Article
Neurosciences
Riku Kawanabe, Kohei Yoshihara, Izuho Hatada, Makoto Tsuda
Summary: Astrocytes in the spinal dorsal horn have increased Ca2+ levels following intraplantar injection of formalin, with mechanisms regulated by descending noradrenergic signals. The Ca2+ response can be suppressed by ablating locus coeruleus-NAergic neurons projecting to the SDH or by losing alpha(1A)-adrenaline receptors in astrocytes.
Article
Neurosciences
Chaofan Wan, Yunlong Xu, Baoyan Cen, Yucen Xia, Lin Yao, Yuanjia Zheng, Jiaying Zhao, Su He, Yongjun Chen
Summary: Electroacupuncture (EA) treatment can alleviate chronic inflammatory pain, with the involvement of NRG1-ErbB4 signaling pathway.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Shingo Nakamura, Takahiro Nonaka, Shuji Komatsu, Toshihiko Yamada, Tatsuo Yamamoto
Summary: The mechanism by which acetaminophen produces its analgesic effects involves the activation of the spinal 5-hydroxytryptamine (5-HT) receptor, possibly through the metabolite N-arachidonoylphenolamine (AM404). Both oral acetaminophen and intracerebroventricular AM404 induce spinal 5-HT release and analgesic effects in rat formalin tests, but with differing interactions with 5-HT receptor antagonists.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Guadalupe Martinez-Lorenzana, Lourdes Palma-Tirado, Carmen Cifuentes-Diaz, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: Oxytocin and its receptor play a role in analgesia at the spinal dorsal horn, possibly through a presynaptic mechanism or mediated by GABA interneurons. Additionally, the expression of oxytocin receptor in glial tissue at the spinal dorsal horn requires further investigation in nociception assays.
Article
Anesthesiology
Marcel Simis, Kevin Pacheco-Barrios, Elif Uygur-Kucukseymen, Luis Castelo-Branco, Linamara R. Battistella, Felipe Fregni
Summary: The study found that 74% of SCI patients reported SCI-related pain. Results showed that lower alpha and beta frequencies were associated with pain presence and higher pain levels, patients with pain had decreased peak alpha-theta frequency, more relative theta power was related to low CPM efficiency, and higher relative theta power was associated with lower CPM efficiency. These findings suggest potential EEG-based biomarkers and interventions for pain management in post-SCI population.
Article
Anesthesiology
Shiyun Jin, Resat Cinar, Xudong Hu, Yuhong Lin, Guoxiang Luo, David M. Lovinger, Ye Zhang, Li Zhang
Summary: The study reveals that ALDH2 in spinal astrocytes plays a crucial role in mediating ethanol metabolism and ethanol-induced analgesic effects by promoting GABA synthesis and transmission in the spinal cord.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Review
Neurosciences
Lonne Heijmans, Martijn R. Mons, Elbert A. Joosten
Summary: This systematic review explores the involvement of the serotonergic system in modulating pain signaling, with a focus on both healthy adult rodents and those with chronic neuropathic pain. It highlights the role of specific serotonin receptors in inhibiting or facilitating pain modulation, and suggests that targeting these receptors could lead to improved pharmacological or neuromodulatory treatments for neuropathic pain. Additionally, the study identifies the descending serotonergic system as a key target for mechanism-based pain relief, particularly in the context of spinal cord stimulation.
Article
Engineering, Biomedical
Evgenii Kim, Jeungeun Kum, Hyungmin Kim
Summary: Compared to current non-invasive methods, focused ultrasound provides better spatial resolution and penetration depth. This study investigates the application of trans-spinal focused ultrasound (tsFUS) on a mouse model to modulate the descending pathways in a non-invasive manner. The results show the ability of tsFUS to modulate motor signals and manage tremors safely, providing a foundation for the trans-spinal application of focused ultrasound to motor-related disorders.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2022)
Review
Health Care Sciences & Services
Giusy Guzzi, Attilio Della Torre, Domenico La Torre, Giorgio Volpentesta, Carmelino Angelo Stroscio, Angelo Lavano, Federico Longhini
Summary: Chronic low-back pain is a common disease with negative impacts on patients' quality of life and healthcare costs. When conventional treatments fail, patients may consider Spinal Cord Stimulation (SCS), which can effectively reduce symptoms in well-selected patients for up to eight years.
Article
Biology
Alexandra Tinnermann, Christian Sprenger, Christian Buechel
Summary: This study investigated the effects of the opioid remifentanil on healthy male participants using combined corticospinal functional MRI. The results showed that opioids altered activity in regions involved in pain processing and pain modulation and coupling strength could differentiate between opioid analgesia and unspecific reductions in pain.
Article
Multidisciplinary Sciences
Peyman Sahbaie, Karen-Amanda Irvine, Xiao-You Shi, J. David Clark
Summary: Studies have shown that DNIC is reduced after TBI, and sensitivity to α2 adrenoceptor agonists is decreased. However, enhancing serotonergic signaling can effectively restore DNIC after TBI, suggesting it as a potential treatment strategy for post-TBI pain.
SCIENTIFIC REPORTS
(2022)
Review
Anesthesiology
Harsha Shanthanna, Sam Eldabe, David Anthony Provenzano, Yaping Chang, Daniel Adams, Imad Kashir, Akash Goel, Chenchen Tian, Rachel J. Couban, Tal Levit, Jonathan M. Hagedorn, Samer Narouze
Summary: This study reviews the evidence on patient selection and the role of trials in spinal cord stimulation (SCS) therapy. It finds that due to the lack of a consistent approach, trials are important in excluding patients who do not benefit from or cannot tolerate the therapy.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Clinical Neurology
Eileen Nguyen, Kelly M. Smith, Nathan Cramer, Ruby A. Holland, Isabel H. Bleimeister, Krystal Flores-Felix, Hanna Silberberg, Asaf Keller, Claire E. Le Pichon, Sarah E. Ross
Summary: By using molecular, tracing, and behavioural approaches, Nguyen et al. discovered that neurons containing the kappa-opioid receptor in the rostral ventromedial medulla can robustly modulate itch and pain behaviours bidirectionally, shedding light on a distinct population of neurons that inhibit itch and nociception.
Article
Clinical Neurology
Si-Yi Mo, Yang Xue, Yuan Li, Yao-Jun Zhang, Xiao-Xiang Xu, Kai-Yuan Fu, Barry J. Sessle, Qiu-Fei Xie, Ye Cao
Summary: This study investigated the involvement of the serotonin pathway from the rostral ventromedial medulla (RVM) to the spinal trigeminal nucleus (Sp5) in primary myofascial orofacial hyperalgesia after occlusal alteration. Upregulation of the 5-HT3B receptor subtype in the Sp5 was found in rats with delayed removal of occlusal interference (REOI) and rats with persistent occlusal interference (PEOI). The concentration of 5-HT in Sp5 increased significantly only in REOI rats. Pharmacological antagonism or manipulation of the RVM 5-HT neurons reversed the hyperalgesia in REOI rats but only transiently reversed the hyperalgesia in PEOI rats.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Clinical Neurology
Guiomar Niso, Marleen C. Tjepkema-Cloostermans, Mathieu W. P. M. Lenders, Cecile C. de Vos
Summary: This explorative study assessed the influence of attention on somatosensory evoked brain responses under conventional tonic SCS and burst SCS. Results indicated that burst SCS may reduce cortical attention to somatosensory stimuli to a larger extent than conventional SCS, which helps understand why burst SCS is more effective for certain chronic pain patients.
