Possibility of averting cytokine storm in SARS-COV 2 patients using specialized pro-resolving lipid mediators

A New Approach to the Management of COVID-19. Antagonists of IL-6: Siltuximab

(2022) Lucinda Villaescusa et al.   ADVANCES IN THERAPY

COVID-19 and cancer: start the resolution!

(2022) Chantal Barksdale et al.   CANCER AND METASTASIS REVIEWS

Lipoxins modulate neutrophil oxidative burst, integrin expression and lymphatic transmigration differentially in human health and atherosclerosis

(2022) Jamie D. Kraft et al.   FASEB JOURNAL

Lipid mediator n‐3 docosapentaenoic acid‐derived protectin D1 enhances synaptic inhibition of hippocampal principal neurons by interaction with a G‐protein‐coupled receptor

(2022) Apostolos Mikroulis et al.   FASEB JOURNAL

Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201

(2022) Christian Kretzer et al.   Journal of Inflammation Research

Resolvins, Protectins, and Maresins: DHA-Derived Specialized Pro-Resolving Mediators, Biosynthetic Pathways, Synthetic Approaches, and Their Role in Inflammation

(2022) Inês Ferreira et al.   MOLECULES

Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

(2022) Simon C. Dyall et al.   PROGRESS IN LIPID RESEARCH

A newly synthesized 17-epi-NeuroProtectin D1/17-epi-Protectin D1: Authentication and functional regulation of Inflammation-Resolution

(2022) Kajal Hamidzadeh et al.   BIOCHEMICAL PHARMACOLOGY

Macrophages undergo a behavioural switch during wound healing in zebrafish

(2022) Tamara Sipka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of Inflammation and Its Resolution in Disease and Therapeutics

(2022) Sebastián Alfaro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Maresin 2 is an analgesic specialized pro-resolution lipid mediator in mice by inhibiting neutrophil and monocyte recruitment, nociceptor neuron TRPV1 and TRPA1 activation, and CGRP release

(2022) Victor Fattori et al.   NEUROPHARMACOLOGY

Immunomodulation by intravenous omega‐3 fatty acid treatment in older subjects hospitalized for COVID‐19: A single‐blind randomized controlled trial

(2022) Hildur Arnardottir et al.   Clinical and Translational Medicine

Decreased oxidative stress and altered urinary oxylipidome by intravenous omega-3 fatty acid emulsion in a randomized controlled trial of older subjects hospitalized for COVID-19

(2022) Sven-Christian Pawelzik et al.   FREE RADICAL BIOLOGY AND MEDICINE

Coprophagy Prevention Affects the Reproductive Performance in New Zealand White Rabbits Is Mediated through Nox4-ROS-NFκB Pathway

(2022) Zhichao Li et al.   Oxidative Medicine and Cellular Longevity

Role of specialized pro-resolving lipid mediators and their receptors in virus infection: a promising therapeutic strategy for SARS-CoV-2 cytokine storm

(2021) Chang Hoon Lee   ARCHIVES OF PHARMACAL RESEARCH

Immune system response during viral Infections: Immunomodulators, cytokine storm (CS) and Immunotherapeutics in COVID-19

(2021) Faheem Hyder Pottoo et al.   SAUDI PHARMACEUTICAL JOURNAL

Stereoselective Synthesis and Structural Confirmation of the Specialized Pro-Resolving Mediator Resolvin E4

(2021) Amalie Føreid Reinertsen et al.   JOURNAL OF ORGANIC CHEMISTRY

Cysteinyl-specialized proresolving mediators link resolution of infectious inflammation and tissue regeneration via TRAF3 activation

(2021) Nan Chiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of human immune cell subtypes most responsive to IL-1β–induced inflammatory signaling using mass cytometry

(2021) Hema Kothari et al.   Science Signaling

A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution

(2021) Stephania Libreros et al.   Frontiers in Immunology

Resolvin D1 and D2 reduce SARS‐CoV‐2‐induced inflammatory responses in cystic fibrosis macrophages

(2021) Antonio Recchiuti et al.   FASEB JOURNAL

Bioactive Lipid Mediators in the Initiation and Resolution of Inflammation after Spinal Cord Injury

(2021) Samuel David et al.   NEUROSCIENCE

Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders

(2021) Yong-Hyun Han et al.   Biomolecules & Therapeutics

Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19

(2021) Duco Steven Koenis et al.   CIRCULATION RESEARCH

Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome—with a preliminary reference to SARS-CoV-2 pneumonia

(2021) Walter Gottlieb Land   GENES AND IMMUNITY

Effect of Canakinumab vs Placebo on Survival Without Invasive Mechanical Ventilation in Patients Hospitalized With Severe COVID-19

(2021) Roberto Caricchio et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology

(2021) Kinga Tylek et al.   Pharmacological Reports

Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis

(2021) Ana Karla G. Melo et al.   PLoS One

The ‘cytokine storm’: molecular mechanisms and therapeutic prospects

(2021) Rajendra Karki et al.   TRENDS IN IMMUNOLOGY

Effect of resolvin D5 on T cell differentiation and osteoclastogenesis analyzed by lipid mediator profiling in the experimental arthritis

(2021) Hirotaka Yamada et al.   Scientific Reports

Interleukin-6 Perpetrator of the COVID-19 Cytokine Storm

(2021) Jyoti Shekhawat et al.   Indian Journal of Clinical Biochemistry

Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages

(2021) Christian Kretzer et al.   BIOCHEMICAL PHARMACOLOGY

The impact of DAMP-mediated inflammation in severe COVID-19 and related disorders

(2021) Upasana Parthasarathy et al.   BIOCHEMICAL PHARMACOLOGY

Resolvin T-series Reduce Neutrophil Extracellular Traps

(2021) Nan Chiang et al.   BLOOD

Stereoselective Synthesis, Configurational Assignment and Biological Evaluations of the Lipid Mediator RvD2 n‐3 DPA

(2021) Amalie F. Reinertsen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections

(2021) Paul M. Jordan et al.   FEBS Journal

Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19

(2021) Moumita Manik et al.   JOURNAL OF MEDICAL VIROLOGY

Activation of GPR18 by Resolvin D2 Relieves Pain and Improves Bladder Function in Cyclophosphamide-Induced Cystitis Through Inhibiting TRPV1

(2021) Qudong Lu et al.   Drug Design Development and Therapy

Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial

(2021) Jozefien Declercq et al.   Lancet Respiratory Medicine

Dynamic Role of Phospholipases A2 in Health and Diseases in the Central Nervous System

(2021) Grace Y. Sun et al.   Cells

RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome

(2020) Eric D. Hamlett et al.   GLIA

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Resolvin D5, a Lipid Mediator, Inhibits Production of Interleukin-6 and CCL5 Via the ERK-NF- ¥ éSignaling Pathway in Lipopolysaccharide-Stimulated THP-1 Cells

(2020) Hyun-Woo Chun et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Neutrophil chemoattractant receptors in health and disease: double-edged swords

(2020) Mieke Metzemaekers et al.   Cellular & Molecular Immunology

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

(2020) Francesca Coperchini et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Parenteral Fish‐Oil Emulsions in Critically Ill COVID‐19 Emulsions

(2020) Bruce R. Bistrian   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

First total synthesis of the pro-resolving lipid mediator 7(S),12(R),13(S)-Resolvin T2 and its 13(R)-epimer

(2020) Ana R. Rodriguez et al.   TETRAHEDRON LETTERS

Harnessing inflammation resolving‐based therapeutic agents to treat pulmonary viral infections: What can the future offer to COVID‐19?

(2020) Lirlândia P. Sousa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Specialized Pro-Resolving Lipid Mediators: Emerging Therapeutic Candidates for Multiple Sclerosis

(2020) Insha Zahoor et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

(2020) Víctor J. Costela-Ruiz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

(2020) Bingwen Liu et al.   JOURNAL OF AUTOIMMUNITY

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

The COVID-19 Cytokine Storm; What We Know So Far

(2020) Dina Ragab et al.   Frontiers in Immunology

Bioactive Lipids in COVID-19-Further Evidence

(2020) Undurti N. Das   ARCHIVES OF MEDICAL RESEARCH

Specialized pro-resolving mediator network: an update on production and actions

(2020) Nan Chiang et al.   Essays in Biochemistry

Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications

(2020) Masae Iwasaki et al.   INFLAMMATION

Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19

(2020) Xiuhong Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

(2020) Ana Copaescu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A

(2019) Andreas Körner et al.   Nature Communications

Mediators of the Resolution of the Inflammatory Response

(2019) Michelle A. Sugimoto et al.   TRENDS IN IMMUNOLOGY

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

(2019) Yong-Hyun Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid mediators in immune regulation and resolution

(2019) Derek W. Gilroy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration

(2019) Nikolas Giannakis et al.   NATURE IMMUNOLOGY

Resolvin D4 attenuates the severity of pathological thrombosis in mice

(2019) Deya Cherpokova et al.   BLOOD

Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy

(2019) Xin Luo et al.   Frontiers in Pharmacology

Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease

(2019) Cindy Barnig et al.   Frontiers in Immunology

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

(2019) Nan Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolution metabolomes activated by hypoxic environment

(2019) Paul C. Norris et al.   Science Advances

First total syntheses of the pro-resolving lipid mediators 7(S),13(R),20(S)-Resolvin T1 and 7(S),13(R)-Resolvin T4

(2019) Ana R. Rodriguez et al.   TETRAHEDRON LETTERS

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology

(2018) Jesmond Dalli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neutrophils: multitasking first responders of immunity and tissue homeostasis

(2018) Craig N. Jenne et al.   CELL AND TISSUE RESEARCH

Specialized Pro-resolving Mediators Regulate Alveolar Fluid Clearance during Acute Respiratory Distress Syndrome

(2018) Sheng-Wei Jin et al.   CHINESE MEDICAL JOURNAL

Role of Human Macrophage Polarization in Inflammation during Infectious Diseases

(2018) Chiraz Atri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

(2018) Sangsu Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipoxin A4 inhibits UV radiation-induced skin inflammation and oxidative stress in mice

(2018) R.M. Martinez et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair

(2018) Jason Hellmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Frontline Science: Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation

(2018) Jeremy W. Winkler et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases

(2018) Shi Tang et al.   MEDIATORS OF INFLAMMATION

Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke

(2018) Ludmila Belayev et al.   MOLECULAR NEUROBIOLOGY

Anti-cancer and analgesic effects of resolvin D2 in oral squamous cell carcinoma

(2018) Yi Ye et al.   NEUROPHARMACOLOGY

Specialized Proresolving Mediators in Innate and Adaptive Immune Responses in Airway Diseases

(2018) Nandini Krishnamoorthy et al.   PHYSIOLOGICAL REVIEWS

Phospholipase A2 catalysis and lipid mediator lipidomics

(2018) Varnavas D. Mouchlis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis

(2018) E. P. Brennan et al.   DIABETES

5S,15S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1

(2018) Abigail R. Green et al.   BIOCHEMISTRY

Novel mediators and mechanisms in the resolution of infectious inflammation: evidence for vagus regulation

(2018) C. N. Serhan et al.   JOURNAL OF INTERNAL MEDICINE

Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation

(2018) Paul C. Norris et al.   Scientific Reports

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

(2017) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Prolonged immune alteration following resolution of acute inflammation in humans

(2017) Madhur P. Motwani et al.   PLoS One

The novel lipid mediator PD1 n-3 DPA : An overview of the structural elucidation, synthesis, biosynthesis and bioactions

(2017) Trond Vidar Hansen et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E 2

(2017) Justine Newson et al.   Cell Reports

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia

(2016) Jennifer K. Colby et al.   AMERICAN JOURNAL OF PATHOLOGY

The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation

(2016) Sesquile Ramon et al.   AMERICAN JOURNAL OF PATHOLOGY

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

(2016) Ulrike Garscha et al.   BIOCHEMICAL PHARMACOLOGY

Resolution of Acute Inflammation and the Role of Resolvins in Immunity, Thrombosis, and Vascular Biology

