Cardiac myosin binding protein-C: a novel sarcomeric target for gene therapy

Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomere

(2013) Y. Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pathological Ventricular Remodeling

(2013) Min Xie et al.   CIRCULATION

Potential of gene therapy as a treatment for heart failure

(2013) Roger J. Hajjar   JOURNAL OF CLINICAL INVESTIGATION

E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction

(2013) Willem J. De Lange et al.   JOURNAL OF GENERAL PHYSIOLOGY

Functional dissection of myosin binding protein C phosphorylation

(2013) Manish K. Gupta et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac Myosin Binding Protein C and Its Phosphorylation Regulate Multiple Steps in the Cross-Bridge Cycle of Muscle Contraction

(2012) Arthur T. Coulton et al.   BIOCHEMISTRY

Dissociation of Structural and Functional Phenotypes in Cardiac Myosin-Binding Protein C Conditional Knockout Mice

(2012) Peter.P Chen et al.   CIRCULATION

Cardiac Myosin Binding Protein-C Mutations in Families With Hypertrophic Cardiomyopathy

(2012) Stephen P. Page et al.   Circulation-Cardiovascular Genetics

In Vivo Cardiac Myosin Binding Protein C Gene Transfer Rescues Myofilament Contractile Dysfunction in Cardiac Myosin Binding Protein C Null Mice

(2012) Sergei Merkulov et al.   Circulation-Heart Failure

Myofilament Protein Gene Mutation Screening and Outcome of Patients With Hypertrophic Cardiomyopathy

(2012) Iacopo Olivotto et al.   MAYO CLINIC PROCEEDINGS

Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments

(2012) M. J. Previs et al.   SCIENCE

Roles for Cardiac MyBP-C in Maintaining Myofilament Lattice Rigidity and Prolonging Myosin Cross-Bridge Lifetime

(2011) Bradley M. Palmer et al.   BIOPHYSICAL JOURNAL

Heart Disease and Stroke Statistics—2012 Update

(2011) et al.   CIRCULATION

In the Thick of It

(2011) Samantha P. Harris et al.   CIRCULATION RESEARCH

Cardiac Myosin Binding Protein C Insufficiency Leads to Early Onset of Mechanical Dysfunction

(2011) Candida L. Desjardins et al.   Circulation-Cardiovascular Imaging

Cardiac inotropes: current agents and future directions

(2011) G. Hasenfuss et al.   EUROPEAN HEART JOURNAL

Novel correlations between the genotype and the phenotype of hypertrophic and dilated cardiomyopathy: results from the German Competence Network Heart Failure

(2011) Stephan Waldmüller et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cardiac myosin binding protein C phosphorylation in cardiac disease

(2011) Diederik W. D. Kuster et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study

(2011) John R Teerlink et al.   LANCET

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle

(2010) O'Neal Copeland et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sarcomere Gene Mutations in Hypertrophy and Heart Failure

(2010) Hiroyuki Morita et al.   Journal of Cardiovascular Translational Research

The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy

(2009) L. Carrier et al.   CARDIOVASCULAR RESEARCH

Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy

(2009) Sabine J. van Dijk et al.   CIRCULATION

Evidence From Human Myectomy Samples That MYBPC3 Mutations Cause Hypertrophic Cardiomyopathy Through Haploinsufficiency

(2009) Steven Marston et al.   CIRCULATION RESEARCH

Ca2+-independent positive molecular inotropy for failing rabbit and human cardiac muscle by α-myosin motor gene transfer

(2009) Todd J. Herron et al.   FASEB JOURNAL

A novel approach to improve cardiac performance: cardiac myosin activators

(2009) John R. Teerlink   HEART FAILURE REVIEWS

The Myosin-binding Protein C Motif Binds to F-actin in a Phosphorylation-sensitive Manner

(2009) Justin F. Shaffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Designing Heart Performance by Gene Transfer

(2008) Jennifer Davis et al.   PHYSIOLOGICAL REVIEWS