In vitro optimization of 2′-OMe-4′-thioribonucleoside–modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle

Gene Silencing via RNAi and siRNA Quantification in Tumor Tissue Using MEND, a Liposomal siRNA Delivery System

(2013) Yu Sakurai et al.   MOLECULAR THERAPY

A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

(2012) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Intracellular stability of 2′-OMe-4′-thioribonucleoside modified siRNA leads to long-term RNAi effect

(2012) Mayumi Takahashi et al.   NUCLEIC ACIDS RESEARCH

Silencing of microRNA families by seed-targeting tiny LNAs

(2011) Susanna Obad et al.   NATURE GENETICS

MicroRNAs in Development and Disease

(2011) Danish Sayed et al.   PHYSIOLOGICAL REVIEWS

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

A Direct Comparison of Anti-microRNA Oligonucleotide Potency

(2010) Kim A. Lennox et al.   PHARMACEUTICAL RESEARCH

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

(2009) Yanli Wang et al.   NATURE

Synthesis and characterization of 2′-modified-4′-thioRNA: a comprehensive comparison of nuclease stability

(2009) Mayumi Takahashi et al.   NUCLEIC ACIDS RESEARCH

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Investigations toward the selection of fully-modified 4′-thioRNA aptamers: Optimization of in vitro transcription steps in the presence of 4′-thioNTPs

(2008) Noriaki Minakawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

MicroRNA: an Emerging Therapeutic Target and Intervention Tool

(2008) Zhen Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR-21: a small multi-faceted RNA

(2008) Anna M. Krichevsky et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells

(2008) Michael D Horwich et al.   Nature Protocols

Potent inhibition of microRNA in vivo without degradation

(2008) Scott Davis et al.   NUCLEIC ACIDS RESEARCH

Synthesis and crystal structure of 2′-deoxy-2′-fluoro-4′-thioribonucleosides: substrates for the synthesis of novel modified RNAs

(2008) Mayumi Takahashi et al.   TETRAHEDRON

Inhibition of microRNA with antisense oligonucleotides

(2007) Christine C. Esau   METHODS