Blood vessel formation and function in bone

Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair

(2016) Kai Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct bone marrow blood vessels differentially regulate haematopoiesis

(2016) Tomer Itkin et al.   NATURE

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Age-dependent modulation of vascular niches for haematopoietic stem cells

(2016) Anjali P. Kusumbe et al.   NATURE

BMP signalling in skeletal development, disease and repair

(2016) Valerie S. Salazar et al.   Nature Reviews Endocrinology

Bringing new life to damaged bone: The importance of angiogenesis in bone repair and regeneration

(2015) Steve Stegen et al.   BONE

Molecular Controls of Arterial Morphogenesis

(2015) M. Simons et al.   CIRCULATION RESEARCH

Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development

(2015) X. Duan et al.   DEVELOPMENT

A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

(2015) E. Kozhemyakina et al.   DEVELOPMENT

c-Raf promotes angiogenesis during normal growth plate maturation

(2015) Eva S. Liu et al.   DEVELOPMENT

Fibroblast growth factor signaling in skeletal development and disease

(2015) David M. Ornitz et al.   GENES & DEVELOPMENT

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

(2015) Melih Acar et al.   NATURE

Sample preparation for high-resolution 3D confocal imaging of mouse skeletal tissue

(2015) Anjali P Kusumbe et al.   Nature Protocols

A look behind the scenes: the risk and pathogenesis of primary osteoporosis

(2015) Gretl Hendrickx et al.   Nature Reviews Rheumatology

Regulation of tissue morphogenesis by endothelial cell-derived signals

(2015) Saravana K. Ramasamy et al.   TRENDS IN CELL BIOLOGY

The Multifaceted Role of the Vasculature in Endochondral Fracture Repair

(2015) Chelsea S. Bahney et al.   Frontiers in Endocrinology

Osteoblast recruitment to sites of bone formation in skeletal development, homeostasis, and regeneration

(2015) Naomi Dirckx et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Application of VEGFA and FGF-9 Enhances Angiogenesis, Osteogenesis and Bone Remodeling in Type 2 Diabetic Long Bone Regeneration

(2015) Christoph Wallner et al.   PLoS One

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fracture healing: mechanisms and interventions

(2014) Thomas A. Einhorn et al.   Nature Reviews Rheumatology

Effect of basic fibroblast growth factor on angiogenesis and bone regeneration in non-critical-size bone defects in rat calvaria

(2014) Risa Kigami et al.   Journal of Oral Science

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

Angiogenesis and intramembranous osteogenesis

(2013) Christopher J. Percival et al.   DEVELOPMENTAL DYNAMICS

Haematopoietic stem cell niches: new insights inspire new questions

(2013) Fernando Ugarte et al.   EMBO JOURNAL

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Postischemic Revascularization: From Cellular and Molecular Mechanisms to Clinical Applications

(2013) Jean-Sébastien Silvestre et al.   PHYSIOLOGICAL REVIEWS

Bone Vascularization in Normal and Disease Conditions

(2013) Christian Carulli et al.   Frontiers in Endocrinology

HIF1  is a central regulator of collagen hydroxylation and secretion under hypoxia during bone development

(2012) L. Bentovim et al.   DEVELOPMENT

Identification of a clonally expanding haematopoietic compartment in bone marrow

(2012) Lin Wang et al.   EMBO JOURNAL

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation

(2012) Guiqian Chen et al.   International Journal of Biological Sciences

Role of FGFs/FGFRs in skeletal development and bone regeneration

(2012) Xiaolan Du et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Hypoxia-driven pathways in bone development, regeneration and disease

(2012) Christa Maes et al.   Nature Reviews Rheumatology

DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling

(2012) Jung-Min Kim et al.   Nature Communications

Inhibition of cellular senescence by developmentally regulated FGF receptors in mesenchymal stem cells

(2011) D. L. Coutu et al.   BLOOD

Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures

(2011) K. Glomski et al.   BLOOD

Structure and quantification of microvascularisation within mouse long bones: What and how should we measure?

(2011) Bernard Roche et al.   BONE

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways

(2011) D. Ikegami et al.   DEVELOPMENT

Coordinating cell behaviour during blood vessel formation

(2011) I. Geudens et al.   DEVELOPMENT

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

FGF-dependent regulation of VEGF receptor 2 expression in mice

(2011) Masahiro Murakami et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification

(2010) T. Hattori et al.   DEVELOPMENT

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation

(2010) N. Ortega et al.   Disease Models & Mechanisms

VEGF and its role in the early development of the long bone epiphysis

(2010) Doris Allerstorfer et al.   JOURNAL OF ANATOMY

Inhibition of TGF-β signaling by 1D11 antibody treatment increases bone mass and quality in vivo

(2010) James R Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells

(2010) Tom T. Chen et al.   JOURNAL OF CELL BIOLOGY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Fgf-9 is required for angiogenesis and osteogenesis in long bone repair

(2010) B. Behr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124

(2010) F. Kuhnert et al.   SCIENCE

VEGFRs and Notch: a dynamic collaboration in vascular patterning: Figure 1

(2009) Lars Jakobsson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of Akt1 in terminal stages of endochondral bone formation: Angiogenesis and ossification

(2009) Veronica Ulici et al.   BONE

Oxygen Sensors at the Crossroad of Metabolism

(2009) Julián Aragonés et al.   Cell Metabolism

The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf

(2009) I. Eshkar-Oren et al.   DEVELOPMENT

The Role of Hypoxia in Development of the Mammalian Embryo

(2009) Sally L. Dunwoodie   DEVELOPMENTAL CELL

Fibroblast growth factor expression during skeletal fracture healing in mice

(2009) Gregory J. Schmid et al.   DEVELOPMENTAL DYNAMICS

Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

(2009) Christa Maes et al.   EMBO JOURNAL

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

(2009) Ernestina Schipani et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of hypoxia-inducible factor-1α in angiogenic–osteogenic coupling

(2009) Ryan C. Riddle et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands

(2009) Y. Cao   Science Signaling

VEGFR1 Tyrosine Kinase Signaling Promotes Lymphangiogenesis as Well as Angiogenesis Indirectly via Macrophage Recruitment

(2008) Masato Murakami et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dimorphic effects of Notch signaling in bone homeostasis

(2008) Feyza Engin et al.   NATURE MEDICINE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE