Resistance to type 2 diabetes mellitus: a matter of hormesis?

Sensing of energy and nutrients by AMP-activated protein kinase

(2011) D Grahame Hardie   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

(2011) Jun Wu et al.   Cell Metabolism

ER stress and hormetic regulation of the aging process

(2010) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis

(2010) Wei Bao et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The Association Between the Peroxisome Proliferator-Activated Receptor-γ2 (PPARG2) Pro12Ala Gene Variant and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis

(2010) Hebe N. Gouda et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin-sensitive obesity

(2010) Nora Klöting et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors

(2010) Mohan R. Dasu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice

(2010) Mathieu Latreille et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impaired Redox Signaling and Antioxidant Gene Expression in Endothelial Cells in Diabetes: A Role for Mitochondria and the Nuclear Factor-E2-Related Factor 2-Kelch-Like ECH-Associated Protein 1 Defense Pathway

(2010) Xinghua Cheng et al.   ANTIOXIDANTS & REDOX SIGNALING

Nutrient Modification of the Innate Immune Response

(2010) Eric A. Schwartz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The obese healthy paradox: is inflammation the answer?

(2010) Nuria Barbarroja et al.   BIOCHEMICAL JOURNAL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis

(2010) Sabine D. Jordan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

Genetics of type 2 diabetes

(2010) Galina Smushkin et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits

(2010) N Maneka G De Silva et al.   CURRENT OPINION IN LIPIDOLOGY

High interleukin-12 production from stimulated peripheral blood mononuclear cells of type 2 diabetes patients

(2010) Huang-Pin Wu et al.   CYTOKINE

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Prevalence, Metabolic Features, and Prognosis of Metabolically Healthy Obese Italian Individuals: The Cremona Study

(2010) G. Calori et al.   DIABETES CARE

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals

(2010) E. Phielix et al.   DIABETOLOGIA

Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice

(2010) Z. Yu et al.   DIABETOLOGIA

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

(2010) Joshua P. Thaler et al.   ENDOCRINOLOGY

Metabolically healthy obesity: different prevalences using different criteria

(2010) S Velho et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Type 2 Diabetes and Lipoprotein Metabolism Affect LPS-Induced Cytokine and Chemokine Release in Primary Human Monocytes

(2010) M. Bala et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Characterizing the profile of obese patients who are metabolically healthy

(2010) V Primeau et al.   INTERNATIONAL JOURNAL OF OBESITY

Preconditioning with Endoplasmic Reticulum Stress Mitigates Retinal Endothelial Inflammation via Activation of X-box Binding Protein 1

(2010) Jingming Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism

(2010) Laurène Vetterli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current Status of Islet Cell Replacement and Regeneration Therapy

(2010) Philippe A. Halban et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of TLR4-Induced I B Kinase Activity by the RON Receptor Tyrosine Kinase and Its Ligand, Macrophage-Stimulating Protein

(2010) M. Ray et al.   JOURNAL OF IMMUNOLOGY

Elevated endotoxin levels in non-alcoholic fatty liver disease

(2010) Alison L Harte et al.   Journal of Inflammation-London

Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction

(2010) Asli F. Ceylan-Isik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Antioxidant Supplementation Reduces Skeletal Muscle Mitochondrial Biogenesis

(2010) NATALIE A. STROBEL et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

The effect of rowing on endothelial function and insulin action in healthy controls and in patients with type 2 diabetes

(2010) D. B. Olsen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

ER Stress in Pancreatic   Cells: The Thin Red Line Between Adaptation and Failure

(2010) D. L. Eizirik et al.   Science Signaling

Beta cell regeneration in human pancreas

(2010) Roberto Gianani   Seminars in Immunopathology

‘Giving and taking’: endothelial and β-cells in the islets of Langerhans

(2010) Daniel Eberhard et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sirtuin-1 regulation of mammalian metabolism

(2010) Matthew P. Gillum et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

Mild thermotolerance induced at 40°C increases antioxidants and protects HeLa cells against mitochondrial apoptosis induced by hydrogen peroxide: Role of p53

(2009) Pragathi Pallepati et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Different Effects of FK506, Rapamycin, and Mycophenolate Mofetil on Glucose-Stimulated Insulin Release and Apoptosis in Human Islets

(2009) James D. Johnson et al.   CELL TRANSPLANTATION

Successful Versus Failed Adaptation to High-Fat Diet-Induced Insulin Resistance: The Role of IAPP-Induced  -Cell Endoplasmic Reticulum Stress

(2009) A. V. Matveyenko et al.   DIABETES

Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance

(2009) R. Ye et al.   DIABETES

SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity

(2009) M.Carola Zillikens et al.   DIABETES

C. elegans as Model for the Study of High Glucose- Mediated Life Span Reduction

(2009) A. Schlotterer et al.   DIABETES

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

(2009) Daniel A. Cunha et al.   DIABETES

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

Subjects With Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1 /Mitofusin-2 Regulatory Pathway in Response to Physical Activity

(2009) M. I. Hernandez-Alvarez et al.   DIABETES CARE

The effects of glucagon-like peptide-1 on the beta cell

(2009) T. Vilsbøll   DIABETES OBESITY & METABOLISM

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

(2009) H. Kolb et al.   DIABETOLOGIA

Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study

(2009) S W van den Berg et al.   INTERNATIONAL JOURNAL OF OBESITY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Adiponectin Promotes Endotoxin Tolerance in Macrophages by Inducing IRAK-M Expression

(2009) Vassiliki Zacharioudaki et al.   JOURNAL OF IMMUNOLOGY

A Subcytotoxic Dose of Subtilase Cytotoxin Prevents Lipopolysaccharide-Induced Inflammatory Responses, Depending on its Capacity to Induce the Unfolded Protein Response

(2009) D. Harama et al.   JOURNAL OF IMMUNOLOGY

Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-β-dependent pathways and increases expression of negative regulators of TLR signaling

(2009) Wenji Piao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study

(2009)   LANCET

Improved Insulin Sensitivity After Exercise: Focus on Insulin Signaling

(2009) Christian Frøsig et al.   Obesity

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extremely short duration high intensity interval training substantially improves insulin action in young healthy males

(2009) John A Babraj et al.   BMC Endocrine Disorders

SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention – the TULIP Study

(2008) Peter Weyrich et al.   BMC Medical Genetics

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation

(2008) M. R. Dasu et al.   DIABETES

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Heat Treatment Improves Glucose Tolerance and Prevents Skeletal Muscle Insulin Resistance in Rats Fed a High-Fat Diet

(2008) A. A. Gupte et al.   DIABETES

Relationship between β-cell mass and diabetes onset

(2008) A. V. Matveyenko et al.   DIABETES OBESITY & METABOLISM

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

Obesity and Free Fatty Acids

(2008) Guenther Boden   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Association of SIRT1 gene variation with visceral obesity

(2008) Armand V. Peeters et al.   HUMAN GENETICS

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY

Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity

(2008) Andreas Schaeffler et al.   IMMUNOLOGY

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells

(2008) Rafael Herling Lambertucci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study

(2008) Guangwei Li et al.   LANCET

High-fat, energy-dense, fast-food–style breakfast results in an increase in oxidative stress in metabolic syndrome

(2008) Sridevi Devaraj et al.   METABOLISM-CLINICAL AND EXPERIMENTAL