Delivery and Targeting of miRNAs for Treating Liver Fibrosis

microRNA-222 modulates liver fibrosis in a murine model of biliary atresia

(2014) Wen-jun Shen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chemical modifications of DNA for study of helicase mechanisms

(2014) Kevin D. Raney   BIOORGANIC & MEDICINAL CHEMISTRY

Overexpression of miR-126 Inhibits the Activation and Migration of HSCs through Targeting CRK

(2014) Xu-Hua Gong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis

(2014) Jing-Jing Yang et al.   CELLULAR SIGNALLING

S-adenosylmethionine inhibits the activated phenotype of human hepatic stellate cells via Rac1 and Matrix metalloproteinases

(2014) Feng Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice

(2014) Fuyuan Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway

(2014) Xiaolong Tu et al.   JOURNAL OF PATHOLOGY

Hepatitis C Virus-Induced Changes in MicroRNA 107 (miRNA-107) and miRNA-449a Modulate CCL2 by Targeting the Interleukin-6 Receptor Complex in Hepatitis

(2014) N. J. Sarma et al.   JOURNAL OF VIROLOGY

Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy

(2014) Carla L Esposito et al.   MOLECULAR THERAPY

A-to-I editing in the miRNA seed region regulates target mRNA selection and silencing efficiency

(2014) Hideaki Kume et al.   NUCLEIC ACIDS RESEARCH

Nanotechnology applications for the therapy of liver fibrosis

(2014) Lydia Giannitrapani   WORLD JOURNAL OF GASTROENTEROLOGY

miR-106b-25/miR-17-92clusters: Polycistrons with oncogenic roles in hepatocellular carcinoma

(2014) Weiqi Tan   WORLD JOURNAL OF GASTROENTEROLOGY

Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia

(2014) Yoko Endo-Takahashi et al.   Scientific Reports

Efficient Pro-survival/angiogenic miRNA Delivery by an MRI-Detectable Nanomaterial

(2013) Renata S. M. Gomes et al.   ACS Nano

Stable RNA nanoparticles as potential new generation drugs for cancer therapy

(2013) Yi Shu et al.   ADVANCED DRUG DELIVERY REVIEWS

Neovessel formation promotes liver fibrosis via providing latent transforming growth factor-β

(2013) Kotaro Sakata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial cell TIMP-1 is upregulated by shear stress via Sp-1 and the TGFβ1 signaling pathways

(2013) Cassandra Uchida et al.   Biochemistry and Cell Biology

Cationic microRNA-delivering nanovectors with bifunctional peptides for efficient treatment of PANC-1 xenograft model

(2013) Q.L. Hu et al.   BIOMATERIALS

miR-148b–Nanoparticle conjugates for light mediated osteogenesis of human adipose stromal/stem cells

(2013) Ammar T. Qureshi et al.   BIOMATERIALS

MicroRNA-21 activates hepatic stellate cells via PTEN/Akt signaling

(2013) Jun Wei et al.   BIOMEDICINE & PHARMACOTHERAPY

Profibrotic effect of miR-33a with Akt activation in hepatic stellate cells

(2013) Zhuo-Jian Li et al.   CELLULAR SIGNALLING

miR-126 in human cancers: Clinical roles and current perspectives

(2013) Faeza Ebrahimi et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells

(2013) Li Chen et al.   HEPATOLOGY

Non-Coding RNAs: Multi-Tasking Molecules in the Cell

(2013) Anita Gomes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peroxisome Proliferator-Activated Receptor-γ Activators Monascin and Rosiglitazone Attenuate Carboxymethyllysine-Induced Fibrosis in Hepatic Stellate Cells through Regulating the Oxidative Stress Pathway but Independent of the Receptor for Advanced Glycation End Products Signaling

(2013) Wei-Hsuan Hsu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Relaxin decreases the severity of established hepatic fibrosis in mice

(2013) Robert G. Bennett et al.   LIVER INTERNATIONAL

Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor

(2013) Shu-hao Hsu et al.   Nanomedicine-Nanotechnology Biology and Medicine

MicroRNAs in liver disease

(2013) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines

(2013) Pasqualino de Antonellis et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

In vitro optimization of 2′-OMe-4′-thioribonucleoside–modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle

(2013) Mayumi Takahashi et al.   NUCLEIC ACIDS RESEARCH

Effect of ghrelin on chronic liver injury and fibrogenesis in male rats: Possible role of nitric oxide

(2013) Nashwa N. Kabil et al.   PEPTIDES

Nanomedicines of Hedgehog Inhibitor and PPAR-γ Agonist for Treating Liver Fibrosis

(2013) Virender Kumar et al.   PHARMACEUTICAL RESEARCH

Transforming Growth Factor β Neutralization Ameliorates Pre-Existing Hepatic Fibrosis and Reduces Cholangiocarcinoma in Thioacetamide-Treated Rats

(2013) Hong Ling et al.   PLoS One

Hepatitis C Virus Induced miR200c Down Modulates FAP-1, a Negative Regulator of Src Signaling and Promotes Hepatic Fibrosis

(2013) Sabarinathan Ramachandran et al.   PLoS One

miR-181b Promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients

(2012) Baocan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A New Strategy for Treatment of Liver Fibrosis

(2012) Shao-Long Chen et al.   BIODRUGS

MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4

(2012) Yong He et al.   CELLULAR SIGNALLING

Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review

(2012) V. Sanchez-Valle et al.   CURRENT MEDICINAL CHEMISTRY

Development of a microRNA delivery system based on bacteriophage MS2 virus-like particles

(2012) Yang Pan et al.   FEBS Journal

miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma

(2012) H.M. El Tayebi et al.   FEBS LETTERS

Identification of novel mechanisms of silymarin on the carbon tetrachloride-induced liver fibrosis in mice by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis

(2012) Chia-Cheng Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism

(2012) Yuping Chen et al.   GASTROENTEROLOGY

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis

(2012) Tomohiro Ogawa et al.   GUT

Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis

(2012) Ashley M. Lakner et al.   HEPATOLOGY

miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression

(2012) Jiang Li et al.   JOURNAL OF HEPATOLOGY

Cardiotrophin-1 reduces ischemia/reperfusion injury during liver transplant

(2012) Patricia Aguilar-Melero et al.   JOURNAL OF SURGICAL RESEARCH

Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate

(2012) Youngchul Kim et al.   LIVER INTERNATIONAL

Hepatitis C Virus Mediated Changes in miRNA-449a Modulates Inflammatory Biomarker YKL40 through Components of the NOTCH Signaling Pathway

(2012) Nayan J. Sarma et al.   PLoS One

Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-β receptor-mediated ERK and p38 pathways

(2012) Feng Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Stability of miRNA 5′terminal and seed regions is correlated with experimentally observed miRNA-mediated silencing efficacy

(2012) Naoki Hibio et al.   Scientific Reports

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Suppression of hepatic stellate cell activation by microRNA-29b

(2011) Yumiko Sekiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma

(2011) Jin Hou et al.   CANCER CELL

MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma

(2011) A. F. Ibrahim et al.   CANCER RESEARCH

Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation

(2011) Chao Chen et al.   EXPERIMENTAL CELL RESEARCH

The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats

(2011) Wei-Qing Li et al.   FEBS Journal

Chemical modification and design of anti-miRNA oligonucleotides

(2011) K A Lennox et al.   GENE THERAPY

Imatinib Mesylate Improves Liver Regeneration and Attenuates Liver Fibrogenesis in CCL4-Treated Mice

(2011) Wen-Ling Kuo et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Application of RNA interference in treating human diseases

(2011) S. Abdolhamid Angaji et al.   JOURNAL OF GENETICS

Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice

(2011) D. Pramanik et al.   MOLECULAR CANCER THERAPEUTICS

Cyclopamine Attenuates Acute Warm Ischemia Reperfusion Injury in Cholestatic Rat Liver: Hope for Marginal Livers

(2011) Akshay Pratap et al.   MOLECULAR PHARMACEUTICS

GFAP Promoter-Driven RNA Interference on TGF-β1 to Treat Liver Fibrosis

(2011) Ningning Yang et al.   PHARMACEUTICAL RESEARCH

Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes

(2011) S. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis

(2010) Yury Popov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Triplex forming oligonucleotides against type α1(I) collagen attenuates liver fibrosis induced by bile duct ligation

(2010) Ravikiran Panakanti et al.   BIOCHEMICAL PHARMACOLOGY

Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation

(2010) Lin Zhu et al.   BIOCONJUGATE CHEMISTRY

Colchicine poisoning: the dark side of an ancient drug

(2010) Yaron Finkelstein et al.   CLINICAL TOXICOLOGY

Got target?: computational methods for microRNA target prediction and their extension

(2010) Hyeyoung Min et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Efficient and targeted delivery of siRNA in vivo

(2010) Min Suk Shim et al.   FEBS Journal

Signals from dying hepatocytes trigger growth of liver progenitors

(2010) Y. Jung et al.   GUT

Dendritic cells in liver fibrosis: conductor of the inflammatory orchestra?

(2010) Costica Aloman et al.   HEPATOLOGY

Anti-PDGF-B monoclonal antibody reduces liver fibrosis development

(2010) Shinji Ogawa et al.   HEPATOLOGY RESEARCH

Down-regulation of cyclin E1 expression by microrna-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation

(2010) Yumiko Sekiya et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans

(2010) Rebecca T Marquez et al.   LABORATORY INVESTIGATION

Targeted Delivery of Antisense Inhibitor of miRNA for Antiangiogenesis Therapy Using cRGD-Functionalized Nanoparticles

(2010) Xi-Qiu Liu et al.   MOLECULAR PHARMACEUTICS

Nanoparticles Modified With Tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy

(2010) Yunching Chen et al.   MOLECULAR THERAPY

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

Small RNA sorting: matchmaking for Argonautes

(2010) Benjamin Czech et al.   NATURE REVIEWS GENETICS

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Making RISC

(2010) Tomoko Kawamata et al.   TRENDS IN BIOCHEMICAL SCIENCES

Transcriptional regulation of hepatic stellate cells

(2009) Jelena Mann et al.   ADVANCED DRUG DELIVERY REVIEWS

siRNA vs. shRNA: Similarities and differences

(2009) Donald D. Rao et al.   ADVANCED DRUG DELIVERY REVIEWS

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis

(2009) Steve S. Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

HPMA Polymer-Based Site-Specific Delivery of Oligonucleotides to Hepatic Stellate Cells

(2009) Ningning Yang et al.   BIOCONJUGATE CHEMISTRY

Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation

(2009) Juling Ji et al.   FEBS LETTERS

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis

(2009) Gakuhei Son et al.   HEPATOLOGY

Effect of natural interferon α on proliferation and apoptosis of hepatic stellate cells

(2009) Tomohiro Ogawa et al.   Hepatology International

Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways

(2009) Joy X. Jiang et al.   JOURNAL OF HEPATOLOGY

miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis

(2009) Can-Jie Guo et al.   JOURNAL OF HEPATOLOGY

TGF-β1 Gene Silencing for Treating Liver Fibrosis

(2009) Kun Cheng et al.   MOLECULAR PHARMACEUTICS

Structural determinants of miRNAs for RISC loading and slicer-independent unwinding

(2009) Tomoko Kawamata et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cellular Sources of Extracellular Matrix in Hepatic Fibrosis

(2008) Rebecca G. Wells   Clinics in Liver Disease

Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats

(2008) J. H. Tsai et al.   JOURNAL OF VIRAL HEPATITIS

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

NF-κB signaling, liver disease and hepatoprotective agents

(2008) B Sun et al.   ONCOGENE

The Inhibition of the Highly Expressed Mir-221 and Mir-222 Impairs the Growth of Prostate Carcinoma Xenografts in Mice

(2008) Neri Mercatelli et al.   PLoS One