Panel 6

Comparative analyses of the Moraxella catarrhalis type-IV pilus structural subunit PilA

(2011) Nicole R. Luke-Marshall et al.   GENE

Investigating the potential of conserved inner core oligosaccharide regions of Moraxella catarrhalis lipopolysaccharide as vaccine antigens: accessibility and functional activity of monoclonal antibodies and glycoconjugate derived sera

(2011) Andrew D. Cox et al.   GLYCOCONJUGATE JOURNAL

Haemophilus influenzaevaccine candidate outer membrane protein P6 is not conserved in all strains

(2011) Arthur Chang et al.   Human vaccines & immunotherapeutics

Expression of the Type 1 Pneumococcal Pilus Is Bistable and Negatively Regulated by the Structural Component RrgA

(2011) Alan Basset et al.   INFECTION AND IMMUNITY

Long-term follow-up of chronic suppurative otitis media in a high-risk children cohort

(2011) Ramon Gordon Jensen et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Structure-guided Antigen Engineering Yields Pneumolysin Mutants Suitable for Vaccination against Pneumococcal Disease

(2011) Eliud O. Oloo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune Evasion of Moraxella catarrhalis Involves Ubiquitous Surface Protein A-Dependent C3d Binding

(2011) T. Hallstrom et al.   JOURNAL OF IMMUNOLOGY

Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae

(2011) L A Novotny et al.   Mucosal Immunology

Combined protective effects of anti-PhtD and anti-pneumococcal polysaccharides

(2011) Philippe Denoël et al.   VACCINE

Mutant lipooligosaccharide-based conjugate vaccine demonstrates a broad-spectrum effectiveness against Moraxella catarrhalis

(2011) Dabin Ren et al.   VACCINE

Nasal immunization with plasmid DNA encoding P6 protein and immunostimulatory complexes elicits nontypeable Haemophilus influenzae-specific long-term mucosal immune responses in the nasopharynx

(2011) Satoru Kodama et al.   VACCINE

Vaccine candidate P6 of nontypable Haemophilus influenzae is not a transmembrane protein based on protein structural analysis

(2011) Lea Vacca Michel et al.   VACCINE

Selection of family 1 PspA molecules capable of inducing broad-ranging cross-reactivity by complement deposition and opsonophagocytosis by murine peritoneal cells

(2011) Cibelly Goulart et al.   VACCINE

Construction and Immunogenicity of Recombinant Adenovirus Vaccines Expressing the HMW1, HMW2, or Hia Adhesion Protein of Nontypeable Haemophilus influenzae

(2010) L. E. Winter et al.   Clinical and Vaccine Immunology

Options for Inactivation, Adjuvant, and Route of Topical Administration of a Killed, Unencapsulated Pneumococcal Whole-Cell Vaccine

(2010) Y.-J. Lu et al.   Clinical and Vaccine Immunology

Immunization with a ZmpB-Based Protein Vaccine Could Protect against Pneumococcal Diseases in Mice

(2010) Yi Gong et al.   INFECTION AND IMMUNITY

Characterization and Evaluation of theMoraxella catarrhalisOligopeptide Permease A as a Mucosal Vaccine Antigen

(2010) Min Yang et al.   INFECTION AND IMMUNITY

Immune Responses to Recombinant Pneumococcal PsaA Antigen Delivered by a Live Attenuated Salmonella Vaccine

(2010) S. Wang et al.   INFECTION AND IMMUNITY

Immunization withSalmonella entericaSerovar Typhimurium-Derived Outer Membrane Vesicles Delivering the Pneumococcal Protein PspA Confers Protection against Challenge withStreptococcus pneumoniae

(2010) Maneesha Muralinath et al.   INFECTION AND IMMUNITY

Preclinical Evaluation of the Pht Proteins as Potential Cross-Protective Pneumococcal Vaccine Antigens

(2010) Fabrice Godfroid et al.   INFECTION AND IMMUNITY

The Proline-Rich Region of Pneumococcal Surface Proteins A and C Contains Surface-Accessible Epitopes Common to All Pneumococci and Elicits Antibody-Mediated Protection against Sepsis

(2010) C. C. Daniels et al.   INFECTION AND IMMUNITY

The Two Variants of the Streptococcus pneumoniae Pilus 1 RrgA Adhesin Retain the Same Function and Elicit Cross-Protection In Vivo

(2010) M. Moschioni et al.   INFECTION AND IMMUNITY

Protection against nasal colonization with Streptococcus pneumoniae by parenteral immunization with a DNA vaccine encoding PspA (Pneumococcal surface protein A)

(2010) Daniela M. Ferreira et al.   MICROBIAL PATHOGENESIS

Transcriptional regulation, occurrence and putative role of the Pht family of Streptococcus pneumoniae

(2010) S. Rioux et al.   MICROBIOLOGY-SGM

Vitronectin binds to the head region ofMoraxella catarrhalisubiquitous surface protein A2 and confers complement-inhibitory activity

(2010) Birendra Singh et al.   MOLECULAR MICROBIOLOGY

Recent Advances in Otitis Media

(2010) Stephen I. Pelton et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Chronic Suppurative Otitis Media in a Birth Cohort of Children in Greenland

(2010) Anders Koch et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Combination of Pneumococcal Surface Protein A (PspA) with Whole Cell Pertussis Vaccine Increases Protection Against Pneumococcal Challenge in Mice

(2010) Maria Leonor S. Oliveira et al.   PLoS One

Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae

(2010) Gill Douce et al.   VACCINE

A single nasal dose of fms-like tyrosine kinase receptor-3 ligand, but not peritoneal application, enhances nontypeable Haemophilus influenzae-specific long-term mucosal immune responses in the nasopharynx

(2010) Satoru Kodama et al.   VACCINE

Nasal vaccination with P6 outer membrane protein and α-galactosylceramide induces nontypeable Haemophilus influenzae-specific protective immunity associated with NKT cell activation and dendritic cell expansion in nasopharynx

(2010) Kenji Noda et al.   VACCINE

Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA

(2010) Gili Regev-Yochay et al.   VACCINE

Abrogation of nontypeable Haemophilus influenzae Protein D function reduces phosphorylcholine decoration, adherence to airway epithelial cells, and fitness in a chinchilla model of otitis media

(2010) Ryan W. Johnson et al.   VACCINE

Serum antibody response to three non-typeable Haemophilus influenzae outer membrane proteins during acute otitis media and nasopharyngeal colonization in otitis prone and non-otitis prone children

(2010) Ravinder Kaur et al.   VACCINE

The Pneumococcal Serine-Rich Repeat Protein Is an Intra-Species Bacterial Adhesin That Promotes Bacterial Aggregation In Vivo and in Biofilms

(2010) Carlos J. Sanchez et al.   PLoS Pathogens

Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species

(2010) Claudio Donati et al.   GENOME BIOLOGY

Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice

(2009) D. M. Ferreira et al.   Clinical and Vaccine Immunology

Antibodies Specific for the Hia Adhesion Proteins of Nontypeable Haemophilus influenzae Mediate Opsonophagocytic Activity

(2009) L. E. Winter et al.   Clinical and Vaccine Immunology

Identification of Domains of the Hag/MID Surface Protein Recognized by Systemic and Mucosal Antibodies in Adults with Chronic Obstructive Pulmonary Disease following Clearance of Moraxella catarrhalis

(2009) E. R. LaFontaine et al.   Clinical and Vaccine Immunology

Progress and Future Challenges in Coordinated Surveillance and Detection of Pneumococcal and Hib Disease in Developing Countries

(2009) Orin S. Levine et al.   CLINICAL INFECTIOUS DISEASES

Acute Otitis Media Caused byMoraxella catarrhalis:Epidemiologic and Clinical Characteristics

(2009) Arnon Broides et al.   CLINICAL INFECTIOUS DISEASES

Moraxella catarrhalis,a Human Respiratory Tract Pathogen

(2009) Timothy F. Murphy et al.   CLINICAL INFECTIOUS DISEASES

Peptide mimics of two pneumococcal capsular polysaccharide serotypes (6B and 9V) protect mice from a lethal challenge withStreptococcus pneumoniae

(2009) Claire M. Smith et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mucosal Immunization with Polyamine Transport Protein D (PotD) Protects Mice Against Nasopharyngeal Colonization with Streptococcus pneumoniae

(2009) Pratik Shah et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Vaccine development forMoraxella catarrhalis: rationale, approaches and challenges

(2009) Timothy F Murphy   Expert Review of Vaccines

Sortase A Confers Protection against Streptococcus pneumoniae in Mice

(2009) C. Gianfaldoni et al.   INFECTION AND IMMUNITY

Protection against Pneumococcal Colonization and Fatal Pneumonia by a Trivalent Conjugate of a Fusion Protein with the Cell Wall Polysaccharide

(2009) Y.-J. Lu et al.   INFECTION AND IMMUNITY

Identification of a Simple Chemical Structure Associated with Protective Human Antibodies against Multiple Pneumococcal Serogroups

(2009) S. Park et al.   INFECTION AND IMMUNITY

PspA Family Fusion Proteins Delivered by Attenuated Salmonella enterica Serovar Typhimurium Extend and Enhance Protection against Streptococcus pneumoniae

(2009) W. Xin et al.   INFECTION AND IMMUNITY

Hag Mediates Adherence of Moraxella catarrhalis to Ciliated Human Airway Cells

(2009) R. Balder et al.   INFECTION AND IMMUNITY

Immunization with a Combination of Three Pneumococcal Proteins Confers Additive and Broad Protection against Streptococcus pneumoniae Infections in Mice

(2009) K. Wu et al.   INFECTION AND IMMUNITY

Protection against nontypeable Haemophilus influenzae challenges by mucosal vaccination with a detoxified lipooligosaccharide conjugate in two chinchilla models

(2009) Wenzhou Hong et al.   MICROBES AND INFECTION

Acute and Chronic Otitis Media

(2009) Peter S. Morris et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Efficacy of Injectable Trivalent Virosomal-Adjuvanted Inactivated Influenza Vaccine in Preventing Acute Otitis Media in Children With Recurrent Complicated or Noncomplicated Acute Otitis Media

(2009) Paola Marchisio et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Efficacy and Safety of 1 and 2 Doses of Live Attenuated Influenza Vaccine in Vaccine-Naive Children

(2009) Humberto Bracco Neto et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Reduced Physician Claims for Otitis Media After Implementation of Pneumococcal Conjugate Vaccine Program in the Province of Quebec, Canada

(2009) Philippe De Wals et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Breast-Feeding Is Associated With a Reduced Frequency of Acute Otitis Media and High Serum Antibody Levels Against NTHi and Outer Membrane Protein Vaccine Antigen Candidate P6

(2009) Albert Sabirov et al.   PEDIATRIC RESEARCH

Continued Impact of Pneumococcal Conjugate Vaccine on Carriage in Young Children

(2009) S. S. Huang et al.   PEDIATRICS

Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis

(2009) Elizabeth A. Ruckdeschel et al.   VACCINE

Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates

(2009) Laura A. Novotny et al.   VACCINE

Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae-derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age

(2009) Roman Prymula et al.   VACCINE

Current progress withMoraxella catarrhalisantigens as vaccine candidates

(2008) Fatme Mawas et al.   Expert Review of Vaccines

Galactose Residues on the Lipooligosaccharide of Moraxella catarrhalis 26404 Form the Epitope Recognized by the Bactericidal Antiserum from Conjugate Vaccination

(2008) S. Yu et al.   INFECTION AND IMMUNITY

Pneumococcal Haemophilus influenzae Protein D Conjugate Vaccine Induces Antibodies That Inhibit Glycerophosphodiester Phosphodiesterase Activity of Protein D

(2008) M. Toropainen et al.   INFECTION AND IMMUNITY

Mining the Moraxella catarrhalis Genome: Identification of Potential Vaccine Antigens Expressed during Human Infection

(2008) E. A. Ruckdeschel et al.   INFECTION AND IMMUNITY

Streptococcus pneumoniae Surface Protein PcpA Elicits Protection against Lung Infection and Fatal Sepsis

(2008) D. T. Glover et al.   INFECTION AND IMMUNITY

Nasal Immunization with Lactococcus lactis Expressing the Pneumococcal Protective Protein A Induces Protective Immunity in Mice

(2008) M. Medina et al.   INFECTION AND IMMUNITY

Antibodies against PsrP, a NovelStreptococcus pneumoniaeAdhesin, Block Adhesion and Protect Mice against Pneumococcal Challenge

(2008) Lloyd Rose et al.   JOURNAL OF INFECTIOUS DISEASES

Streptococcus pneumoniaeContains 3rlrAPilus Variants That Are Clonally Related

(2008) Monica Moschioni et al.   JOURNAL OF INFECTIOUS DISEASES

Increase in the Prevalence of the Newly Discovered Pneumococcal Serotype 6C in the Nasopharynx after Introduction of Pneumococcal Conjugate Vaccine

(2008) Moon H. Nahm et al.   JOURNAL OF INFECTIOUS DISEASES

Current epidemiology of intracranial abscesses: a prospective 5 year study

(2008) S. Menon et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Recognition of pneumococcal isolates by antisera raised against PspA fragments from different clades

(2008) M. Darrieux et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Effects of Influenza Plus Pneumococcal Conjugate Vaccination Versus Influenza Vaccination Alone in Preventing Respiratory Tract Infections in Children: A Randomized, Double-Blind, Placebo-Controlled Trial

(2008) Angelique G.S.C. Jansen et al.   JOURNAL OF PEDIATRICS

Mucosal immunization with purified ClpP could elicit protective efficacy against pneumococcal pneumonia and sepsis in mice

(2008) Ju Cao et al.   MICROBES AND INFECTION

Nasal immunization of mice with Lactobacillus casei expressing the Pneumococcal Surface Protein A: induction of antibodies, complement deposition and partial protection against Streptococcus pneumoniae challenge

(2008) Ivana B. Campos et al.   MICROBES AND INFECTION

Trends in Acute Otitis Media-Related Health Care Utilization by Privately Insured Young Children in the United States, 1997-2004

(2008) F. Zhou et al.   PEDIATRICS

Pneumococcal Mastoiditis in Children and the Emergence of Multidrug-Resistant Serotype 19A Isolates

(2008) J. Ongkasuwan et al.   PEDIATRICS

Protection induced by pneumococcal surface protein A (PspA) is enhanced by conjugation to a Streptococcus pneumoniae capsular polysaccharide

(2008) Fátima C.L. Csordas et al.   VACCINE