Article
Medicine, General & Internal
Yu Chen, Xin Ye, Han Wu, Xueling Yuan, Xiaofang Yu, Huanghui Wu, Xiaodan Wu, Yanqing Chen
Summary: This study retrospectively analyzed the influence of epidural labour analgesia (ELA) on delivery and maternal and neonatal outcomes in nulliparous women with gestational diabetes mellitus (GDM) using propensity score-matched analysis. The results showed that ELA was associated with a decreased rate of caesarean section and an increased occurrence of assisted vaginal delivery. ELA was also found to prolong the duration of labor stages, increase the occurrence of postpartum fever, shorten hospital stay, and improve neonatal outcomes such as birth weight and plasma glucose levels.
Article
Anesthesiology
Doo-Hwan Kim, Hyun-Jung Kwon, Bokyoung Jeon, Dokyeong Lee, Jin-Woo Shin, Seong-Soo Choi
Summary: The study showed that using the 60 degrees +/- 5 degrees CLO view in fluoroscopic-guided mid-thoracic epidural access can increase success rate and patient satisfaction, and reduce procedural time and patient discomfort.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shiori Yamazaki, Sachie Koike, Takashi Eguchi, Shunichiro Matsuoka, Tetsu Takeda, Kentaro Miura, Kazutoshi Hamanaka, Kimihiro Shimizu
Summary: This study investigated the necessity of thoracic epidural analgesia (TEA) during minimally invasive surgery (MIS) and the noninferiority of preemptive intercostal nerve block (ICNB) to TEA. The results showed that approximately one-third of patients undergoing MIS discontinued TEA early, and ICNB can be an alternative to TEA, providing equivalent pain relief.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Yongsoo Lee, Sunmin Kim, Jin-Woo Shin, Jeong-Gil Leem, Seong-Soo Choi
Summary: In this study, factors associated with successful responses after lumbar epidural intervention in patients with chronic lumbar neuropathic radicular pain were evaluated. Patients with a higher DN4 score had a lower proportion of successful responders, and the adjuvant use of hypertonic saline during epidural interventions was associated with success at 1 month.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Anesthesiology
Sojin Shin, Jong-Hyuk Lee, Hyun-Jung Kwon, Ingon Lee, Dongseok Kim, Hakmoo Cho, Doo-Hwan Kim, Sung-Moon Jeong
Summary: This study suggests that the prone position may be preferred for real-time ultrasound-guided thoracic epidural catheter placement (US-TECP), as it has better clinical usefulness, reducing needling time and the number of needle passes and skin punctures, and improving the first-pass success rate.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Medicine, General & Internal
Armin N. Flinspach, Florian J. Raimann, Richard Schalk, Lena Bepler, Miriam Ruesseler, Mairen H. Flinspach, Kai Zacharowski, Jasmina Sterz
Summary: This study analyzed videos on YouTube about epidural catheter placement and found that most of the videos were of poor quality and unsuitable for self-study due to serious errors and patient safety issues. The lack of quality control makes it difficult to find suitable videos for educational purposes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anesthesiology
Jatin Joshi, Michelle Roytman, Rohit Aiyer, Elizabeth Mauer, J. Levi Chazen
Summary: This study aimed to evaluate the prevalence of cervical ligamentum flavum midline gaps using MRI. The results showed that full gaps of the ligamentum flavum were commonly observed in the lower cervical spine, with the highest incidence at the C7-T1 level. Interventionists should consider these normal variants when planning interventions.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Veterinary Sciences
Hope Douglas, Monica Midon, Kavita Shroff, Dario Floriano, Bernd Driessen, Klaus Hopster
Summary: This study retrospectively analyzed the use of caudal epidural catheters for long-term analgesic administration in hospitalized equine patients. The results showed that caudal epidural catheters are widely used in horses and have a positive response in the majority of cases. However, there are some complications associated with their use. Approximately 52.1% of the studied horses survived to be discharged from the hospital.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Chemistry, Medicinal
Panu Piirainen, Hannu Kokki, Merja Kokki
Summary: Epidural administration of oxycodone has advantageous pharmacokinetics and higher efficacy compared to intravenous administration, making it a potential option for epidural analgesia.
Article
Anesthesiology
Laurel Walfish, Sultan Alobaikan, Zubin Lahijanian, Christine Saint-Martin, Maria DelPilar Cortes Nino, Pablo Mauricio Ingelmo
Summary: This case report describes a young patient with multilevel cerebrospinal fluid leaks and status migrainosus. After multiple catheter-guided blood patch procedures, the patient's symptoms resolved without further complications.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Lixuan Li, Pupu Li, Jing Guo, Yifei Wu, Qian Zeng, Nan Li, Xiaoting Huang, Yongshen He, Wen Ai, Wuping Sun, Tao Liu, Donglin Xiong, Lizu Xiao, Yanyan Sun, Qiming Zhou, Haixia Kuang, Zilong Wang, Changyu Jiang
Summary: This study found that the expression of oxytocin receptors (OXTR) is upregulated in chemotherapy-induced neuropathic pain (CINP), and activation of OXTR can alleviate CINP symptoms by inhibiting neural excitability.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Anesthesiology
Ji Hoon Sim, Han Park, Yujin Kim, Jin-Woo Shin, Jeong-Gil Leem, Hyun-Seok Cho, Seong-Soo Choi
Summary: This study compared the effectiveness of TF and parasagittal IL approaches for cervical ESI, finding that parasagittal IL ESI may be recommended over TF ESI in reducing cervical radicular pain.
Article
Clinical Neurology
Jiahui Li, Pengyun Xie, Xiaolei Liu, Daheng Li, Jing Tang
Summary: This case report highlights the importance of early identification and appropriate treatment of extradural venous angiomas following sudden paralysis after epidural analgesia. The patient experienced paraplegia due to hemorrhage from extradural venous angiomas, but successful decompression surgery was performed immediately. After 5 months, the patient showed improvement in urinary retention and recovery of muscle strength, but residual spasticity remained. It is essential to carefully assess the potential risks and benefits before administering epidural analgesia for undetermined pain to minimize complications.
FRONTIERS IN NEUROLOGY
(2023)
Article
Anesthesiology
Ji Yeong Kim, Jong Seok Lee, Ji Young Kim, Ji Won Baek, Hye Su Kim, Do-Hyeong Kim
Summary: This study aimed to compare the intravascular injection rates of the Quincke needle and the Tuohy needle during an ultrasound-guided caudal block. The results showed that the incidence of intravascular injection was 13.9% with the Quincke needle and 7.8% with the Tuohy needle, and there was no significant difference between the two.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Oncology
Ana Tejedor, Lana Bijelic, Mauricio Polanco, Elisenda Pujol
Summary: Intravenous lidocaine infusion may be a safe and effective analgesic approach in cytoreductive surgery (CRS) and is associated with a significant reduction of opioid use and postoperative nausea and vomiting (PONV) compared to opioid-containing thoracic epidural anesthesia (TEA).
Article
Pharmacology & Pharmacy
Antonio Espinosa De Los Monteros-zuniga, Guadalupe Martinez-Lorenzana, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Abimael Gonzalez-Hernandez, Miguel Condes-Lara, Enrique Garcia-Boll, Carlos M. Villalon
Summary: Neuropeptides play an important role in migraine pathophysiology, with molecules such as CGRP, PACAP, OT, and orexins showing potential as novel targets for treatment. However, targeting these neuropeptide systems may lead to both antimigraine effects and potential side effects due to their complex intracellular mechanisms. Pharmacokinetics issues may also limit the use of molecules targeting neuropeptidergic transmission.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Neurosciences
Mohammed Gamal-Eltrabily, Guadalupe Martinez-Lorenzana, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: Nociception modulation involves multiple cortical areas and mechanisms, including both descending modulation at spinal level and cortico-cortical or cortico-subcortical interactions. Understanding the involvement of these areas and the neurotransmitters/neuromodulators studied in each area is crucial for pain modulation.
