HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

(2012) Frauke Christ et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

(2012) Manuel Tsiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

(2012) Jacques J. Kessl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlation of Recombinant Integrase Activity and Functional Preintegration Complex Formation during Acute Infection by Replication-Defective Integrase Mutant Human Immunodeficiency Virus

(2012) X. Li et al.   JOURNAL OF VIROLOGY

LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

(2012) Rik Schrijvers et al.   PLoS Pathogens

The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones

(2011) N. A. Gillet et al.   BLOOD

Design, Synthesis, and Evaluation of Novel 3,6-Diaryl-4-aminoalkoxyquinolines as Selective Agonists of Somatostatin Receptor Subtype 2

(2011) Scott E. Wolkenberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral Capsid

(2011) K. A. Matreyek et al.   JOURNAL OF VIROLOGY

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75

(2011) Jacques J. Kessl et al.   NUCLEIC ACIDS RESEARCH

HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2

(2011) Karen E. Ocwieja et al.   PLoS Pathogens

Identification and Characterization of Persistent Intracellular Human Immunodeficiency Virus Type 1 Integrase Strand Transfer Inhibitor Activity

(2010) Yasuhiro Koh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

(2010) Frauke Christ et al.   Nature Chemical Biology

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

(2010) A. L. Ferris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in the accessibility of the HIV-1 Integrase C-terminus in the presence of cellular proteins

(2010) Sofia Benkhelifa-Ziyyat et al.   Retrovirology

Quantitative analysis of HIV-1 preintegration complexes

(2009) Alan Engelman et al.   METHODS

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

(2009) Stephen Hare et al.   PLoS Pathogens

Structural Basis for Functional Tetramerization of Lentiviral Integrase

(2009) Stephen Hare et al.   PLoS Pathogens

Integrase, LEDGF/p75 and HIV replication

(2008) E. M. Poeschla   CELLULAR AND MOLECULAR LIFE SCIENCES

Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein

(2008) Christopher J. McKee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The LEM Domain Proteins Emerin and LAP2  Are Dispensable for Human Immunodeficiency Virus Type 1 and Murine Leukemia Virus Infections

(2008) A. Mulky et al.   JOURNAL OF VIROLOGY

Identification and Characterization of PWWP Domain Residues Critical for LEDGF/p75 Chromatin Binding and Human Immunodeficiency Virus Type 1 Infectivity

(2008) M.-C. Shun et al.   JOURNAL OF VIROLOGY

The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication

(2008) Alan Engelman et al.   PLoS Pathogens