Therapeutic target database update 2014: a resource for targeted therapeutics

International classification of diseases, 10th edition, clinical modification and procedure coding system: descriptive overview of the next generation HIPAA code sets

(2014) Steven J Steindel   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Personalized cardiovascular medicine: concepts and methodological considerations

(2013) Henry Völzke et al.   Nature Reviews Cardiology

Pharmacogenetics in the evaluation of new drugs: a multiregional regulatory perspective

(2013) Marc Maliepaard et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanistic biomarkers for clinical decision making in rheumatic diseases

(2013) William H. Robinson et al.   Nature Reviews Rheumatology

Biomarkers in Amyloid-β Immunotherapy Trials in Alzheimer’s Disease

(2013) Kaj Blennow et al.   NEUROPSYCHOPHARMACOLOGY

The Early Detection Research Network: 10-Year Outlook

(2012) S. Srivastava   CLINICAL CHEMISTRY

Management of Small Cell Lung Cancer

(2012) Raffaele Califano et al.   DRUGS

Macrocycles in new drug discovery

(2012) Jamie Mallinson et al.   Future Medicinal Chemistry

Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

(2012) Axel Hauschild et al.   LANCET

Analysis of bypass signaling in EGFR pathway and profiling of bypass genes for predicting response to anticancer EGFR tyrosine kinase inhibitors

(2012) Jingxian Zhang et al.   Molecular BioSystems

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

(2012) Zhao Chen et al.   NATURE

Novel biomarkers in chronic heart failure

(2012) Tariq Ahmad et al.   Nature Reviews Cardiology

Public–private collaborations and partnerships in stratified medicine: making sense of new interactions

(2012) Joanna Chataway et al.   New Biotechnology

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

Database resources of the National Center for Biotechnology Information

(2012)   NUCLEIC ACIDS RESEARCH

Activation of PI3K/AKT and MAPK Pathway through a PDGFRβ-Dependent Feedback Loop Is Involved in Rapamycin Resistance in Hepatocellular Carcinoma

(2012) Quan-Lin Li et al.   PLoS One

Stratified Medicine and Reimbursement Issues

(2012) Hans-Joerg Fugel et al.   Frontiers in Pharmacology

Molecular Characteristics Predict Clinical Outcomes: Prospective Trial Correlating Response to the EGFR Tyrosine Kinase Inhibitor Gefitinib with the Presence of Sensitizing Mutations in the Tyrosine Binding Domain of the EGFR Gene

(2011) N. A. Rizvi et al.   CLINICAL CANCER RESEARCH

Increased Detection Sensitivity for KRAS Mutations Enhances the Prediction of Anti-EGFR Monoclonal Antibody Resistance in Metastatic Colorectal Cancer

(2011) F. Molinari et al.   CLINICAL CANCER RESEARCH

Use of ATC to describe duplicate medications in primary care prescriptions

(2011) Chiao Mei Lim et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Getting pharmaceutical R&D back on target

(2011) Mark E Bunnage   Nature Chemical Biology

Predictive biomarkers: a paradigm shift towards personalized cancer medicine

(2011) Nicholas B. La Thangue et al.   Nature Reviews Clinical Oncology

Quantifying factors for the success of stratified medicine

(2011) Mark R. Trusheim et al.   NATURE REVIEWS DRUG DISCOVERY

Trends in the exploitation of novel drug targets

(2011) Mathias Rask-Andersen et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical usefulness of novel prognostic biomarkers in patients on hemodialysis

(2011) Alberto Ortiz et al.   Nature Reviews Nephrology

In search of biomarkers for autism: scientific, social and ethical challenges

(2011) Pat Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery

(2011) F. Zhu et al.   NUCLEIC ACIDS RESEARCH

Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting

(2011) F. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERBB2 and TOP2A in Breast Cancer: A Comprehensive Analysis of Gene Amplification, RNA Levels, and Protein Expression and Their Influence on Prognosis and Prediction

(2010) J. C. Brase et al.   CLINICAL CANCER RESEARCH

Marine natural products as sources of novel scaffolds: achievement and concern

(2010) De-Xin Kong et al.   DRUG DISCOVERY TODAY

Drug discovery: Inhibitors that activate

(2010) Karen Cichowski et al.   NATURE

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

The importance of new companies for drug discovery: origins of a decade of new drugs

(2010) Robert Kneller   NATURE REVIEWS DRUG DISCOVERY

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

EGFR-directed therapies to treat non-small-cell lung cancer

(2009) Cheryl Ho et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Drug and Drug Candidate Building Block Analysis

(2009) Junmei Wang et al.   Journal of Chemical Information and Modeling

Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC

(2009) Helena Linardou et al.   Nature Reviews Clinical Oncology

Natural products to drugs: natural product-derived compounds in clinical trials

(2008) Mark S. Butler   NATURAL PRODUCT REPORTS