Gamma-secretase-dependent signaling of receptor tyrosine kinases

Irreversible modifications of receptor tyrosine kinases

(2018) Matthew Kreitman et al.   FEBS LETTERS

MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer

(2018) Ying Zhang et al.   Molecular Cancer

APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding

(2018) Linda Schauenburg et al.   Scientific Reports

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells

(2017) Yinzhong Lu et al.   FASEB JOURNAL

SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase

(2017) Anna M. Knittle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis

(2017) Ryo Iwamoto et al.   JOURNAL OF CELL SCIENCE

Genome-wide screen of gamma-secretase–mediated intramembrane cleavage of receptor tyrosine kinases

(2017) Johannes A. M. Merilahti et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

(2017) Adam Graham Grieve et al.   eLife

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer

(2016) Miles A. Miller et al.   CLINICAL CANCER RESEARCH

Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE

(2016) Jacob J. Orme et al.   CLINICAL IMMUNOLOGY

Substrate recruitment of γ‐secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping

(2016) Akio Fukumori et al.   EMBO JOURNAL

Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments

(2016) Xavier Meckler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity activation of metalloproteinases and γ-secretases

(2016) Gonzalo S Tejeda et al.   JOURNAL OF PATHOLOGY

Membranome: a database for proteome-wide analysis of single-pass membrane proteins

(2016) Andrei L. Lomize et al.   NUCLEIC ACIDS RESEARCH

TMSEG: Novel prediction of transmembrane helices

(2016) Michael Bernhofer et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Phosphatidylserine exposure is required for ADAM17 sheddase function

(2016) Anselm Sommer et al.   Nature Communications

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

(2016) M. A. Miller et al.   Cancer Discovery

Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity

(2015) Stefan Düsterhöft et al.   BIOCHEMISTRY

Intramembrane Proteolysis of β-Amyloid Precursor Protein by γ-Secretase Is an Unusually Slow Process

(2015) Frits Kamp et al.   BIOPHYSICAL JOURNAL

Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases

(2015) Mei-Kuang Chen et al.   FEBS Journal

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

(2015) Allen C. Chen et al.   JOURNAL OF CELL BIOLOGY

Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain

(2015) David M. Bolduc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation

(2015) Christoffer K. Goth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics

(2015) D. Langosch et al.   TRENDS IN BIOCHEMICAL SCIENCES

γ-secretase directly sheds the survival receptor BCMA from plasma cells

(2015) Sarah A. Laurent et al.   Nature Communications

Hypoxia-inducible Factor-1α Induces ErbB4 Signaling in the Differentiating Mammary Gland

(2014) Ilkka Paatero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibodies directed against receptor tyrosine kinases

(2014) Bénédicte FAUVEL et al.   mAbs

N-Terminal Cleavage and Release of the Ectodomain of Flt1 Is Mediated via ADAM10 and ADAM 17 and Regulated by VEGFR2 and the Flt1 Intracellular Domain

(2014) Nandita S. Raikwar et al.   PLoS One

ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer

(2014) Sandra Van Schaeybroeck et al.   Cell Reports

A Subset of Membrane-Altering Agents and γ-Secretase Modulators Provoke Nonsubstrate Cleavage by Rhomboid Proteases

(2014) Siniša Urban et al.   Cell Reports

γ-Secretase inhibitors and modulators

(2013) Todd E. Golde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

(2013) Nami Sugiyama et al.   JOURNAL OF CELL BIOLOGY

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase

(2013) Satoru Funamoto et al.   Nature Communications

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Protein Inhibitor of Activated STAT3 (PIAS3) Protein Promotes SUMOylation and Nuclear Sequestration of the Intracellular Domain of ErbB4 Protein

(2012) Maria Sundvall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cytosolic Domain of Protein-tyrosine Kinase 7 (PTK7), Generated from Sequential Cleavage by a Disintegrin and Metalloprotease 17 (ADAM17) and γ-Secretase, Enhances Cell Proliferation and Migration in Colon Cancer Cells

(2012) Hye-Won Na et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1α Signaling

(2012) Ilkka Paatero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Disintegrin and Metalloenzyme (ADAM) 17 Activation Is Regulated by α5β1 Integrin in Kidney Mesangial Cells

(2012) Pal Gooz et al.   PLoS One

Proteolytic Processing of ErbB4 in Breast Cancer

(2012) Maija Hollmén et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association

(2012) P. Xu et al.   Science Signaling

Neuregulin Receptor ErbB4 Functions as a Transcriptional Cofactor for the Expression of Surfactant Protein B in the Fetal Lung

(2011) Katja Zscheppang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Estrogen-induced upregulation of Sftpb requires transcriptional control of neuregulin receptor ErbB4 in mouse lung type II epithelial cells

(2011) Katja Zscheppang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

(2011) Edward Thorp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3

(2011) Catherine R. Degnin et al.   MOLECULAR BIOLOGY OF THE CELL

Tissue inhibitors of metalloproteinases

(2011) Gillian Murphy   GENOME BIOLOGY

Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation

(2010) Kristina Hoeing et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Disintegrin and Metalloproteinase-10 (ADAM-10) Mediates DN30 Antibody-induced Shedding of the Met Surface Receptor

(2010) Florian Schelter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM8 is a negative regulator of retinal neovascularization and of the growth of heterotopically injected tumor cells in mice

(2010) Victor H. Guaiquil et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cell Death or Survival Promoted by Alternative Isoforms of ErbB4

(2010) Maria Sundvall et al.   MOLECULAR BIOLOGY OF THE CELL

Interactions of ErbB4 and Kap1 Connect the Growth Factor and DNA Damage Response Pathways

(2010) Maureen Gilmore-Hebert et al.   MOLECULAR CANCER RESEARCH

Subcellular Localization of the HER4 Intracellular Domain, 4ICD, Identifies Distinct Prognostic Outcomes for Breast Cancer Patients

(2009) Ann D. Thor et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of Ligand-Induced Proteolytic Cleavage and Ectodomain Shedding of VEGFR-1/FLT1 in Leukemic Cancer Cells

(2009) N. Rahimi et al.   CANCER RESEARCH

Pigment Epithelium-derived Factor Maintains Retinal Pigment Epithelium Function by Inhibiting Vascular Endothelial Growth Factor-R2 Signaling through γ-Secretase

(2009) Zsolt Ablonczy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptide EphB2/CTF2 Generated by the γ-Secretase Processing of EphB2 Receptor Promotes Tyrosine Phosphorylation and Cell Surface Localization ofN-Methyl-d-aspartate Receptors

(2009) Jindong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation

(2009) Eiji Inoue et al.   JOURNAL OF CELL BIOLOGY

Down-Regulation of the Met Receptor Tyrosine Kinase by Presenilin-dependent Regulated Intramembrane Proteolysis

(2009) Bénédicte Foveau et al.   MOLECULAR BIOLOGY OF THE CELL

Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

(2009) Tomoko Wakabayashi et al.   NATURE CELL BIOLOGY

Proteolytic cleavages give receptor tyrosine kinases the gift of ubiquity

(2009) F Ancot et al.   ONCOGENE

Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms

(2009) M Hollmén et al.   ONCOGENE

VEGF-A Stimulates ADAM17-Dependent Shedding of VEGFR2 and Crosstalk Between VEGFR2 and ERK Signaling

(2008) Steven Swendeman et al.   CIRCULATION RESEARCH

Cleavage of the Wnt Receptor Ryk Regulates Neuronal Differentiation during Cortical Neurogenesis

(2008) Jungmook Lyu et al.   DEVELOPMENTAL CELL

Toll-like receptors stimulate regulated intramembrane proteolysis of the CSF-1 receptor through Erk activation

(2008) Gary Glenn et al.   FEBS LETTERS

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meltrin β/ADAM19 Interacting with EphA4 in Developing Neural Cells Participates in Formation of the Neuromuscular Junction

(2008) Norihiro Yumoto et al.   PLoS One

Regulation of the proteolytic disintegrin metalloproteinases, the ‘Sheddases’

(2008) Gillian Murphy   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

(2008) Matthew L Hemming et al.   PLOS BIOLOGY