Use ofIn VitroMorphogenesis of Mouse Embryoid Bodies to Assess Developmental Toxicity of Therapeutic Drugs Contraindicated in Pregnancy

Use of the ES-D3 cell differentiation assay, combined with the BeWo transport model, to predict relative in vivo developmental toxicity of antifungal compounds

(2015) Hequn Li et al.   TOXICOLOGY IN VITRO

A method for human teratogen detection by geometrically confined cell differentiation and migration

(2015) Jiangwa Xing et al.   Scientific Reports

Exposure-Based Validation List for Developmental Toxicity Screening Assays

(2014) George P. Daston et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells

(2014) S. C. van den Brink et al.   DEVELOPMENT

Prenatal diethylstilbestrol induces malformation of the external genitalia of male and female mice and persistent second-generation developmental abnormalities of the external genitalia in two mouse strains

(2014) Phitsanu Mahawong et al.   DIFFERENTIATION

Antihistamines and birth defects: a systematic review of the literature

(2014) Suzanne M Gilboa et al.   Expert Opinion On Drug Safety

An overview of current and emerging SERMs

(2014) Barry S. Komm et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Unique Pharmacological Characteristics of Mifepristone (RU486): From Terminating Pregnancy to Preventing Cancer Metastasis

(2014) Jianzhong Chen et al.   MEDICINAL RESEARCH REVIEWS

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil

(2014) Caroline G.Y. Lau et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

FDA Approval of Doxylamine–Pyridoxine Therapy for Use in Pregnancy

(2014) Shelley R. Slaughter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptomic Characterization of C57BL/6 Mouse Embryonic Stem Cell Differentiation and Its Modulation by Developmental Toxicants

(2014) Xiugong Gao et al.   PLoS One

Exposure to diethylstilbestrol during sensitive life stages: A legacy of heritable health effects

(2013) Casey E. Reed et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Metoclopramide in Pregnancy and Risk of Major Congenital Malformations and Fetal Death

(2013) Björn Pasternak et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antiobesity drugs in early pregnancy and congenital malformations in the offspring

(2013) Bengt A.J. Källén   Obesity Research & Clinical Practice

Update on Raloxifene

(2013) Salvatore Gizzo et al.   OBSTETRICAL & GYNECOLOGICAL SURVEY

A High-Throughput Screen for Teratogens Using Human Pluripotent Stem Cells

(2013) Sei Kameoka et al.   TOXICOLOGICAL SCIENCES

The DNT-EST: A predictive embryonic stem cell-based assay for developmental neurotoxicity testing in vitro

(2013) Katrin Hayess et al.   TOXICOLOGY

Pharmacokinetic Dose Proportionality Between Two Strengths (12.5 mg and 25 mg) of Doxylamine Hydrogen Succinate Film-Coated Tablets in Fasting State: A Single-Dose, Randomized, Two-Period Crossover Study in Healthy Volunteers

(2013) Sebastián Videla et al.   Drugs in research & development

Teratogenic Risk of Statins in Pregnancy

(2012) Laura M Godfrey et al.   ANNALS OF PHARMACOTHERAPY

Assaying embryotoxicity in the test tube: Current limitations of the embryonic stem cell test (EST) challenging its applicability domain

(2012) Christian Riebeling et al.   CRITICAL REVIEWS IN TOXICOLOGY

Convergent extension: using collective cell migration and cell intercalation to shape embryos

(2012) M. Tada et al.   DEVELOPMENT

Dihydroergotamine (DHE) Use During Gestation and the Risk of Adverse Pregnancy Outcomes

(2012) Anick Bérard et al.   HEADACHE

Hedgehog Signaling Regulates MyoD Expression and Activity

(2012) Anastassia Voronova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Establishment of a Molecular Embryonic Stem Cell Developmental Toxicity Assay

(2012) Julieta M. Panzica-Kelly et al.   TOXICOLOGICAL SCIENCES

Osteoblast differentiation of murine embryonic stem cells as a model to study the embryotoxic effect of compounds

(2012) Esther de Jong et al.   TOXICOLOGY IN VITRO

Laboratory models and their role in assessing teratogenesis

(2011) George P. Daston   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Behavioral characterization of cereblon forebrain-specific conditional null mice: A model for human non-syndromic intellectual disability

(2011) Anjali M. Rajadhyaksha et al.   BEHAVIOURAL BRAIN RESEARCH

Mutations in ZIC3 and ACVR2B are a common cause of heterotaxy and associated cardiovascular anomalies

(2011) Lijiang Ma et al.   CARDIOLOGY IN THE YOUNG

Deciphering the mystery of thalidomide teratogenicity

(2011) Takumi Ito et al.   CONGENITAL ANOMALIES

The validated embryonic stem cell test to predict embryotoxicity in vitro

(2011) Andrea E M Seiler et al.   Nature Protocols

The embryonic stem cell test combined with toxicogenomics as an alternative testing model for the assessment of developmental toxicity

(2011) Dorien A.M. van Dartel et al.   REPRODUCTIVE TOXICOLOGY

Evaluation of Novel High-Throughput Embryonic Stem Cell Tests with New Molecular Markers for Screening Embryotoxic Chemicals In Vitro

(2011) Noriyuki Suzuki et al.   TOXICOLOGICAL SCIENCES

Fetotoxicity of warfarin anticoagulation

(2010) Sumit Mehndiratta et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

The Ribavirin Pregnancy Registry: Findings after 5 years of enrollment, 2003-2009

(2010) Susan S. Roberts et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006

(2010) Samantha E. Parker et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

A different approach to validating screening assays for developmental toxicity

(2010) George P. Daston et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

From alternative methods to a new toxicology

(2010) Thomas Hartung   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Teratogenicity and underlying mechanisms of homocysteine in animal models: A review

(2010) Nina H. van Mil et al.   REPRODUCTIVE TOXICOLOGY

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

Amiodarone and thyroid

(2009) Silvia A. Eskes et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Thalidomide-induced limb defects: resolving a 50-year-old puzzle

(2009) Neil Vargesson   BIOESSAYS

Big risks in small groups: The difference between epidemiology and counselling

(2009) J. M. Friedman   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Aggregated P19 mouse embryonal carcinoma cells as a simple in vitro model to study the molecular regulations of mesoderm formation and axial elongation morphogenesis

(2009) Yusuke Marikawa et al.   GENESIS

Congenital Duplication of the Palm Syndrome: Gene Analysis and the Molecular Basis of its Clinical Features

(2009) M. M. AL-QATTAN et al.   Journal of Hand Surgery-European Volume

Chemical regulators have overreached

(2009) Thomas Hartung et al.   NATURE

Embryonic Stem Cell Test Remastered: Comparison between the Validated EST and the New Molecular FACS-EST for Assessing Developmental Toxicity In Vitro

(2009) Roland Buesen et al.   TOXICOLOGICAL SCIENCES

Möbius Syndrome in a Neonate After Mifepristone and Misoprostol Elective Abortion Failure

(2008) Marie-Andrée Bos-Thompson et al.   ANNALS OF PHARMACOTHERAPY

Pluripotent stem cell lines

(2008) J. Yu et al.   GENES & DEVELOPMENT