Review
Pharmacology & Pharmacy
Thanut Khuayjarernpanishk, Sontaya Sookying, Acharaporn Duangjai, Surasak Saokaew, Asawadech Sanbua, Orapa Bunteong, Nutnicha Rungruangsri, Witchuda Suepsai, Patinya Sodsai, Jiraporn Soylaiad, Varintorn Nacharoen, Suwanna Noidamnoen, Pochamana Phisalprapa
Summary: Cancers are a major global cause of death and a significant burden on healthcare systems. Developing cancer prevention and treatment measures is crucial. P. odoratum, a plant with various pharmacological activities, has been found to have anticancer effects. This systematic review examined the activities of P. odoratum against different cancer cell lines and revealed its molecular mechanisms. The findings suggest that P. odoratum has promising potential as a chemotherapy and chemopreventive agent, but further research and clinical trials are needed to confirm its efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sheng-li Pei, Fang Kan, Chun-jiang Yue
Summary: The study showed that Morus alba extract has significant antihypertensive effects in renovascular hypertensive rats, possibly through inhibiting endothelin-converting enzyme and exerting antioxidant activity. Additionally, it significantly improved renal function in the rats.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Supannika Kawvised, Thawatchai Prabsattroo, Waranon Munkong, Panuwat Pattum, Sittichai Iamsaard, Kanokporn Boonsirichai, Pimporn Uttayarat, Lamai Maikaeo, Waraporn Sudchai, Woranan Kirisattayakul
Summary: This study investigated the effects of Polygonum odoratum leaf extract (POE) on oxidative stress and cell death induced by low dose ionizing radiation (LDIR) in Raw 264.7 cells. POE was found to be a potent antioxidant, reducing MDA levels and enhancing cell viability and antioxidant enzyme activities. The results suggest that POE could potentially be developed as a radioprotector for diagnostic procedures in the future.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Plant Sciences
Yahui Xuan, Bi Ma, Dong Li, Yu Tian, Qiwei Zeng, Ningjia He
Summary: This study analyzed the genome of wild mulberry species M. notabilis, revealing the chromosomal synteny and restructuring process between wild and cultivated mulberry. The activity of the centromere was found to be crucial for stable chromosome inheritance. Long terminal repeat retrotransposons were identified as the major driver of mulberry genome divergence and evolution after divergence.
HORTICULTURE RESEARCH
(2022)
Article
Food Science & Technology
Hao Cui, Yao Dong, Tenghui Lu, Xintong Zou, Mingxin Wang, Xiudong Yang, Hongli Zhou
Summary: The study demonstrated that ethanolic extract from Morus alba L. leaves (MLEE) shows promising potential in extending the shelf life of chilled pork while maintaining sensory characteristics.
Article
Medicine, Research & Experimental
Anna Gryn-Rynko, Iga Holynska-Iwan, Michal Adam Janiak, Dorota Olszewska-Slonina, Ryszard Amarowicz, Radomir Graczyk
Summary: Morus alba L., a herbal plant with therapeutic properties, has been found to affect ion channels in rabbit colon epithelium, leading to changes in electrical potential. This study provides valuable insights into the pharmacological effects of white mulberry leaves.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Lu Yang, Jiuyang Zhao, Shaoli Fan, Jinfa Liao, Yicun Chen, Yangdong Wang
Summary: Mulberry leaves collected after frost have superior medicinal properties. This study conducted metabolic profiling analyses on two types of mulberry leaves harvested at different times and identified over 100 compounds. The results showed that frost had different effects on the accumulation of metabolites in Morus nigra L. and Morus alba L., and picking time also influenced the levels of DNJ alkaloids and flavonoids in mulberry leaves.
Review
Food Science & Technology
Bo-Yoon Chang, Bong-Seong Koo, Sung-Yeon Kim
Summary: Extracts from Morus alba L. obtained through ethanol or methanol extraction contain phenols and flavonoids effective for immunosuppression, antioxidants, and cardiovascular diseases. Water extracts enhance innate immune response and induce pro-inflammatory substances through TLR4, thus showing potential in pathogen defense and tumor suppression. White Mulberry-derived pharmaceuticals have promising applications in future medical research.
Article
Pharmacology & Pharmacy
Jiyu Hyun, Jisoo Im, Sung-Won Kim, Han Young Kim, Inwoo Seo, Suk Ho Bhang
Summary: The use of Morus alba root extract promotes hair growth by activating beta-catenin in hair follicle dermal papilla cells, leading to the induction of the anagen phase. Additionally, the extract enhances growth factor secretion and shows no cytotoxic effects on the cells. Overall, Morus alba root extract demonstrates potential in transitioning hair follicles from the telogen phase to the anagen phase.
Article
Nutrition & Dietetics
Tae Sik Sung, Seung-Bum Ryoo, Chang-Hyun Lee, Seon-Min Choi, Joo-Won Nam, Hyun-Bok Kim, Ji Young Lee, Jung-Dae Lim, Kyu Joo Park, Hyun-Tai Lee
Summary: The fruit of Morus alba L. (MAF) has been used as a food worldwide and in traditional medicine in East Asia for thousands of years. This study found that MAF has prokinetic activity and can enhance gastrointestinal motor function in mice and human intestines. It increased both myogenic and neurogenic contractions, resulting in accelerated intestinal transit rate (ITR). These findings suggest that MAF has potential as a new prokinetic agent.
Article
Multidisciplinary Sciences
Agnieszka Bilska
Summary: The study found that the addition of mulberry leaf extract can delay fat oxidation in meat products, enhance their antioxidant activity and inhibitory enzyme activity. After adding mulberry leaf extract in simulated liver pates, the products maintained high sensory quality and unchanged microbiological quality during storage.
Article
Biochemistry & Molecular Biology
Tipaporn Kumkoon, Monrudee Srisaisap, Panadda Boonserm
Summary: In this study, silver nanoparticles were synthesized using white mulberry leaf extract and their antibacterial and anticancer potential was assessed. The nanoparticles showed excellent antibacterial activity against Acinetobacter baumannii strains, as well as good activity against other bacteria. They also demonstrated promising anticancer potential against MCF-7 cells, with no effect on normal cells.
Article
Biochemistry & Molecular Biology
Nittaya Chansiw, Sorraya Champakam, Pattranuch Chusri, Kanjana Pangjit, Somdet Srichairatanakool
Summary: The ethanolic extract of P. odoratum var. Pakphai, rich in quercetin and other compounds, was found to exhibit anti-inflammatory activity by inhibiting the production of nitric oxide and inflammatory mediators in LPS-induced RAW264.7 cells.
Article
Green & Sustainable Science & Technology
Ahmet Can, Ahmet Kazankaya, Erdal Orman, Muttalip Gundogdu, Sezai Ercisli, Ravish Choudhary, Rohini Karunakaran
Summary: This study analyzed 55 wild-grown mulberry landraces in the Van Lake basin, belonging to Morus alba, Morus rubra, and Morus nigra species, to determine their fruit characteristics. The research found that chlorogenic acid and rutin were the predominant compounds in all mulberry landraces. Malic acid was identified as the dominant organic acid among genotypes. These findings suggest that these mulberry landraces could be valuable for breeding purposes and may have potential health benefits due to their rich bioactive compounds.
Article
Food Science & Technology
Yan Xu, Yiqun Cheng, Zongshuai Zhu, Haoyu Guo, Anthony Pius Bassey, Tianran Huang, Yongqiang Huang, Ming Huang
Summary: The effect of different levels of mulberry leaf extract on the formation of heterocyclic amines in pan-fried duck patties was investigated. The results showed that 0.03% of the extract had the strongest inhibitory effect on heterocyclic amine formation and also inhibited lipid and protein oxidation. LC-MS analysis identified 15 phenolic compounds that may contribute to the mitigation of heterocyclic amine formation and oxidation.
Article
Cell Biology
Jintanaporn Wattanathorn, Paphaphat Thiraphatthanavong, Wipawee Thukham-mee, Supaporn Muchimapura, Panakaporn Wannanond, Terdthai Tong-un
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Article
Biotechnology & Applied Microbiology
Jintanaporn Wattanathorn, Wipawee Thukham-mee, Supaporn Muchimapura, Panakaporn Wannanon, Terdthai Tong-un, Somsak Tiamkao
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Biotechnology & Applied Microbiology
Chonlathip Thipkaew, Jintanaporn Wattanathorn, Supaporn Muchimapura
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Integrative & Complementary Medicine
Parichat On-ong-arj, Jintanaporn Wattanathorn, Supaporn Muchimapura, Wipawee Thukham-mee
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Article
Cell Biology
Jintanaporn Wattanathorn, Woraluk Somboonporn, Sudarat Sungkamanee, Wipawee Thukummee, Supaporn Muchimapura
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Biotechnology & Applied Microbiology
Jintanaporn Wattanathorn, Thawatchai Prabsattroo, Pichet Somsapt, Opass Sritragool, Wipawee Thukham-mee, Supaporn Muchimapura
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Cell Biology
Warhi Ohnon, Jintanaporn Wattanathorn, Wipawee Thukham-mee, Supaporn Muchimapura, Panakaporn Wannanon, Terdthai Tong-un
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Biotechnology & Applied Microbiology
Jintanaporn Wattanathorn, Panakaporn Wannanon, Supaporn Muchimapura, Wipawee Thukham-Mee, Terdthai Tong-Un, Pontapan Polyiam
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Cell Biology
Nut Palachai, Jintanaporn Wattanathorn, Supaporn Muchimapura, Wipawee Thukham-mee
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Cell Biology
Jintanaporn Wattanathorn, Warin Ohnon, Wipawee Thukhammee, Supaporn Muchmapura, Panakaporn Wannanon, Terdthai Tong-un
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Cell Biology
Nut Palachai, Jintanaporn Wattanathorn, Supaporn Muchimapura, Wipawee Thukham-mee
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Cell Biology
Jintanaporn Wattanathorn, Nut Palachai, Wipawee Thukham-mee, Supaporn Muchimapura
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Correction
Integrative & Complementary Medicine
Jintanaporn Wattanathorn, Jinatta Jittiwat, Terdthai Tongun, Supaporn Muchimapura, Kornkanok Ingkaninan
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Pratthana Srichomphu, Jintanaporn Wattanathorn, Wipawee Thukham-mee, Supaporn Muchimapura
Summary: This study found that the novel functional ingredients from Anacardium occidentale (AO) can alleviate psychological disorders that coexist with MetS in rats, including anxiety, insomnia, and memory impairment. AO exerts its protective effect by improving oxidative stress and the functions of the cholinergic and GABAergic systems.
