Review
Endocrinology & Metabolism
Haiyan Zheng, Ji Yeon Lim, Yerin Kim, Sang Taek Jung, Sun Wook Hwang
Summary: Oxytocin and vasopressin, neurohypophyseal hormones, play a central role in regulating bodily homeostasis and are strongly involved in downregulating pain. By modulating nociceptors, the first component of the pain signaling pathway, these peptides contribute to pain attenuation, sparking scientific interest in their physiological processes.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ewa Szczepanska-Sadowska, Agnieszka Wsol, Agnieszka Cudnoch-Jedrzejewska, Tymoteusz Zera
Summary: Oxytocin and vasopressin play important roles in the brain and peripheral organs, and their secretion is influenced by various factors. Inappropriate regulation may contribute to the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Reproductive Biology
Ricardo Mondragon-Ceballos, Genesis Chantal Hernandez-Vazquez, Susana Rojas-Maya, Monica Dafne Garcia-Granados, Jaqueline Lugo-Ferrer, Leonor Estela Hernandez-Lopez
Summary: In stump-tailed macaques, male-female friendships promote higher post-copulatory oxytocin concentrations and better physiological conditions for males. As closeness between males and females increases, sperm concentration, immotile and motile sperm decrease gradually.
Review
Endocrinology & Metabolism
Ato O. Aikins, Dianna H. Nguyen, Obed Paundralingga, George E. Farmer, Caroline Gusson Shimoura, Courtney Brock, J. Thomas Cunningham
Summary: AVP and OXY are released by magnocellular neurosecretory cells projecting to the posterior pituitary. While traditionally not believed to contribute to basal cardiovascular function, recent studies suggest potential re-evaluation as evidence indicates their role in cardiovascular pathophysiology.
Article
Neurosciences
Jack H. Taylor, Noah S. Campbell, Jeanne M. Powell, H. Elliott Albers, Aubrey M. Kelly
Summary: The nonapeptide system plays a crucial role in regulating various social behaviors in different species. This study maps the distribution of oxytocin and vasopressin receptors in the brain of male and female Mongolian gerbils and explores the influence of gonadal sex on these receptors. The findings provide a foundation for future research on manipulating the nonapeptide system to study social behavior.
Review
Biochemistry & Molecular Biology
Olga Wronikowska-Denysiuk, Weronika Mrozek, Barbara Budzynska
Summary: Drug abuse is a global problem that has negative consequences on physical, mental, and economic aspects. The oxytocin (OT) and vasopressin (AVP) systems have shown potential as therapeutic targets for drug abuse treatment. Both OT and AVP can reduce drug consumption and ameliorate their rewarding effects. Additionally, these neuropeptides are involved in social and reward behaviors. Therefore, understanding the relationship between OT and AVP and the behavioral effects of drugs of abuse may contribute to more successful drug development.
Article
Biology
Hiroki Tanaka, Kuniyuki Nishina, Qiulu Shou, Hidehiko Takahashi, Masamichi Sakagami, Tetsuya Matsuda, Miho Inoue-Murayama, Haruto Takagishi
Summary: This study shows the association between genetic mutations in three genes associated with human sociality and individuals' aversion to inequity. The participants took part in five economic game experiments and their behavioral responses were used to calculate the level of disadvantageous inequity aversion and advantageous inequity aversion. The study found that there was an association between the AVPR1A gene mutation and advantageous inequity aversion, suggesting the important role of AVPR1A in aversion when individuals' gain is greater than that of others.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Valeska Cid-Jofre, Macarena Moreno, Miguel Reyes-Parada, Georgina M. Renard
Summary: Oxytocin and vasopressin, originally known for their roles in reproduction and water homeostasis, have emerged as potential therapeutic targets for neuropsychiatric disorders. Novel ligands have been developed due to their chemical-physical characteristics, paving the way for clinical and preclinical trials in the treatment of CNS disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Shuxia Yao, Keith Maurice Kendrick
Summary: Intranasal administration of oxytocin and vasopressin has been widely used to modulate social cognition, but their effects are not consistent. The penetration of these neuropeptides into the brain following intranasal administration is debated. Different routes of administration and dose magnitude and frequency can lead to different functional outcomes. Understanding these factors is important for optimizing the desired effects of intranasal treatment.
Article
Behavioral Sciences
A. M. Lotz, R. S. M. Buisman, K. Alyousefi-van Dijk, A. M. Witte, M. J. Bakermans-Kranenburg, M. W. F. T. Verhees
Summary: This study explores the hormonal correlates of paternal sensitivity and finds no significant associations between sensitivity and basal hormone levels or reactivity. However, it reveals an interaction between cortisol and testosterone in their effects on paternal sensitive parenting.
HORMONES AND BEHAVIOR
(2022)
Article
Anatomy & Morphology
Jeanne M. Powell, Kiyoshi Inoue, Kelly J. Wallace, Ashley W. Seifert, Larry J. Young, Aubrey M. Kelly
Summary: The nonapeptide system, through the activation of oxytocin and vasopressin receptors, modulates various social behaviors. This study mapped the distribution and expression of OXTR and AVPR1A receptors in the spiny mouse brain and found differences between males and females in the binding densities and co-expression patterns in brain regions involved in social behavior and reward. These findings provide important insights for studying nonapeptide-mediated behavior in a highly social species.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Neurosciences
Krzysztof M. Wilczynski, Aleksandra Stasik, Lena Cichon, Aleksandra Augusciak-Duma, Malgorzata Janas-Kozik
Summary: Autism spectrum disorders (ASD) are a heterogeneous group of disorders that affect every population. Its pathogenesis involves the interaction of genetic and environmental factors. Social communication deficits are the main symptom of ASD, which lead to difficulties in everyday functioning.
Article
Pharmacology & Pharmacy
Asmaa H. Nasser, Abdallah M. Gendy, Mohammed F. El-Yamany, Dalia M. El-Tanbouly
Summary: This study investigated the mechanism of neuropathic pain alleviation after paclitaxel administration. It was found that trimetazidine (TMZ) promotes the activation of extracellular signal-regulated kinases (ERK1/2) and upregulates neuronal progranulin (PGRN) and Notch1 receptors. This leads to the preservation of myelinated nerve fibers, alleviation of thermal, cold, and mechanical hyperalgesia/allodynia, and an anti-inflammatory effect.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Biology
Rebecca Polk, Marilyn Horta, Tian Lin, Eric Porges, Marite Ojeda, Hans P. Nazarloo, C. Sue Carter, Natalie C. Ebner
Summary: This study investigated the associations between plasma oxytocin and arginine-vasopressin levels and dynamic emotion identification accuracy in older men. The results showed that higher plasma oxytocin levels were associated with lower accuracy, and this relationship was fully mediated by cognition. In contrast, plasma arginine-vasopressin levels did not show any association with dynamic emotion identification accuracy.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Psychiatry
Kaat Alaerts, Sylvie Bernaerts, Nicole Wenderoth
Summary: Neuroimaging clinical trials exploring the effects of intranasal oxytocin administration on the brain revealed that the amygdala plays a crucial role in these effects. This study aimed to investigate how multiple-dose oxytocin treatment affects intrinsic amygdala function in individuals with autism spectrum disorder (ASD). The results showed that oxytocin decreased amygdala activity and modulated cross-frequency interactions, resulting in improved feelings of tension. The findings contribute to a better understanding of the neuromodulatory effects of oxytocin in ASD.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Enrique Garcia-Boll, Guadalupe Martinez-Lorenzana, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
EXPERIMENTAL NEUROLOGY
(2020)
Review
Biochemistry & Molecular Biology
Abimael Gonzalez-Hernandez, Miguel Condes-Lara, Enrique Garcia-Boll, Carlos M. Villalon
Summary: Neuropeptides play an important role in migraine pathophysiology, with molecules such as CGRP, PACAP, OT, and orexins showing potential as novel targets for treatment. However, targeting these neuropeptide systems may lead to both antimigraine effects and potential side effects due to their complex intracellular mechanisms. Pharmacokinetics issues may also limit the use of molecules targeting neuropeptidergic transmission.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Neurosciences
Mohammed Gamal-Eltrabily, Guadalupe Martinez-Lorenzana, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: Nociception modulation involves multiple cortical areas and mechanisms, including both descending modulation at spinal level and cortico-cortical or cortico-subcortical interactions. Understanding the involvement of these areas and the neurotransmitters/neuromodulators studied in each area is crucial for pain modulation.
Article
Biochemical Research Methods
Guadalupe Martinez-Lorenzana, Mohammed Gamal-Eltrabily, Irma Alejandra Tello-Garcia, Ataulfo Martinez-Torres, Marymar Becerra-Gonzalez, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: The study showcases the application of CLARITY technique in visualizing neuronal connections and innervations in the nervous system in a transparent manner. Results indicate the reliability of CLARITY when combined with other techniques, providing valuable insights into neuroanatomical structures.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Biochemistry & Molecular Biology
Antonio Espinosa De los Monteros-Zuniga, Guadalupe Martinez-Lorenzana, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
Summary: Behavioral and electrophysiological data demonstrate that oxytocin inhibits pain transmission at the spinal level by activating OTRs, which can mediate two distinct intracellular pathways - Gq (PLC/NOS/GC/K-ATP(+)) or Gi proteins, leading to differential effects on early and late nociceptive responses.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Abimael Gonzalez-Hernandez, Bruno A. Marichal-Cancino, Carlos M. Villalon
Summary: Monoclonal antibodies act as prophylactic antimigraine agents by targeting CGRP or its receptors, revolutionizing the treatment of this disorder. Despite their long half-lives and hepato-friendly properties, potential cardiovascular side effects and immunogenicity induced by autoantibodies against mAbs present safety concerns for long-term use.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Review
Clinical Neurology
Bruno A. Marichal-Cancino, Abimael Gonzalez-Hernandez, Raquel Guerrero-Alba, Roberto Medina-Santillan, Carlos M. Villalon
Summary: Migraine involves neurovascular, functional, and anatomical alterations, and there is no ideal preventive medication currently. However, some prophylactic medications may help decrease the frequency of migraine days. The mechanisms of action involved in antimigraine prophylaxis remain elusive.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2021)
Article
Anesthesiology
Ana B. Salinas-Abarca, Francisco G. Vazquez-Cuevas, Adriana Gonzalez-Gallardo, Guadalupe Martinez-Lorenzana, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: Sexual dimorphism plays a significant role in pain processing and response to analgesic drugs. Oxytocin showed a preference for preventing LPS-induced hypersensitivity in male rats compared to females, indicating a potential gender-specific analgesic effect. The results suggest that different strategies may be needed to treat pain in men and women, with oxytocin potentially being more effective for pain with an inflammatory component in men.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Neurosciences
Guadalupe Martinez-Lorenzana, Lourdes Palma-Tirado, Carmen Cifuentes-Diaz, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: Oxytocin and its receptor play a role in analgesia at the spinal dorsal horn, possibly through a presynaptic mechanism or mediated by GABA interneurons. Additionally, the expression of oxytocin receptor in glial tissue at the spinal dorsal horn requires further investigation in nociception assays.
Article
Pharmacology & Pharmacy
Gustavo Lopez-Cordoba, Guadalupe Martinez-Lorenzana, Jair Lozano-Cuenca, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
Summary: Spinal alpha(2)-adrenoceptors induce analgesia by inhibiting primary afferent fibers. The alpha(2A) subtype is involved in acute or tonic nociception, while the alpha(2C) subtype has an opposing effect under tonic nociceptive input.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Ana B. Salinas-Abarca, Guadalupe Martinez-Lorenzana, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
Summary: Activation of the oxytocin receptor (OTR) in the spinal cord can produce antinociception. It is suggested that central OTR activation enhances social interaction through an increase in endocannabinoids (eCB), but it's unclear if this also occurs at the spinal level, modulating pain transmission. This study aimed to investigate the role of the eCB system in spinal oxytocin-induced antinociception.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Abimael Gonzalez-Hernandez, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink, Carlos M. M. Villalon
Summary: 5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or neurotransmitter in various nervous system functions. Its actions are complex and depend on multiple factors, including the type of effector or receptor activated. This review summarizes and discusses the impact of 5-HT on blood pressure regulation and vascular-related diseases.