Article
Infectious Diseases
Cornelis H. van Werkhoven, Marieke Bolkenbaas, Susanne M. Huijts, Theo J. M. Verheij, Marc J. M. Bonten
Summary: A study found that the 13-valent pneumococcal conjugate vaccine (PCV13) did not significantly reduce the incidence of community-acquired pneumonia (CAP) and lower respiratory tract infections (LRTI), as well as related antibiotic use, among immunocompetent adults over 65 years of age in primary care settings.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Cardiac & Cardiovascular Systems
Ole Frobert, Matthias Gotberg, David Erlinge, Zubair Akhtar, Evald H. Christiansen, Chandini R. MacIntyre, Keith G. Oldroyd, Zuzana Motovska, Andrejs Erglis, Rasmus Moer, Ota Hlinomaz, Lars Jakobsen, Thomas Engstrom, Lisette O. Jensen, Christian O. Fallesen, Svend E. Jensen, Oskar Angeras, Fredrik Calais, Amra Karegren, Jorg Lauermann, Arash Mokhtari, Johan Nilsson, Jonas Persson, Per Stalby, Abu K. M. M. Islam, Afzalur Rahman, Fazila Malik, Sohel Choudhury, Timothy Collier, Stuart J. Pocock, John Pernow
Summary: This study found that early influenza vaccination after myocardial infarction or in patients with high-risk coronary heart disease significantly reduced the risk of death, myocardial infarction, or stent thrombosis, and also decreased the risk of all-cause death and cardiovascular death within 12 months compared to placebo.
Article
Multidisciplinary Sciences
Yeon Haw Jung, Yong June Choe, Chae Young Lee, Sang Oun Jung, Dong Han Lee, Jae Il Yoo
Summary: This study describes the epidemiology of invasive pneumococcal disease (IPD) in South Korea and highlights the changes in serotypes following the introduction of pneumococcal conjugate vaccines. The findings suggest the need for continued monitoring during the development of new vaccines.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Richard L. Sheer, David P. Nau, Nicholas Dorich, Jesse McCullough, Annette D. Boyer, Matthew Pickering, Patrick J. Campbell, Margaret K. Pasquale
Summary: The study revealed that a collaborative effort between a Medicare Advantage and prescription drug plan and community pharmacies can effectively improve vaccination rates for pneumonia and influenza among older adults. The intervention group showed significantly higher odds of delivering pneumonia and influenza vaccinations compared to the control group, particularly in influenza vaccination.
AMERICAN JOURNAL OF MANAGED CARE
(2021)
Article
Medicine, General & Internal
Robin Kate Kelley, Makoto Ueno, Changhoon Yoo, Richard S. Finn, Junji Furuse, Zhenggang Ren, Thomas Yau, Heinz-Josef Klumpen, Stephen L. Chan, Masato Ozaka, Chris Verslype, Mohamed Bouattour, Joon Oh Park, Olga Barajas, Uwe Pelzer, Juan W. Valle, Li Yu, Usha Malhotra, Abby B. Siegel, Julien Edeline, Arndt Vogel
Summary: This study examined the efficacy of adding the immune checkpoint inhibitor pembrolizumab to the standard chemotherapy regimen for advanced biliary tract cancer. The results showed that the combination treatment significantly improved overall survival compared to chemotherapy alone.
Article
Nursing
Joseph Walter, Nicole Rudawsky
Summary: This article reviews the updated pneumococcal vaccine recommendations from the Centers for Disease Control and Prevention, including two new vaccines, and discusses their advantages, disadvantages, and nursing implications.
AMERICAN JOURNAL OF NURSING
(2023)
Article
Pediatrics
Julia G. Harris, Luke A. Harris, Liset Olarte, E. Claire Elson, Rachel Moran, Douglas L. Blowey, Rana E. El Feghaly
Summary: This project aimed to improve PPSV23 vaccination rates for pediatric patients at high risk for invasive pneumococcal disease (IPD) through several initiatives and practices. The results showed an increase in vaccination rate from approximately 20% to approximately 60%. This suggests that using quality improvement methodology can enhance vaccination rates and achieve sustained and comprehensive improvements across different divisions.
