The mechanical impact of col11a2 loss on joints; col11a2 mutant zebrafish show changes to joint development and function, which leads to early-onset osteoarthritis

Precise spatial restriction of BMP signaling in developing joints is perturbed upon loss of embryo movement

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Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice

(2018) Claes Ohlsson et al.   JOURNAL OF ENDOCRINOLOGY

Stresses and strains on the human fetal skeleton during development

(2018) Stefaan W. Verbruggen et al.   Journal of the Royal Society Interface

Investigation of the relationship between susceptibility loci for hip osteoarthritis and DXA-derived hip shape in a population based cohort of peri-menopausal women

(2018) Denis A. Baird et al.   Arthritis & Rheumatology

Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape

(2017) Rebecca A. Rolfe et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Effect of crosslinking in cartilage-like collagen microstructures

(2017) Ying-chun Chen et al.   Journal of the Mechanical Behavior of Biomedical Materials

WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis

(2016) Giovanna Nalesso et al.   ANNALS OF THE RHEUMATIC DISEASES

The role of embryo movement in the development of the furcula

(2016) A. S. Pollard et al.   JOURNAL OF ANATOMY

Structural and mechanical properties of the proliferative zone of the developing murine growth plate cartilage assessed by atomic force microscopy

(2016) Carina Prein et al.   MATRIX BIOLOGY

Differential effects of altered patterns of movement and strain on joint cell behaviour and skeletal morphogenesis

(2016) L.H. Brunt et al.   OSTEOARTHRITIS AND CARTILAGE

Joint Development Involves a Continuous Influx of Gdf5-Positive Cells

(2016) Yulia Shwartz et al.   Cell Reports

Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair

(2016) Yujie Deng et al.   Cell Reports

Ancient origin of lubricated joints in bony vertebrates

(2016) Amjad Askary et al.   eLife

Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development

(2015) Lucy H. Brunt et al.   JOURNAL OF BIOMECHANICS

Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells

(2015) Alexandra Karystinou et al.   ARTHRITIS RESEARCH & THERAPY

Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways

(2014) Rebecca A Rolfe et al.   BMC GENOMICS

Histology, Glycosaminoglycan Level and Cartilage Stiffness in Monoiodoacetate-Induced Osteoarthritis: Comparative Analysis with Anterior Cruciate Ligament Transection in Rat Model and Human Osteoarthritis

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Immobilized chicks as a model system for early-onset developmental dysplasia of the hip

(2014) Niamh C. Nowlan et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Novel pathogenic COL11A1/COL11A2 variants in Stickler syndrome detected by targeted NGS and exome sequencing

(2014) Frederic R. Acke et al.   MOLECULAR GENETICS AND METABOLISM

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

(2014) Sofia Movérare-Skrtic et al.   NATURE MEDICINE

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution

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Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis

(2013) Ashish Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Missense polymorphisms of the WNT16 gene are associated with bone mass, hip geometry and fractures

(2013) C. García-Ibarbia et al.   OSTEOPOROSIS INTERNATIONAL

Spinal Deformity in Aged Zebrafish Is Accompanied by Degenerative Changes to Their Vertebrae that Resemble Osteoarthritis

(2013) Anthony J. Hayes et al.   PLoS One

The Roles of Mechanical Stresses in the Pathogenesis of Osteoarthritis

(2013) Joseph A. Buckwalter et al.   Cartilage

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

Evolution of the osteoblast: skeletogenesis in gar and zebrafish

(2012) B Frank Eames et al.   BMC EVOLUTIONARY BIOLOGY

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Muscle contraction controls skeletal morphogenesis through regulation of chondrocyte convergent extension

(2012) Yulia Shwartz et al.   DEVELOPMENTAL BIOLOGY

Age-related variations in the biomechanical properties of human sclera

(2012) Brendan Geraghty et al.   Journal of the Mechanical Behavior of Biomedical Materials

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure

(2012) Xiyi Chen et al.   Nature Protocols

New tools for studying osteoarthritis genetics in zebrafish

(2012) R.E. Mitchell et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis

(2011) J. H. Waarsing et al.   ARTHRITIS AND RHEUMATISM

Mechanical Influences on Morphogenesis of the Knee Joint Revealed through Morphological, Molecular and Computational Analysis of Immobilised Embryos

(2011) Karen A. Roddy et al.   PLoS One

The expression patterns of minor fibrillar collagens during development in zebrafish

(2010) Ming Fang et al.   GENE EXPRESSION PATTERNS

Early-onset progressive osteoarthritis with hereditary progressive ophtalmopathy or Stickler syndrome

(2010) Tifenn Couchouron et al.   JOINT BONE SPINE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling

(2009) C. L. Hammond et al.   DEVELOPMENT

Muscle Contraction Is Necessary to Maintain Joint Progenitor Cell Fate

(2009) Joy Kahn et al.   DEVELOPMENTAL CELL

Craniofacial cartilage morphogenesis requires zebrafish col11a1 activity

(2009) Dominique Baas et al.   MATRIX BIOLOGY

The Basic Science of Articular Cartilage: Structure, Composition, and Function

(2009) Alice J. Sophia Fox et al.   Sports Health-A Multidisciplinary Approach

Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis

(2008) Francesco Dell'Accio et al.   ARTHRITIS AND RHEUMATISM

Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity

(2008) S. Elworthy et al.   DEVELOPMENT

Regulation of Zebrafish Skeletogenesis by ext2/dackel and papst1/pinscher

(2008) Aurélie Clément et al.   PLoS Genetics

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols