Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

 -Glucan Activates Microglia without Inducing Cytokine Production in Dectin-1-Dependent Manner

(2014) V. B. Shah et al.   JOURNAL OF IMMUNOLOGY

Induction of Innate Immune Response through TLR2 and Dectin 1 Prevents Type 1 Diabetes

(2014) S. Karumuthil-Melethil et al.   JOURNAL OF IMMUNOLOGY

The Induction of Inflammation by Dectin-1 In Vivo Is Dependent on Myeloid Cell Programming and the Progression of Phagocytosis

(2014) M. Rosas et al.   JOURNAL OF IMMUNOLOGY

Lack of Toll IL-1R8 Exacerbates Th17 Cell Responses in Fungal Infection

(2014) S. Bozza et al.   JOURNAL OF IMMUNOLOGY

Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells

(2014) H. S. Goodridge et al.   JOURNAL OF IMMUNOLOGY

CLEC-2 activates Syk through dimerization

(2010) C. E. Hughes et al.   BLOOD

The incidence of acute graft-versus-host disease increases with Candida colonization depending the dectin-1 gene status

(2010) Walter J.F.M. van der Velden et al.   CLINICAL IMMUNOLOGY

Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

(2010) Shinobu Saijo et al.   IMMUNITY

C-type lectin Langerin is a β-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi

(2010) Marein A.W.P. de Jong et al.   MOLECULAR IMMUNOLOGY

Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis

(2010) Theo S Plantinga et al.   ARTHRITIS RESEARCH & THERAPY

β-Glucans and Dectin-1

(2009) S. Vicky Tsoni et al.   Annals of the New York Academy of Sciences

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

Innate immune responses toMycobacterium ulceransvia toll-like receptors and dectin-1 in human keratinocytes

(2009) Hye-Mi Lee et al.   CELLULAR MICROBIOLOGY

Early Stop Polymorphism in Human DECTIN‐1 Is Associated with IncreasedCandidaColonization in Hematopoietic Stem Cell Transplant Recipients

(2009) Theo S. Plantinga et al.   CLINICAL INFECTIOUS DISEASES

Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis

(2009) Tammy R. Ozment-Skelton et al.   CRITICAL CARE MEDICINE

Pattern recognition: recent insights from Dectin-1

(2009) Delyth M Reid et al.   CURRENT OPINION IN IMMUNOLOGY

Requirement of phospholipase C-γ2 (PLCγ2) for Dectin-1-induced antigen presentation and induction of TH1/TH17 polarization

(2009) Ilaria Tassi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Approaching the Asymptote: 20 Years Later

(2009) Ruslan Medzhitov   IMMUNITY

β-glucan recognition by the innate immune system

(2009) Helen S. Goodridge et al.   IMMUNOLOGICAL REVIEWS

Genetic variability of innate immunity impacts human susceptibility to fungal diseases

(2009) Agostinho Carvalho et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Phospholipase Cγ2 Is Critical for Dectin-1-mediated Ca2+Flux and Cytokine Production in Dendritic Cells

(2009) Shengli Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36

(2009) Terry K. Means et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

(2009) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

(2009) Matthew J. Robinson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requisite Role for the Dectin-1  -Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus

(2009) J. L. Werner et al.   JOURNAL OF IMMUNOLOGY

Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk

(2009) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections

(2009) Bart Ferwerda et al.   NEW ENGLAND JOURNAL OF MEDICINE

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome

(2009) J. Vera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Analysis of Innate Immunity in Crohn's Disease and Ulcerative Colitis Identifies Two Susceptibility Loci Harboring CARD9 and IL18RAP

(2008) Alexandra Zhernakova et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses

(2008) S. LeibundGut-Landmann et al.   BLOOD

IL-17 contributes to CD4-mediated graft-versus-host disease

(2008) L. W. Kappel et al.   BLOOD

In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations

(2008) M. J. Carlson et al.   BLOOD

Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation

(2008) A H Elmaagacli et al.   BONE MARROW TRANSPLANTATION

Mycobacterium abscessusactivates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1

(2008) Dong-Min Shin et al.   CELLULAR MICROBIOLOGY

Host–microbe interactions: innate pattern recognition of fungal pathogens

(2008) Frank L van de Veerdonk et al.   CURRENT OPINION IN MICROBIOLOGY

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

(2008) Kevin M. Dennehy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DC activated via dectin-1 convert Treg into IL-17 producers

(2008) Fabiola Osorio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CLEC9A Is a Novel Activation C-type Lectin-like Receptor Expressed on BDCA3+Dendritic Cells and a Subset of Monocytes

(2008) Cristal Huysamen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scavenger Receptor Collectin Placenta 1 (CL-P1) Predominantly Mediates Zymosan Phagocytosis by Human Vascular Endothelial Cells

(2008) SeongJae Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspofungin Modulates Inflammatory Responses toAspergillus fumigatusthrough Stage‐Specific Effects on Fungal β‐Glucan Exposure

(2008) T. M. Hohl et al.   JOURNAL OF INFECTIOUS DISEASES

Caspofungin‐Mediated β‐Glucan Unmasking and Enhancement of Human Polymorphonuclear Neutrophil Activity againstAspergillusand Non‐AspergillusHyphae

(2008) Gregory A. Lamaris et al.   JOURNAL OF INFECTIOUS DISEASES

Differential High-Affinity Interaction of Dectin-1 with Natural or Synthetic Glucans Is Dependent upon Primary Structure and Is Influenced by Polymer Chain Length and Side-Chain Branching

(2008) E. L. Adams et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei

(2008) K NAKAMURA et al.   MICROBES AND INFECTION

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Dynamic, Morphotype-Specific Candida albicans β-Glucan Exposure during Infection and Drug Treatment

(2008) Robert T. Wheeler et al.   PLoS Pathogens

An integrated model of the recognition of Candida albicans by the innate immune system

(2007) Mihai G. Netea et al.   NATURE REVIEWS MICROBIOLOGY

C-type lectin receptors in antifungal immunity

(2007) Janet A. Willment et al.   TRENDS IN MICROBIOLOGY