Article
Immunology
Lindsay R. Grant, Mary P. E. Slack, Christian Theilacker, Jelena Vojicic, Stephane Dion, Ralf Rene Reinert, Luis Jodar, Bradford D. Gessner
Summary: The distribution of pneumococcal serotypes in children from high-income countries has been examined. Much of the burden of invasive pneumococcal disease (IPD) is caused by serotypes in PCV15 and PCV20; including these pneumococcal conjugate vaccines (PCVs) into existing pediatric immunization programs may help reduce the incidence of IPD.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Pharmacology & Pharmacy
Claudine El-Beyrouty, Rebecca Buckler, Meghan Mitchell, Samantha Phillips, Sara Groome
Summary: Streptococcus pneumoniae remains a significant pathogen causing both mild and severe infections, and the development of vaccines and improved vaccination rates have greatly reduced mortality.
Article
Immunology
Ivan Martinez-Baz, Ana Navascues, Maria Eugenia Portillo, Itziar Casado, Ujue Fresan, Carmen Ezpeleta, Jesus Castilla
Summary: The study estimated the average effect of influenza vaccination on preventing laboratory-confirmed influenza hospitalization in diabetic patients, showing that influenza vaccination can significantly reduce the probability of hospitalization for diabetic patients and that vaccination in prior seasons also maintained a notable protective effect.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Deus Thindwa, Samuel Clifford, Jackie Kleynhans, Anne von Gottberg, Sibongile Walaza, Susan Meiring, Todd D. Swarthout, Elizabeth Miller, Peter McIntyre, Nick Andrews, Zahin Amin-Chowdhury, Norman Fry, Kondwani C. Jambo, Neil French, Samanta Cristine Grassi Almeida, Shamez N. Ladhani, Robert S. Heyderman, Cheryl Cohen, Maria Cristina de Cunto Brandileone, Stefan Flasche
Summary: The risk of invasive pneumococcal disease (IPD) increases with age for older adults, but the population benefiting from pneumococcal vaccines and the immunogenic response to vaccination decline. This study examined the impact of demographics, vaccine efficacy, and waning efficacy on the optimal age for pneumococcal vaccination. The findings suggest that administering pneumococcal vaccines earlier in adulthood in low/middle-income countries could prevent a significant proportion of residual IPD burden.
NATURE COMMUNICATIONS
(2023)
Article
Respiratory System
Kay Wang, Malcolm G. Semple, Michael Moore, Alastair D. Hay, Sharon Tonner, Ushma Galal, Jenna Grabey, Tricia Carver, Rafael Perera, Ly-Mee Yu, Jill Mollison, Paul Little, Andrew Farmer, Christopher C. Butler, Anthony Harnden
Summary: This pragmatic trial found that early use of co-amoxiclav did not reduce the risk of reconsultation due to clinical deterioration in at risk children during the influenza season. The findings do not support the use of early co-amoxiclav in children with seasonal ILI.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Ivan Martinez-Baz, Itziar Casado, Ana Navascues, Maria Eugenia Portillo, Marcela Guevara, Carmen Ezpeleta, Jesus Castilla
Summary: Evidence shows that influenza vaccination has a moderate effect in preventing laboratory-confirmed influenza among COPD patients. Current-season vaccination has a higher average effect compared to prior-season vaccination. The preventive effect seems to be stronger for outpatient cases. There is no significant difference in vaccination effect between COPD and non-COPD target populations.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Craig D. Nielsen, Joel A. Kammeyer, Michael J. Tan
Summary: The recommendations for pneumococcal vaccination in adults have been updated to prevent more cases of invasive pneumococcal disease and to make the recommendations simpler and easier to follow.
CLEVELAND CLINIC JOURNAL OF MEDICINE
(2022)
Article
Immunology
Kathryn J. Britton, Janessa L. Pickering, William S. Pomat, Camilla de Gier, Monica L. Nation, Casey L. Pell, Caitlyn M. Granland, Vela Solomon, Rebecca L. Ford, Andrew Greenhill, Jason Hinds, Hannah C. Moore, Peter C. Richmond, Christopher C. Blyth, Deborah Lehmann, Catherine Satzke, Lea-Ann S. Kirkham
Summary: The study found that in Papua New Guinea, PCV13 had no impact on pneumococcal carriage density, even for vaccine serotypes. The low prevalence of vaccine serotypes, high pneumococcal carriage density, and abundance of non-vaccine serotypes likely contribute to the lack of PCV13 impact on carriage in Papua New Guinean infants.
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)