to Th17 bias

(2009) Shawn Winer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel humanized anti-CD3 antibodies induce a predominantly immunoregulatory profile in human peripheral blood mononuclear cells

(2009) Hernandez M. Silva et al.   IMMUNOLOGY LETTERS

Interferon γ Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway

(2009) Fiona C. McGillicuddy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis

(2009) Naim Alkhouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoantibodies in Type 2 Diabetes Induce Stress Fiber Formation and Apoptosis in Endothelial Cells

(2009) Mark B. Zimering et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ICOS Deficiency Results in Exacerbated IL-17 Mediated Experimental Autoimmune Encephalomyelitis

(2009) Georgina Galicia et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Interleukin-6 autoantibodies are involved in the pathogenesis of a subset of type 2 diabetes

(2009) K Fosgerau et al.   JOURNAL OF ENDOCRINOLOGY

The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals

(2009) K. Yanaba et al.   JOURNAL OF IMMUNOLOGY

TLR Cross-Talk Specifically Regulates Cytokine Production by B Cells from Chronic Inflammatory Disease Patients

(2009) M. Jagannathan et al.   JOURNAL OF IMMUNOLOGY

Levels of Serum Interleukin (IL)-6 and Gingival Crevicular Fluid of IL-1β and Prostaglandin E2Among Non-Smoking Subjects With Gingivitis and Type 2 Diabetes

(2009) O.M. Andriankaja et al.   JOURNAL OF PERIODONTOLOGY

Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71

(2009) Yorihiro Nishimura et al.   NATURE MEDICINE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sera from Patients with Type 2 Diabetes Contain Agonistic Autoantibodies Against G Protein-Coupled Receptors

(2009) P. Hempel et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects

(2008) Caroline M. Apovian et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of interleukin-1 and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays

(2008) Jolanta Jura et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia

(2008) M. E. Stegenga et al.   BLOOD

IL-12 serum levels in patients with type 2 diabetes treated with sulphonylureas

(2008) Małgorzata Wegner et al.   CYTOKINE

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity

(2008) O. Osborn et al.   CYTOKINE

Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans

(2008) M. E. Stegenga et al.   DIABETIC MEDICINE

Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice

(2008) K. R. Coenen et al.   DIABETOLOGIA

The Antiinflammatory Cytokine Interleukin-1 Receptor Antagonist Protects from High-Fat Diet-Induced Hyperglycemia

(2008) Nadine S. Sauter et al.   ENDOCRINOLOGY

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

Defects in Innate Immunity Predispose C57BL/6J-Leprdb/Leprdb Mice to Infection by Staphylococcus aureus

(2008) S. Park et al.   INFECTION AND IMMUNITY

Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase

(2008) Kazuhiro Omori et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE