A New Strategy for Treatment of Liver Fibrosis

MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence

(2016) Bernard S. Marasa et al.   Aging-US

miRNA studies inin vitroandin vivoactivated hepatic stellate cells

(2016) Gunter Maubach   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy: A new player in hepatic stellate cell activation

(2012) Lien F.R. Thoen et al.   Autophagy

Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis

(2012) Ashley M. Lakner et al.   HEPATOLOGY

Role of integrins in fibrosing liver diseases

(2011) Eleonora Patsenker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

MicroRNA-21: A novel therapeutic target in human cancer

(2011) Xuan Pan et al.   CANCER BIOLOGY & THERAPY

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation

(2011) Chao Chen et al.   EXPERIMENTAL CELL RESEARCH

The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats

(2011) Wei-Qing Li et al.   FEBS Journal

Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice

(2011) Ruchi Bansal et al.   HEPATOLOGY

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration and collagen gene expression through the FAK-PI3K-Akt pathway

(2011) Naoki Uyama et al.   LABORATORY INVESTIGATION

Roles of microRNA-29a in the Antifibrotic Effect of Farnesoid X Receptor in Hepatic Stellate Cells

(2011) J. Li et al.   MOLECULAR PHARMACOLOGY

GFAP Promoter-Driven RNA Interference on TGF-β1 to Treat Liver Fibrosis

(2011) Ningning Yang et al.   PHARMACEUTICAL RESEARCH

The Progression of Liver Fibrosis Is Related with Overexpression of the miR-199 and 200 Families

(2011) Yoshiki Murakami et al.   PLoS One

miR-29 Is a Major Regulator of Genes Associated with Pulmonary Fibrosis

(2010) Leah Cushing et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MicroRNA-29, a key regulator of collagen expression in systemic sclerosis

(2010) Britta Maurer et al.   ARTHRITIS AND RHEUMATISM

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

Hepatic stellate cell (vitamin A-storing cell) and its relative – past, present and future

(2010) Haruki Senoo et al.   CELL BIOLOGY INTERNATIONAL

The Roles of MicroRNAs in Heart Diseases: A Novel Important Regulator

(2010) B. Cai et al.   CURRENT MEDICINAL CHEMISTRY

MicroRNAs and the regulation of fibrosis

(2010) Xiaoying Jiang et al.   FEBS Journal

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

(2010) Christoph Roderburg et al.   HEPATOLOGY

miR-21 and miR-31 Converge on TIAM1 to Regulate Migration and Invasion of Colon Carcinoma Cells

(2010) Charisa L. Cottonham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of cyclin E1 expression by microrna-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation

(2010) Yumiko Sekiya et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transcriptional regulation of hepatic stellate cells

(2009) Jelena Mann et al.   ADVANCED DRUG DELIVERY REVIEWS

Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation

(2009) Senthil K. Venugopal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

miR-21as a key regulator of oncogenic processes

(2009) S. Duygu Selcuklu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

MicroRNA-Based Therapeutics for Cancer

(2009) Vivien Wang et al.   BIODRUGS

Hepatic fibrosis

(2009) Jingjing Jiao et al.   CURRENT OPINION IN GASTROENTEROLOGY

Hepatic Stellate Cell-Specific Gene Silencing Induced by an Artificial MicroRNA for Antifibrosis In Vitro

(2009) Ying Chang et al.   DIGESTIVE DISEASES AND SCIENCES

Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation

(2009) Juling Ji et al.   FEBS LETTERS

Now there are many (stages) where before there was one: In search of a pathophysiological classification of cirrhosis

(2009) Guadalupe Garcia-Tsao et al.   HEPATOLOGY

Therapeutic RNA manipulation in liver disease

(2009) Thomas A. Kerr et al.   HEPATOLOGY

Hepatic stellate cell: A star cell in the liver

(2009) Luigi Atzori et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis

(2009) Can-Jie Guo et al.   JOURNAL OF HEPATOLOGY

Advances in antifibrotic therapy

(2009) Zahra Ghiassi-Nejad et al.   Expert Review of Gastroenterology & Hepatology

Getting to the Root of miRNA-Mediated Gene Silencing

(2008) Ana Eulalio et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Liver transplantation: an update 2008

(2008) Adnan Said et al.   CURRENT OPINION IN GASTROENTEROLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

MicroRNAs: Key Modulators of Posttranscriptional Gene Expression

(2008) Steven P. O'Hara et al.   GASTROENTEROLOGY

miR-122, a paradigm for the role of microRNAs in the liver

(2008) Muriel Girard et al.   JOURNAL OF HEPATOLOGY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

(2008) E. van Rooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY