Journal
VACCINE
Volume 29, Issue 8, Pages 1624-1627Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.12.082
Keywords
Nontypable Haemophilus influenzae; P6 protein; Outer membrane protein
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Funding
- NIH NIDCD [RO1 08671]
- Rochester Institute of Technology
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P6 has been a vaccine candidate for nontypable Haemophilus influenzae (NTHi) based on its location on the outer membrane and immunogenicity. Because P6 is attached to the inner peptidoglycan layer of NTHi, and is putatively surface exposed, it must be a transmembrane protein. We examined the P6 structure using computational modeling, site-directed mutagenesis, and nuclear magnetic resonance spectroscopy. We found that P6 cannot be a transmembrane protein, and therefore may not be surface exposed. We conclude that there may be another protein on the surface of NTHi that has epitopes similar if not identical to P6. (C) 2011 Elsevier Ltd. All rights reserved.
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