(2016) Brian E. Sansbury et al.   CIRCULATION RESEARCH

n-3 Fatty acid supplementation and proresolving mediators of inflammation

(2016) Anne E. Barden et al.   CURRENT OPINION IN LIPIDOLOGY

Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins

(2016) Karoline G. Primdahl et al.   JOURNAL OF NATURAL PRODUCTS

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

(2016) Jesmond Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D3 multi-level proresolving actions are host protective during infection

(2016) Paul C. Norris et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Bioanalytical chemistry of cytokines – A review

(2015) Julie A. Stenken et al.   ANALYTICA CHIMICA ACTA

Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection

(2015) Yumiko Imai   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

(2015) Charles N. Serhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Transcellular biosynthesis of eicosanoid lipid mediators

(2015) Valérie Capra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity

(2015) Denise Morais da Fonseca et al.   CELL

Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease

(2015) Emma Börgeson et al.   Cell Metabolism

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein

(2015) Christoph Lehmann et al.   FASEB JOURNAL

Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

(2015) Jesmond Dalli et al.   FASEB JOURNAL

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammation of the Dental Pulp

(2015) Sang Hyuk Park et al.   MEDIATORS OF INFLAMMATION

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Lipoxin A4 attenuates radicular pain possibly by inhibiting spinal ERK, JNK and NF-κB/p65 and cytokine signals, but not p38, in a rat model of non-compressive lumbar disc herniation

(2015) G.-S Miao et al.   NEUROSCIENCE

The resolution of inflammation: Principles and challenges

(2015) Sarah E. Headland et al.   SEMINARS IN IMMUNOLOGY

First total synthesis of pro-resolving and tissue-regenerative Maresin sulfido-conjugates

(2015) Ana R. Rodriguez et al.   TETRAHEDRON LETTERS

Resolution of acute inflammation bridges the gap between innate and adaptive immunity

(2014) J. Newson et al.   BLOOD

The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesisin vitroandin vivoby targeting 5-lipoxygenase-activating protein (FLAP)

(2014) C Pergola et al.   BRITISH JOURNAL OF PHARMACOLOGY

Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies

(2014) Marion Leick et al.   CELL AND TISSUE RESEARCH

Roles of resolvins in the resolution of acute inflammation

(2014) Qing Qu et al.   CELL BIOLOGY INTERNATIONAL

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

Cutting Edge: Maresin-1 Engages Regulatory T Cells To Limit Type 2 Innate Lymphoid Cell Activation and Promote Resolution of Lung Inflammation

(2014) Nandini Krishnamoorthy et al.   JOURNAL OF IMMUNOLOGY

Total Synthesis of the Lipid Mediator PD1n-3 DPA: Configurational Assignments and Anti-inflammatory and Pro-resolving Actions

(2014) Marius Aursnes et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis and Anti-inflammatory and Pro-resolving Activities of 22-OH-PD1, a Monohydroxylated Metabolite of Protectin D1

(2014) Jørn E. Tungen et al.   JOURNAL OF NATURAL PRODUCTS

Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation

(2014) Denise Alves Perez et al.   MEDIATORS OF INFLAMMATION

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages

(2014) Bin Deng et al.   PLoS One

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation

(2014) P. C. Norris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

(2014) J. Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling

(2014) Karen Wagner et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis

(2013) Ha-Na Lee et al.   BIOCHEMICAL PHARMACOLOGY

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation

(2013) V. Brancaleone et al.   BLOOD

The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

(2013) Masayuki Morita et al.   CELL

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

(2013) Jesmond Dalli et al.   CHEMISTRY & BIOLOGY

Resolution phase lipid mediators of inflammation: agonists of resolution

(2013) Charles N. Serhan et al.   CURRENT OPINION IN PHARMACOLOGY

15-Epi-lipoxin A4 inhibits human neutrophil superoxide anion generation by regulating polyisoprenyl diphosphate phosphatase 1

(2013) Troy Carlo et al.   FASEB JOURNAL

Neutrophil Transmigration: Emergence of an Adhesive Cascade within Venular Walls

(2013) Mathieu-Benoit Voisin et al.   Journal of Innate Immunity

Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology

(2013) K A Shirey et al.   Mucosal Immunology

Stereocontrolled Total Synthesis of the Potent Anti-inflammatory and Pro-resolving Lipid Mediator Resolvin D3 and Its Aspirin-Triggered 17R-Epimer

(2013) Jeremy W. Winkler et al.   ORGANIC LETTERS

Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease

(2013) Matthew Spite   PROCEEDINGS OF THE NUTRITION SOCIETY

Novel n-3 Immunoresolvents: Structures and Actions

(2013) Jesmond Dalli et al.   Scientific Reports

Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins

(2013) Driss El Kebir et al.   Frontiers in Immunology

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

(2012) Sriram Krishnamoorthy et al.   AMERICAN JOURNAL OF PATHOLOGY

Efficacy and safety of 15(R/S)-methyl-lipoxin A4in topical treatment of infantile eczema

(2012) S.-H. Wu et al.   BRITISH JOURNAL OF DERMATOLOGY

Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke

(2012) Nicolas G. Bazan et al.   EXPERIMENTAL NEUROLOGY

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid

(2012) Yosuke Isobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resolvin E2 Formation and Impact in Inflammation Resolution

(2012) S. F. Oh et al.   JOURNAL OF IMMUNOLOGY

Innate Immune Cells in Liver Inflammation

(2012) Evaggelia Liaskou et al.   MEDIATORS OF INFLAMMATION

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor

(2012) F. A. Pamplona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress

(2012) Rina Takamiya et al.   FEBS Open Bio

Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution

(2011) Gabrielle Fredman et al.   BIOCHEMICAL JOURNAL

Esterified eicosanoids: Generation, characterization and function

(2011) Victoria J. Hammond et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Resolvins and Protectins in Inflammation Resolution

(2011) Charles N. Serhan et al.   CHEMICAL REVIEWS

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Novel Proresolving Aspirin-Triggered DHA Pathway

(2011) Charles N. Serhan et al.   CHEMISTRY & BIOLOGY

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice

(2011) Jason Hellmann et al.   FASEB JOURNAL

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Hemophagocytosis causes a consumptive anemia of inflammation

(2011) Erin E. Zoller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing

(2011) L. V. Norling et al.   JOURNAL OF IMMUNOLOGY

Resolving TRPV1- and TNF- -Mediated Spinal Cord Synaptic Plasticity and Inflammatory Pain with Neuroprotectin D1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

Lipoxin A4 Increases Survival by Decreasing Systemic Inflammation and Bacterial Load in Sepsis

(2011) Jean Walker et al.   SHOCK

Lipoxin and Aspirin-Triggered Lipoxins

(2011) Mario Romano   TheScientificWorldJOURNAL

Aspirin-Triggered Lipoxin and Resolvin E1 Modulate Vascular Smooth Muscle Phenotype and Correlate with Peripheral Atherosclerosis

(2010) Karen J. Ho et al.   AMERICAN JOURNAL OF PATHOLOGY

Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception

(2010) S Bang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The complement system

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Novel Lipid Mediators Promote Resolution of Acute Inflammation

(2010) Matthew Spite et al.   CIRCULATION RESEARCH

Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids

(2010) Sagie Schif-Zuck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Controlling Herpes Simplex Virus-Induced Ocular Inflammatory Lesions with the Lipid-Derived Mediator Resolvin E1

(2010) N. K. Rajasagi et al.   JOURNAL OF IMMUNOLOGY

Resolvins and protectins: mediating solutions to inflammation

(2009) Payal Kohli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium–induced colitis

(2009) Tsukasa Ishida et al.   INFLAMMATORY BOWEL DISEASES

Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis

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Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

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Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection

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Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils

(2009) Victor L. Marcheselli et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

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