Review
Biochemistry & Molecular Biology
Maria Consiglia Trotta, Carlo Gesualdo, Francesco Petrillo, Caterina Claudia Lepre, Alberto Della Corte, Giancuomo Cavasso, Giulia Maggiore, Anca Hermenean, Francesca Simonelli, Michele D'Amico, Settimio Rossi
Summary: This article discusses the importance of resolution of inflammation in preventing the progression of retinal damage and highlights the role of pro-resolving mediators in modulating inflammatory exudates, as well as potential drug targets in the treatment of retinal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Nusrath Yasmeen, Harikrishnan Selvaraj, Sudarshan S. Lakhawat, Manali Datta, Pushpender K. Sharma, Ajay Jain, Rakhi Khanna, Jayalakshmi Srinivasan, Vikram Kumar
Summary: Fatal cytokine storms (CS) observed in critically ill COVID-19 patients are consequences of dysregulated host immune system and over-exuberant inflammatory response. Efforts to save critical COVID-19 patients include using drugs like dexamethasone, remdesivir, hydroxychloroquine, etc. along with approved vaccines. Inflammation resolution, achieved through specialized pro-resolving mediators (SPMs) like Resolvins, lipoxins, maresins, protectins, could enhance the process of resolution and be useful in pain relief and tissue remodeling.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Undurti N. Das
Summary: Arachidonic acid (AA) metabolism plays a critical role in the initiation and resolution of inflammation. Prostaglandin E2 (PGE2) and lipoxin A4 (LXA4) interact in a regulatory manner during inflammation, aiding in inflammation resolution and tissue regeneration.
Review
Biochemistry & Molecular Biology
Mariarosaria Valente, Marta Dentoni, Fabrizio Bellizzi, Fedra Kuris, Gian Luigi Gigli
Summary: This article highlights the significance of specialized pro-resolving mediators (SPMs) in the inflammation environment and their role in neuroinflammation and major neurological diseases.
Review
Chemistry, Medicinal
Kevin Daly, Killian O'Sullivan, Timothy P. O'Sullivan
Summary: The structural modifications and activity relationships of resolvins, protectins, maresins, and their analogues, which are molecules involved in inflammation resolution, are currently being intensively investigated.
FUTURE MEDICINAL CHEMISTRY
(2022)
Review
Nutrition & Dietetics
Maria Paz Beyer, Luis A. Videla, Camila Farias, Rodrigo Valenzuela
Summary: This review discusses the therapeutic benefits of docosahexaenoic acid (DHA) and specialized pro-resolving lipid mediators (SPMs) on various diseases. DHA is the precursor of SPMs, which have been considered bioactive compounds for human health. Growing evidence suggests that DHA and SPMs have beneficial effects on the amelioration, regulation, and duration of inflammatory processes through different biological actions.
Review
Biochemistry & Molecular Biology
Cindy Barnig, Gaetan Lutzweiler, Margherita Giannini, Anne Lejay, Anne-Laure Charles, Alain Meyer, Bernard Geny
Summary: This article discusses the inflammatory response and recent discoveries in resolution pathways during skeletal muscle ischemia reperfusion. Lipid mediators play an important role in regulating the inflammatory response, reducing damage caused by ischemia reperfusion, and have potential therapeutic applications.
Review
Biochemistry & Molecular Biology
Ines Ferreira, Filipa Falcato, Narcisa Bandarra, Amelia P. Rauter
Summary: Marine organisms are a valuable source for drug development due to their unique chemical structures. DHA, an omega-3 fatty acid derived from marine sources, has regulatory functions and can be used to synthesize anti-inflammatory SPMs. Further research is needed to explore the potential role of these SPMs in treating COVID-19.
Review
Biochemistry & Molecular Biology
Undurti N. Das
Summary: Sepsis, triggered by microbial infection, injury, or major surgery, involves the activation of the immune system and the release of cytokines. Polyunsaturated fatty acids (PUFAs) and their metabolites have a negative regulatory effect on the inflammatory process, while corticosteroids inhibit the release of PUFAs. Imbalance in PUFAs and failure to suppress the cGAS-STING system at the right time can lead to the onset of sepsis.
Review
Biochemistry & Molecular Biology
Simon C. Dyall, Laurence Balas, Nicolas G. Bazan, J. Thomas Brenna, Nan Chiang, Felipe da Costa Souza, Jesmond Dalli, Thierry Durand, Jean-Marie Galano, Pamela J. Lein, Charles N. Serhan, Ameer Y. Taha
Summary: Polyunsaturated fatty acids are important components of cell membranes and play a role in cellular function. They can also serve as precursors for lipid mediators called oxylipins. Oxylipins are formed through enzymatic or non-enzymatic pathways and include eicosanoids and other lipid mediators. This review summarizes current knowledge about the structure and functions of nonclassical oxylipins.
PROGRESS IN LIPID RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Vaibhav Sahni, Thomas E. Van Dyke
Summary: Inflammation is a crucial part of many disease processes, and most treatments aim to inhibit inflammation for therapeutic outcomes. The resolution of inflammation involves reversing the inflammatory process to a state of homeostasis instead of selectively inhibiting specific components of the inflammatory cascade. The discovery of specialized pro-resolving mediators (SPMs) has revolutionized our understanding of the pathophysiology of diseases. Periodontal disease, previously thought to be caused by microbes, is now recognized as an inflammation-driven process associated with dysbiosis of the oral microbiome, which can be modulated with SPMs for therapeutic benefits.
FRONTIERS IN ORAL HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Undurti N. Das
Summary: Syntaxin regulates pancreatic beta cell mass and participates in insulin secretion. Arachidonic acid (AA) enhances cell membrane fluidity, increases GLUT expression and has anti-inflammatory effects, while prostaglandin E2 (PGE2) activates hypothalamic inflammation and inhibits insulin secretion. Administration of AA and DHA may prevent diabetes.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Medicine, General & Internal
Undurti N. Das
Summary: COVID-19 is caused by SARS-CoV-2 infection. Bioactive lipids, particularly arachidonic acid (AA), play a critical role in inactivating viruses, enhancing immune response, and promoting wound healing and restoration of homeostasis. These lipids also modulate the activity of immune cells and stem cells.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Justyna Kikut, Malgorzata Mokrzycka, Arleta Drozd, Urszula Grzybowska-Chlebowczyk, Maciej Zietek, Malgorzata Szczuko
Summary: The study compared the concentrations of proinflammatory mediators of arachidonic acid (ARA) and linoleic acid (LA) in patients with CD and UC, and identified differences in inflammation levels between the two diseases. Active CD patients had higher concentrations of 15S-HETE than active UC patients, and levels of TXB2, LTB4, and 9S-HODE were higher in active CD compared to inactive CD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Makoto Kurano, Yuko Saito, Baasanjav Uranbileg, Daisuke Saigusa, Kuniyuki Kano, Junken Aoki, Yutaka Yatomi
Summary: This study reveals the association between bioactive lipids and Alzheimer's disease (AD) through analysis of brain samples from AD patients. Specific lipid molecules and metabolites are found to be abnormal in the brains of AD patients, providing new insights into the pathogenesis and pathology of AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.