Article
Biochemical Research Methods
Guadalupe Martinez-Lorenzana, Mohammed Gamal-Eltrabily, Irma Alejandra Tello-Garcia, Ataulfo Martinez-Torres, Marymar Becerra-Gonzalez, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: The study showcases the application of CLARITY technique in visualizing neuronal connections and innervations in the nervous system in a transparent manner. Results indicate the reliability of CLARITY when combined with other techniques, providing valuable insights into neuroanatomical structures.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Biochemistry & Molecular Biology
Antonio Espinosa De los Monteros-Zuniga, Guadalupe Martinez-Lorenzana, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
Summary: Behavioral and electrophysiological data demonstrate that oxytocin inhibits pain transmission at the spinal level by activating OTRs, which can mediate two distinct intracellular pathways - Gq (PLC/NOS/GC/K-ATP(+)) or Gi proteins, leading to differential effects on early and late nociceptive responses.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Abimael Gonzalez-Hernandez, Bruno A. Marichal-Cancino, Carlos M. Villalon
Summary: Monoclonal antibodies act as prophylactic antimigraine agents by targeting CGRP or its receptors, revolutionizing the treatment of this disorder. Despite their long half-lives and hepato-friendly properties, potential cardiovascular side effects and immunogenicity induced by autoantibodies against mAbs present safety concerns for long-term use.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Review
Clinical Neurology
Bruno A. Marichal-Cancino, Abimael Gonzalez-Hernandez, Raquel Guerrero-Alba, Roberto Medina-Santillan, Carlos M. Villalon
Summary: Migraine involves neurovascular, functional, and anatomical alterations, and there is no ideal preventive medication currently. However, some prophylactic medications may help decrease the frequency of migraine days. The mechanisms of action involved in antimigraine prophylaxis remain elusive.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2021)
Article
Anesthesiology
Ana B. Salinas-Abarca, Francisco G. Vazquez-Cuevas, Adriana Gonzalez-Gallardo, Guadalupe Martinez-Lorenzana, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: Sexual dimorphism plays a significant role in pain processing and response to analgesic drugs. Oxytocin showed a preference for preventing LPS-induced hypersensitivity in male rats compared to females, indicating a potential gender-specific analgesic effect. The results suggest that different strategies may be needed to treat pain in men and women, with oxytocin potentially being more effective for pain with an inflammatory component in men.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Neurosciences
Guadalupe Martinez-Lorenzana, Lourdes Palma-Tirado, Carmen Cifuentes-Diaz, Abimael Gonzalez-Hernandez, Miguel Condes-Lara
Summary: Oxytocin and its receptor play a role in analgesia at the spinal dorsal horn, possibly through a presynaptic mechanism or mediated by GABA interneurons. Additionally, the expression of oxytocin receptor in glial tissue at the spinal dorsal horn requires further investigation in nociception assays.
Article
Pharmacology & Pharmacy
Gustavo Lopez-Cordoba, Guadalupe Martinez-Lorenzana, Jair Lozano-Cuenca, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
Summary: Spinal alpha(2)-adrenoceptors induce analgesia by inhibiting primary afferent fibers. The alpha(2A) subtype is involved in acute or tonic nociception, while the alpha(2C) subtype has an opposing effect under tonic nociceptive input.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Ana B. Salinas-Abarca, Guadalupe Martinez-Lorenzana, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
Summary: Activation of the oxytocin receptor (OTR) in the spinal cord can produce antinociception. It is suggested that central OTR activation enhances social interaction through an increase in endocannabinoids (eCB), but it's unclear if this also occurs at the spinal level, modulating pain transmission. This study aimed to investigate the role of the eCB system in spinal oxytocin-induced antinociception.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Abimael Gonzalez-Hernandez, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink, Carlos M. M. Villalon
Summary: 5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or neurotransmitter in various nervous system functions. Its actions are complex and depend on multiple factors, including the type of effector or receptor activated. This review summarizes and discusses the impact of 5-HT on blood pressure regulation and vascular-related diseases.
Review
Neurosciences
Abimael Gonzalez-Hernandez, Bruno A. Marichal-Cancino, Enrique Garcia-Boll, Carlos M. Villalon
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2020)