FRONTIERS IN NEUROLOGY
(2021)
Letter
Neurosciences
Miguel Condes-Lara, Hector Zayas-Gonzalez, Alfredo Manzano-Garcia, Estefania Cordova-Quiroz, Juan Granados-Mortera, Marco Garcia-Cuevas, Julio Morales-Gomez, Abimael Gonzalez-Hernandez
CNS NEUROSCIENCE & THERAPEUTICS
(2016)
Article
Anesthesiology
A. Manzano-Garcia, A. Gonzalez-Hernandez, I. A. Tello-Garcia, G. Martinez-Lorenzana, M. Condes-Lara
EUROPEAN JOURNAL OF PAIN
(2018)
Article
Anesthesiology
Abimael Gonzalez-Hernandez, Alfredo Manzano-Garcia, Guadalupe Martinez-Lorenzana, Irma A. Tello-Garcia, Martha Carranza, Carlos Aramburo, Miguel Condes-Lara
Article
Neurosciences
Enrique Garcia-Boll, Guadalupe Martinez-Lorenzana, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
Article
Neurosciences
M. Condes-Lara, G. Martinez-Lorenzana, G. Rojas-Piloni, I. A. Tello-Garcia, A. Manzano-Garcia, E. Rubio-Beltran, A. Gonzalez-Hernandez
Article
Neurosciences
Mohammed Gamal-Eltrabily, Cecilia Marquez-Morales, Guadalupe Martinez-Lorenzana, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
NEUROSCIENCE LETTERS
(2018)
Review
Pharmacology & Pharmacy
Raquel Guerrero-Alba, Paulino Barragan-Iglesias, Abimael Gonzalez-Hernandez, Eduardo E. Valdez-Morales, Vinicio Granados-Soto, Miguel Condes-Lara, Martin G. Rodriguez, Bruno A. Marichal-Cancino
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Neurosciences
Javier Bejar-Alonso, Guadalupe Martinez-Lorenzana, Abimael Gonzalez-Hernandez, Ulises Cortes, Miguel Condes-Lara
NEUROSCIENCE LETTERS
(2019)
Article
Anesthesiology
Hector Zayas-Gonzalez, Abimael Gonzalez-Hernandez, Alfredo Manzano-Garcia, Donaciano Hernandez-Rivero, Marco Antonio Garcia-Cuevas, Juan Carlos Granados-Mortera, Liliana Vaca-Aguirre, Sergio Flores-Fierro, Guadalupe Martinez-Lorenzana, Miguel Condes-Lara
EUROPEAN JOURNAL OF PAIN
(2019)
Article
Neurosciences
Abimael Gonzalez-Hernandez, Antonio Espinosa De Los Monteros-Zuniga, Guadalupe Martinez-Lorenzana, Miguel Condes-Lara
EXPERIMENTAL BRAIN RESEARCH
(2019)
Article
Neurosciences
Enrique Garcia-Boll, Guadalupe Martinez-Lorenzana, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
EXPERIMENTAL NEUROLOGY
(2020)
Article
Cell Biology
Irma A. Tello-Garcia, Jesus Perez-Ortega, Guadalupe Martinez-Lorenzana, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Article
Biochemical Research Methods
Guadalupe Martinez-Lorenzana, Mohammed Gamal-Eltrabily, Irma Alejandra Tello-Garcia, Ataulfo Martinez-Torres, Marymar Becerra-Gonzalez, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: The study showcases the application of CLARITY technique in visualizing neuronal connections and innervations in the nervous system in a transparent manner. Results indicate the reliability of CLARITY when combined with other techniques, providing valuable insights into neuroanatomical structures.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Anesthesiology
Ana B. Salinas-Abarca, Francisco G. Vazquez-Cuevas, Adriana Gonzalez-Gallardo, Guadalupe Martinez-Lorenzana, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: Sexual dimorphism plays a significant role in pain processing and response to analgesic drugs. Oxytocin showed a preference for preventing LPS-induced hypersensitivity in male rats compared to females, indicating a potential gender-specific analgesic effect. The results suggest that different strategies may be needed to treat pain in men and women, with oxytocin potentially being more effective for pain with an inflammatory component in men.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Anatomy & Morphology
Rafael Olivares-Moreno, Yunuen Moreno-Lopez, Luis Concha, Guadalupe Martinez-Lorenzana, Miguel Condes-Lara, Matilde Cordero-Erausquin, Gerardo Rojas-Piloni
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)