Potential of gene therapy as a treatment for heart failure

Gene Therapy for Heart Failure

(2012) Lisa Tilemann et al.   CIRCULATION RESEARCH

Percutaneous methods of vector delivery in preclinical models

(2012) D Ladage et al.   GENE THERAPY

Cardiac gene therapy in large animals: bridge from bench to bedside

(2012) K Ishikawa et al.   GENE THERAPY

The AAV Vector Toolkit: Poised at the Clinical Crossroads

(2012) Aravind Asokan et al.   MOLECULAR THERAPY

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)

(2011) Mariell Jessup et al.   CIRCULATION

Heart Disease and Stroke Statistics—2012 Update

(2011) et al.   CIRCULATION

SERCA2a Gene Transfer Decreases Sarcoplasmic Reticulum Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure

(2011) Alexander R. Lyon et al.   Circulation-Arrhythmia and Electrophysiology

Augmentation of left ventricular mechanics by recirculation-mediated AAV2/1-SERCA2a gene delivery in experimental heart failure

(2011) Justin A. Mariani et al.   EUROPEAN JOURNAL OF HEART FAILURE

Delivery of gelfoam-enabled cells and vectors into the pericardial space using a percutaneous approach in a porcine model

(2011) D Ladage et al.   GENE THERAPY

Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia

(2011) C Li et al.   GENE THERAPY

Myocardial gene delivery using molecular cardiac surgery with recombinant adeno-associated virus vectors in vivo

(2011) J D White et al.   GENE THERAPY

Rescuing the Failing Heart by Targeted Gene Transfer

(2011) Yoshiaki Kawase et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

AAV6-βARKct gene delivery mediated by molecular cardiac surgery with recirculating delivery (MCARD) in sheep results in robust gene expression and increased adrenergic reserve

(2011) Michael G. Katz et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

SUMO1-dependent modulation of SERCA2a in heart failure

(2011) Changwon Kho et al.   NATURE

Effects of CXCR4 Gene Transfer on Cardiac Function After Ischemia-Reperfusion Injury

(2010) Jiqiu Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Gene Delivery of Sarcoplasmic Reticulum Calcium ATPase Inhibits Ventricular Remodeling in Ischemic Mitral Regurgitation

(2010) Ronen Beeri et al.   Circulation-Heart Failure

β2-Adrenergic Receptor Signaling in the Cardiac Myocyte is Modulated by Interactions With CXCR4

(2010) Thomas J LaRocca et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

SERCA2a Gene Transfer Enhances eNOS Expression and Activity in Endothelial Cells

(2010) Lahouaria Hadri et al.   MOLECULAR THERAPY

SDF-1α as a therapeutic stem cell homing factor in myocardial infarction

(2010) Santhosh K. Ghadge et al.   PHARMACOLOGY & THERAPEUTICS

Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives

(2010) Francesco Vetrini et al.   Viruses-Basel

Long-Term Cardiac-Targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy

(2009) Lennart Suckau et al.   CIRCULATION

Inducible Expression of Active Protein Phosphatase-1 Inhibitor-1 Enhances Basal Cardiac Function and Protects Against Ischemia/Reperfusion Injury

(2009) Persoulla Nicolaou et al.   CIRCULATION RESEARCH

Targeted SERCA2a Gene Expression Identifies Molecular Mechanism and Therapeutic Target for Arrhythmogenic Cardiac Alternans

(2009) Michael J. Cutler et al.   Circulation-Arrhythmia and Electrophysiology

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID Trial), a First-in-Human Phase 1/2 Clinical Trial

(2009) Brian E. Jaski et al.   JOURNAL OF CARDIAC FAILURE

Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses

(2009) Roberto Calcedo et al.   JOURNAL OF INFECTIOUS DISEASES

Prevention of Ventricular Arrhythmias With Sarcoplasmic Reticulum Ca 2+ ATPase Pump Overexpression in a Porcine Model of Ischemia Reperfusion

(2008) Fabrice Prunier et al.   CIRCULATION

G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

(2008) Philip W. Raake et al.   CIRCULATION RESEARCH

Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals

(2008) M J Byrne et al.   GENE THERAPY

Design of a Phase 1/2 Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Heart Failure

(2008) Roger J. Hajjar et al.   JOURNAL OF CARDIAC FAILURE

Reversal of Cardiac Dysfunction After Long-Term Expression of SERCA2a by Gene Transfer in a Pre-Clinical Model of Heart Failure

(2008) Yoshiaki Kawase et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Percutaneous Transendocardial Delivery of Self-complementary Adeno-associated Virus 6 Achieves Global Cardiac Gene Transfer in Canines

(2008) Lawrence T Bish et al.   MOLECULAR THERAPY

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE