The Unique Pharmacological Characteristics of Mifepristone (RU486): From Terminating Pregnancy to Preventing Cancer Metastasis

Synthesis, Spectral Characterization, and In Vitro Cellular Activities of Metapristone, a Potential Cancer Metastatic Chemopreventive Agent Derived from Mifepristone (RU486)

(2014) Jichuang Wang et al.   AAPS Journal

Cytostasis and morphological changes induced by mifepristone in human metastatic cancer cells involve cytoskeletal filamentous actin reorganization and impairment of cell adhesion dynamics

(2013) BreeAnn N Brandhagen et al.   BMC CANCER

Mifepristone improves chemo-radiation response in glioblastoma xenografts

(2013) Monserrat Llaguno-Munive et al.   Cancer Cell International

Glucocorticoid Receptor Antagonism as a Novel Therapy for Triple-Negative Breast Cancer

(2013) M. N. Skor et al.   CLINICAL CANCER RESEARCH

Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy

(2012) Carlos D Gamarra-Luques et al.   BMC CANCER

Treatment of uterine myoma with 5 or 10mg mifepristone daily during 6 months, post-treatment evolution over 12 months: double-blind randomised clinical trial

(2012) Josep Ll. Carbonell Esteve et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

A study of mifepristone/IFN-γ-induced apoptosis of human cholangiocarcinoma cell line FRH-0201 in vitro

(2012) Qi-long Sun et al.   OncoTargets and Therapy

Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression

(2011) Chelsea R Tieszen et al.   BMC CANCER

Study of effectiveness of mifepristone for glioma cell line growth suppression

(2011) Raghu Ramaswamy et al.   BRITISH JOURNAL OF NEUROSURGERY

Compilation of 222 drugs’ plasma protein binding data and guidance for study designs

(2011) Fengling Zhang et al.   DRUG DISCOVERY TODAY

Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2

(2011) Alicia A. Goyeneche et al.   INVESTIGATIONAL NEW DRUGS

Mifepristone: pharmacology and clinical impact in reproductive medicine, endocrinology and oncology

(2010) Annie Im et al.   EXPERT OPINION ON PHARMACOTHERAPY

Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the sentinel lymph nodes of mice

(2010) Claudia Gabaglia et al.   Journal of Translational Medicine

Phase 2 trial of mifepristone (RU-486) in advanced or recurrent endometrioid adenocarcinoma or low-grade endometrial stromal sarcoma

(2009) Lois M. Ramondetta et al.   CANCER

Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicity

(2009) Elizabeth M Freeburg et al.   Cancer Cell International

Mifepristone: ten years later

(2009) Eric A. Schaff   CONTRACEPTION

Clinical utility of progesterone receptor modulators and their effect on the endometrium

(2009) Irving M Spitz   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

A phase II evaluation of mifepristone in the treatment of recurrent or persistent epithelial ovarian, fallopian or primary peritoneal cancer: A gynecologic oncology group study

(2009) Thomas F. Rocereto et al.   GYNECOLOGIC ONCOLOGY

Paradoxical Stimulation of Cyclooxygenase-2 Expression by Glucocorticoids via a Cyclic AMP Response Element in Human Amnion Fibroblasts

(2009) X. O. Zhu et al.   MOLECULAR ENDOCRINOLOGY

Simultaneous determination of mifepristone and monodemethyl-mifepristone in human plasma by liquid chromatography-tandem mass spectrometry method using levonorgestrel as an internal standard: application to a pharmacokinetic study

(2008) Cheng Tang et al.   BIOMEDICAL CHROMATOGRAPHY

A phase II study of mifepristone (RU-486) in castration-resistant prostate cancer, with a correlative assessment of androgen-related hormones

(2008) Mary-Ellen Taplin et al.   BJU INTERNATIONAL

The effect of mifepristone on breast cell proliferation in premenopausal women evaluated through fine needle aspiration cytology

(2008) M. Engman et al.   HUMAN REPRODUCTION

Global gene expression profiling of progesterone receptor modulators in T47D cells provides a new classification system

(2008) Wiebke Afhüppe et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: Absence of toxicity due to saturating absorption

(2007) Lee Jia et al.   FOOD AND CHEMICAL TOXICOLOGY