Biochemical and cellular functions of P4ATPases

Liver disease without flipping: New functions of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1

(2010) Paul A. Dawson   HEPATOLOGY

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells

(2010) Patricia M. Verhulst et al.   HEPATOLOGY

Intracellular Targeting Signals and Lipid Specificity Determinants of the ALA/ALIS P4-ATPase Complex Reside in the Catalytic ALA α-Subunit

(2010) Rosa L. López-Marqués et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanism and significance of P4 ATPase-catalyzed lipid transport: Lessons from a Na+/K+-pump

(2009) Catheleyne F. Puts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Linking phospholipid flippases to vesicle-mediated protein transport

(2009) Baby-Periyanayaki Muthusamy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inter-subunit interaction of gastric H+,K+-ATPase prevents reverse reaction of the transport cycle

(2009) Kazuhiro Abe et al.   EMBO JOURNAL

Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol

(2009) Anne-Marie Marzesco et al.   FEBS LETTERS

Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrate

(2009) Lieke M. van der Velden et al.   HEPATOLOGY

Localization, Purification, and Functional Reconstitution of the P4-ATPase Atp8a2, a Phosphatidylserine Flippase in Photoreceptor Disc Membranes

(2009) Jonathan A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p

(2009) Guillaume Lenoir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of phosphatidylserine to membrane surface charge and protein targeting during phagosome maturation

(2009) Tony Yeung et al.   JOURNAL OF CELL BIOLOGY

Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues

(2009) Timothy A. Schulz et al.   JOURNAL OF CELL BIOLOGY

Identification of a novel mouse P4-ATPase family member highly expressed during spermatogenesis

(2009) P. Xu et al.   JOURNAL OF CELL SCIENCE

A P4-ATPase Protein Interaction Network Reveals a Link between Aminophospholipid Transport and Phosphoinositide Metabolism

(2009) Catheleyne F. Puts et al.   JOURNAL OF PROTEOME RESEARCH

Control of Protein and Sterol Trafficking by Antagonistic Activities of a Type IV P-type ATPase and Oxysterol Binding Protein Homologue

(2009) Baby-Periyanayaki Muthusamy et al.   MOLECULAR BIOLOGY OF THE CELL

Crystal structure of the sodium–potassium pump at 2.4 Å resolution

(2009) Takehiro Shinoda et al.   NATURE

Regulation of a Golgi flippase by phosphoinositides and an ArfGEF

(2009) Paramasivam Natarajan et al.   NATURE CELL BIOLOGY

IRREGULAR TRICHOME BRANCH 2(ITB2) encodes a putative aminophospholipid translocase that regulates trichome branch elongation in Arabidopsis

(2009) Xiaoguo Zhang et al.   PLANT JOURNAL

ATP8B1 is essential for maintaining normal hearing

(2009) J. M. Stapelbroek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeast

(2009) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A protein kinase network regulates the function of aminophospholipid flippases

(2009) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P-Type ATPase TAT-2 Negatively Regulates Monomethyl Branched-Chain Fatty Acid Mediated Function in Post-Embryonic Growth and Development in C. elegans

(2009) Emylie Seamen et al.   PLoS Genetics

Association study of the 15q11-q13 maternal expression domain in Japanese autistic patients

(2008) Chieko Kato et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Impact of Human Donor Lung Gene Expression Profiles on Survival after Lung Transplantation: A Case-Control Study

(2008) M. Anraku et al.   AMERICAN JOURNAL OF TRANSPLANTATION

How lipid flippases can modulate membrane structure

(2008) Philippe F. Devaux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the C. elegans putative aminophospholipid translocases

(2008) Nicholas N Lyssenko et al.   BMC DEVELOPMENTAL BIOLOGY

Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: Efficient identification of known microduplications and identification of a novel microduplication in ASMT

(2008) Guiqing Cai et al.   BMC Medical Genomics

Abcg5/8 Independent Biliary Cholesterol Excretion in Atp8b1-Deficient Mice

(2008) Annemiek Groen et al.   GASTROENTEROLOGY

ATP8B1 Deficiency Disrupts the Bile Canalicular Membrane Bilayer Structure in Hepatocytes, But FXR Expression and Activity Are Maintained

(2008) Shi–Ying Cai et al.   GASTROENTEROLOGY

Global Screening of Genes Essential for Growth in High-Pressure and Cold Environments: Searching for Basic Adaptive Strategies Using a Yeast Deletion Library

(2008) F. Abe et al.   GENETICS

The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor

(2008) Tamara Frankenberg et al.   HEPATOLOGY

Gender influences monoallelic expression of ATP10A in human brain

(2008) Amber Hogart et al.   HUMAN GENETICS

Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase

(2008) Ting Cai et al.   JOURNAL OF CELL BIOLOGY

Protein Kinases Fpk1p and Fpk2p are Novel Regulators of Phospholipid Asymmetry

(2008) Kenzi Nakano et al.   MOLECULAR BIOLOGY OF THE CELL

P4-ATPase Requirement for AP-1/Clathrin Function in Protein Transport from the trans-Golgi Network and Early Endosomes

(2008) Ke Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Novel therapeutic applications of cardiac glycosides

(2008) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Arabidopsis P4-ATPase ALA3 Localizes to the Golgi and Requires a  -Subunit to Function in Lipid Translocation and Secretory Vesicle Formation

(2008) L. R. Poulsen et al.   PLANT CELL

Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol

(2008) Yvonne Lange et al.   PROGRESS IN LIPID RESEARCH

Expression of Atp8b3 in murine testis and its characterization as a testis specific P-type ATPase

(2008) Eun-Yeung Gong et al.   REPRODUCTION

Role of C. elegans TAT-1 Protein in Maintaining Plasma Membrane Phosphatidylserine Asymmetry

(2008) M. Darland-Ransom et al.   SCIENCE

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE

The C. elegans P4-ATPase TAT-1 Regulates Lysosome Biogenesis and Endocytosis

(2008) Anne-Françoise Ruaud et al.   TRAFFIC