Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

(2015) Anna Bal-Price et al.   ARCHIVES OF TOXICOLOGY

Putative adverse outcome pathways relevant to neurotoxicity

(2015) Anna Bal-Price et al.   CRITICAL REVIEWS IN TOXICOLOGY

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

(2015) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: A case study of lindane-induced neurotoxicity

(2015) Edward L. Croom et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Predictive Endocrine Testing in the 21st Century Using in Vitro Assays of Estrogen Receptor Signaling Responses

(2014) Daniel M. Rotroff et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Neurobehavioural effects of developmental toxicity

(2014) Philippe Grandjean et al.   LANCET NEUROLOGY

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

(2014) Nicole C Kleinstreuer et al.   NATURE BIOTECHNOLOGY

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

(2014) Knut Erik Tollefsen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation

(2014) Anna Bal-Price   ALTEX-Alternatives to Animal Experimentation

Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice

(2013) Marcel Leist et al.   ARCHIVES OF TOXICOLOGY

Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention

(2013) Martine Bellanger et al.   Environmental Health

HDAC inhibitors dysregulate neural stem cell activity in the postnatal mouse brain

(2013) Stacey Beth Foti et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Aging-Induced Nrf2-ARE Pathway Disruption in the Subventricular Zone Drives Neurogenic Impairment in Parkinsonian Mice via PI3K-Wnt/ -Catenin Dysregulation

(2013) F. L'Episcopo et al.   JOURNAL OF NEUROSCIENCE

Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3β/β-catenin pathway

(2012) Hyo Sang Go et al.   NEUROPHARMACOLOGY

Automated neurosphere sorting and plating by the COPAS large particle sorter is a suitable method for high-throughput 3D in vitro applications

(2012) K. Gassmann et al.   TOXICOLOGY IN VITRO

Comparative sensitivity of human and rat neural cultures to chemical-induced inhibition of neurite outgrowth

(2011) Joshua A. Harrill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Use of comparative genomics approaches to characterize interspecies differences in response to environmental chemicals: Challenges, opportunities, and research needs

(2011) Sarah L. Burgess-Herbert et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Accelerated Recruitment of New Brain Development Genes into the Human Genome

(2011) Yong E. Zhang et al.   PLOS BIOLOGY

MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates

(2011) Mehmet Somel et al.   PLOS BIOLOGY

A different approach to validating screening assays for developmental toxicity

(2010) George P. Daston et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Species-Specific Differential AhR Expression Protects Human Neural Progenitor Cells against Developmental Neurotoxicity of PAHs

(2010) Kathrin Gassmann et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Expression of Aryl Hydrocarbon Receptor in Human Placentas and Fetal Tissues

(2010) Yi-zhou Jiang et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

(2010) Daniel M. Rotroff et al.   TOXICOLOGICAL SCIENCES

DNA repair modulates the vulnerability of the developing brain to alkylating agents

(2009) G.E. Kisby et al.   DNA REPAIR

Human Neurospheres as Three-Dimensional Cellular Systems for Developmental Neurotoxicity Testing

(2009) Michaela Moors et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells

(2009) Angel Ayuso-Sacido et al.   JOURNAL OF NEURO-ONCOLOGY

Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: State of the science

(2009) Joseph M. Breier et al.   NEUROTOXICOLOGY AND TERATOLOGY

Bringing toxicology into the 21st century: A global call to action

(2009) T. Seidle et al.   TOXICOLOGY IN VITRO

Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase

(2007) Dongren Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY